Endothelial stunning and myocyte recovery after reperfusion of jeopardized muscle: a role of L-arginine blood cardioplegia
Open accessAbstract
Ischemia and reperfusion may damage myocytes and endothelium in jeopardized hearts. This study tested whether (1) endothelial dysfunction (reduced nitric oxide release) exists despite good contractile performance and (2) supplementation of blood cardioplegic solution with nitric oxide precursor L-arginine augments nitric oxide and restores endothelial function. Among 30 Yorkshire-Duroc pigs, 6 received standard glutamate/aspartate blood cardioplegic solution without global ischemia. Twenty-four underwent 20 minutes of 37 degrees C global ischemia. Six received normal blood reperfusion. In 18, the aortic clamp remained in place 30 more minutes and all received 3 infusions of blood cardioplegic solution. In 6, the blood cardioplegic solution was unaltered; in 6, the blood cardioplegic solution contained L-arginine (a nitric oxide precursor) at 2 mmol/L; in 6, the blood cardioplegic solution contained the nitric oxide synthase inhibitor L-nitro arginine methyl ester (L-NAME) at 1 mmol/L. Complete contractile and endothelial recovery occurred without ischemia. In jeopardized hearts, complete systolic recovery followed infusion of blood cardioplegic solution and of blood cardioplegic solution plus L-arginine. Conversely, contractility recovered approximately 40% after infusion of normal blood and blood cardioplegic solution plus L-NAME. Postischemic nitric oxide production fell 50% in the groups that received blood cardioplegic solution and blood cardioplegic solution plus L-NAME but was increased in the group that received blood cardioplegic solution L-arginine. In vivo endothelium-dependent vasodilator responses to acetylcholine recovered 75% +/- 5% of baseline in the blood cardioplegic solution plus L-arginine group, but less than 20% of baseline in other jeopardized hearts. Endothelium-independent smooth muscle responses to sodium nitroprusside were relatively unaltered. Myeloperoxidase activity (neutrophil accumulation) was similar in the blood cardioplegic solution (without ischemia) and blood cardioplegic solution plus L-arginine groups (0.01 +/- 0.002 vs 0.013 +/- 0.003 microgram/gm tissue). Myeloperoxidase activity was raised substantially to 0.033 +/- 0.002 microgram/gm after exposure to normal blood and to 0.025 +/- 0.003 microgram/gm after infusion of blood cardioplegic solution and was highest at 0.053 +/- 0.01 microgram/gm with exposure to blood cardioplegic solution plus L-NAME in jeopardized hearts. The discrepancy between contractile recovery and endothelial dysfunction in jeopardized muscle can be reversed by adding L-arginine to blood cardioplegic solution.
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Endothelium-derived NO plays an important role in vascular homeostasis and cardiac function.
“It is well known that endothelium-derived nitric oxide (NO) plays an important role in vascular homeostasis and cardiac function based on seminal studies leading to the Nobel Prize in Physiology or Medicine in 1998 [9, 10].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [10]
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Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works
Role of endothelium in responses of vascular smooth muscle.
Furchgott, R. F. (1983) · Circulation Research · doi:10.1161/01.res.53.5.557 · Cited by 1,961 · see citing works
Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348 · see citing works
L, X., Weyrich, A. S., Lefer, D. J., & Lefer, A. M. (1993) · Circulation Research · doi:10.1161/01.res.72.2.403 · Cited by 491 · see citing works
Rubanyi, G. M., Ho, E. H., Cantor, E. H., Lumma, W. C., & Botelho, L. H. P. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92093-y · Cited by 360 · see citing works
Endothelium‐derived relaxing factor inhibitsin vitroplatelet aggregation
Furlong, B., Henderson, A. H., LEWIS, M. J., & Smith, J. A. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11221.x · Cited by 352 · see citing works
The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.
