MRI-clinical correlations: more than inflammation alone-what can MRI contribute to improve the understanding of pathological processes in MS?
Abstract
Magnetic resonance imaging (MRI) is a sensitive technique in the detection and follow-up of multiple sclerosis (MS) lesions. However, the pathologic basis of these changes is poorly understood. It is becoming increasingly apparent that routine MRI techniques do not represent specific histopathologic changes but reflect a variety of pathological changes in tissue. This review will outline the findings in MRI-pathology correlation in MS to date, and the current understanding of the evolution of pathologic changes in the MS lesion and non-lesional white matter as reflected by MRI. Possible future contributions of MRI to unveiling the dynamic pathology of MS will also be discussed.
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Aside from a relationship between Gd enhancement and inflammation, conventional MRI techniques do not distinguish other histopathological substrates of MS.
“Aside from a relationship between Gd enhancement and inflammation (Hawkins et al., 1990; Katz et al., 1993), however, such conventional MRI (cMRI) techniques do not distinguish other histopathological substrates of MS (Moore, 2003).”
From Diffusion tensor imaging of post mortem multiple sclerosis brain (2007) · cites this paper as Moore, 2003
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Alper, F., Gundogdu, C., Varoglu, A., Kantarci, M., Bulucu, Z., Malkoç, I., & Unal, B. (2006) · The Neuroradiology Journal · doi:10.1177/197140090601900302
- Authors
- Wayne Moore, G. R.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 206
- Issue
- 2
- Pages
- 175-179
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2029887685
- Cited by
- 35
- References
- 0
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society of Canada
- University of British Columbia
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- multiple sclerosis, MRI-pathology correlation, demyelination, white matter lesions, lesion evolution, inflammation, histopathology, neurodegeneration
- MeSH terms
- Brain, Clinical Trials as Topic, Humans, Inflammation, Magnetic Resonance Imaging, Multiple Sclerosis, Predictive Value of Tests, Disease Progression
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