Weyrich, A. S., Ma, X. L., & Lefer, A. M. (1992) · Circulation · doi:10.1161/01.cir.86.1.279 · Cited by 320 · see citing works
Safety of prolonged aortic clamping with blood cardioplegia
Rosenkranz, E. R., Okamoto, F., Buckberg, G. D., Robertson, J. M., Vinten‐Johansen, J., & Bugyi, H. I. (1986) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)36059-3 · Cited by 225 · see citing works
Self-citationTsao, P. S., & Lefer, A. M. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.6.h1660 · Cited by 200 · see citing works
Kono, A., Maughan, W. L., Sunagawa, K., Hamilton, K. K., SAGAWA, K., & Weisfeldt, M. L. (1984) · Circulation · doi:10.1161/01.cir.70.6.1057 · Cited by 191 · see citing works
Bush, P. A., Gonzalez, N. E., Griscavage, J. M., & Ignarro, L. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91720-b · Cited by 179 · see citing works
Self-citationBogle, R., Coade, S. B., Moncada, S., Pearson, J. D., & Mann, G. E. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81154-4 · Cited by 167 · see citing works
Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart
Patel, V. C., Yellon, D. M., Singh, K. J., Neild, G. H., & Woolfson, R. G. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1809 · Cited by 158 · see citing works
STUDIES OF CONTROLLED REPERFUSION AFTER ISCHEMIA
Allen, B. S., Okamoto, F., Buckberg, G. D., Bugyi, H. I., Young, H., Leaf, J. D., Beyersdorf, F., Sjöstrand, F. S., & Maloney, J. V. (1986) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)36513-4 · Cited by 153 · see citing works
Self-citationDepletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation
Gold, M. E., Bush, M. A., & Ignarro, L. J. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91518-0 · Cited by 125 · see citing works
Self-citationBoltwood, C. M., Appleyard, R. F., & Glantz, S. A. (1989) · Circulation · doi:10.1161/01.cir.80.5.1360 · Cited by 112 · see citing works
Sato, H., Zhao, Z.-Q., McGee, D. S., Williams, M. W., Hammon, J. W., & Vinten‐Johansen, J. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70226-1 · Cited by 105 · see citing works
Self-citationEndogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit
Williams, M. W., Taft, C. S., Ramnauth, S., Zhao, Z., & Vinten-Johansen, J. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00011-9 · Cited by 80 · see citing works
Self-citationCoronary artery endothelial function after myocardial ischemia and reperfusion
Seccombe, J. F., & Schaff, H. V. (1995) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00371-q · Cited by 60 · see citing works
Hiramatsu, T., Forbess, J. M., Miura, T., & Mayer, J. E. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70423-x · Cited by 51 · see citing works
Kawata, H., Sawatari, K., & Mayer, J. E. (1992) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34915-3 · Cited by 51 · see citing works
Juneau, C. F., Ito, B. R., del Balzo, U., & Engler, R. L. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.5.720 · Cited by 47 · see citing works
Sawatari, K., Kadoba, K., Ka, B., Ja, D., & Mayer, J. E. (1991) · PubMed · Cited by 44 · see citing works
Sawatari, K., Kadoba, K., Bergner, K. A., & Mayer, J. E. (1991) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)36646-2 · Cited by 44 · see citing works
Nakanishi, K., Zhao, Z., Vinten‐Johansen, J., Hudspeth, D. A., McGee, D. S., & Hammon, J. W. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70198-2 · Cited by 42 · see citing works
Self-citationL-Arginine inhibits neutrophil adherence and coronary artery dysfunction
Sato, H., Zhao, Z., & Vinten‐Johansen, J. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00171-9 · Cited by 42 · see citing works
Self-citationl ‐Arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells
Schmidt, H. H. H. W., Baeblich, S. E., Zernikow, B. C., Klein, M. M., & Böhme, E. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12104.x · Cited by 32 · see citing works
Coronary endothelial injury by cold crystalloid cardioplegic solution in neonatal lambs.
Aoki, M., Kawata, H., & Mayer, J. E. (1992) · PubMed · Cited by 18 · see citing works
Hiramatsu, T., Forbess, J. M., Miura, T., Nomura, F., & Mayer, J. E. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(05)80023-6 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Furlong B, Henderson AH, Lewis MJ, Smith JA. Endotheli- um-delivered relaxing factor inhibits in vitro platelet aggre- gation. Br J Pharmacol 1987;90:687-92.
- McCall T, White B JR, Boughton-Smith NK, Moncada S. Inhibition of FMLP-induced aggregation of rabbit neutro- phils by nitric oxide [abstract]. Br J Pharmacol 1988;95:517P.
Cited by
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Lerman, A., & Zeiher, A. M. (2005) · Circulation · doi:10.1161/01.cir.0000153339.27064.14 · Cited by 1,096 · see citing works
Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 597 · see citing works
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Szabo, G. B., Bährle, S., Stumpf, N., Sonnenberg, K., Szabó, É., Pacher, P., Csont, T., Schulz, R., Dengler, T. J., Liaudet, L., et al. (2002) · Circulation Research · doi:10.1161/hh0102.102657 · Cited by 161 · see citing works
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Nicolini, F. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00475-5 · Cited by 66 · see citing works
Al‐Ruzzeh, S., Athanasiou, T., George, S., Glenville, B., DeSouza, A., Pepper, J., & Amrani, M. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(03)00348-5 · Cited by 43 · see citing works
Burgdorf, C. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00309-6 · Cited by 41 · see citing works
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Szabo, G. B., Bährle, S., Bátkai, S., Stumpf, N., Dengler, T. J., Zimmermann, R., Vahl, C. F., & Hagl, S. (1998) · World Journal of Surgery · doi:10.1007/s002689900471 · Cited by 38 · see citing works
Iráculis, E., Cequier, A. R., Sabaté, M., Mauri, J., Fernández‐Nofrerías, E., del Blanco, B. G., Jara, F., & Esplugas, E. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01953-8 · Cited by 35 · see citing works
Podesser, B. K., Schirnhofer, J., Bernecker, O. Y., Kröner, A. H., Franz, M. B., Semsroth, S., Fellner, B., Neumüller, J., Hallström, S., & Wolner, E. (2002) · Circulation · doi:10.1161/01.cir.0000032903.33237.40 · Cited by 35 · see citing works
Carrier, M., Pellerin, M., Perrault, L. P., Bouchard, D., Pagé, P., Searle, N. R., & Lavoie, J. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(01)03414-2 · Cited by 34 · see citing works
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Beyersdorf, F. (2004) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2003.09.009 · Cited by 19 · see citing works
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Andrási, T. B., Soós, P., Bakos, G., Stumpf, N., Blázovics, A., Hagl, S., & Szabo, G. B. (2003) · Surgery · doi:10.1067/msy.2003.208 · Cited by 18 · see citing works
Kronon, M. T., Allen, B. S., Bolling, K. S., Rahman, S., Wang, T., Maniar, H. S., Prasad, S. M., & Ilbawi, M. N. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)01713-6 · Cited by 17 · see citing works
Castellà, M., Buckberg, G. D., Tan, Z., & Ignarro, L. J. (2002) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2002.125485 · Cited by 17 · see citing works
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Velianou, J. L., Suwaidi, J. M. S. A., & Lerman, A. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.11.1785 · Cited by 16 · see citing works
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Temiztürk, Z., AZBOY, D., & Uysal, A. (2021) · The Heart Surgery Forum · doi:10.1532/hsf.3265 · Cited by 5 · see citing works
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Baker, C., Kumar, S., & Rimoldi, O. E. (2003) · Heart Failure Reviews · doi:10.1023/a:1023088601481 · Cited by 4 · see citing works
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Self-citationJakubowski, A., & Łomnicka, M. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3287 · Cited by 1 · see citing works
Role of Nitric Oxide in Myocardial Ischemia-Reperfusion Injury
Vinten‐Johansen, J., & Buckberg, G. D. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50042-3 · Cited by 1 · see citing works
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Podesser, B. K., Trescher, K., & Dietl, W. (2010) · Springer eBooks · doi:10.1007/978-3-211-85548-5_7 · Cited by 1 · see citing works
Enrichissement métabolique en chirurgie cardiaque
Girard, C., Moussiegt, N., Gilson, L., & Rapenne, T. (1998) · IRBM News · doi:10.1016/s0222-0776(99)80022-4
Preservation solution in heart transplantation
Menasché, P. (1998) · Springer eBooks · doi:10.1007/978-94-011-4984-6_25
Ischemia and reperfusion injury of the myocardium.
Bidstrup, B. P., Endara, S. A., & Boldery, J. (2001) · PubMed
- Authors
- Mizuno, A., Baretti, R., Buckberg, G. D., Young, H. H., Vinten-Johansen, J., Ma, X.-L., & Ignarro, L. J.
- Affiliations
- University of California, Los Angeles (US)
- Atrium Health Wake Forest Baptist (US)
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 113
- Issue
- 2
- Pages
- 379-389
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2018124850
- Cited by
- 43
- References
- 30
- Citations by year
- 2021: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- myocardial stunning, L-arginine, blood cardioplegia, nitric oxide, endothelial dysfunction, myocardial ischemia-reperfusion injury, L-NAME, nitric oxide synthase inhibition, endothelium-dependent vasodilation, acetylcholine, neutrophil accumulation, myeloperoxidase
- MeSH terms
- Animals, Cardioplegic Solutions, Disease Models, Animal, Endothelium, Vascular, Enzyme Inhibitors, Peroxidase, Myocardium, Swine, Swine, Miniature, Vasodilation, Myocardial Stunning, NG-Nitroarginine Methyl Ester
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