Endothelial Function: Cardiac Events
Abstract
A growing body of evidence suggests that endothelial dysfunction is associated with cardiovascular events.Endothelial dysfunction can be regarded as a syndrome that exhibits systemic manifestations associated with significant morbidity and mortality.The concept of endothelial dysfunction should be extended beyond the conduit vessels into the vascular wall and even to the bone marrow and the progenitor endothelial cells.The present review is focused on the potential underlying mechanism by which endothelial dysfunction may contribute to cardiovascular events.The assessment of endothelial function may emerge as an integral adjuvant test for evaluation of the vulnerable patients at risk for future cardiovascular events.
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Impaired coronary endothelial function and impaired myocardial blood flow response assessed by PET are independent predictors of unfavorable cardiovascular outcome.
“Nevertheless, because impairment of coronary endothelial function (32) and specifically impaired MBF response as assessed by PET (33) have been shown to be independent predictors of unfavorable cardiovascular outcome, our results may at least raise questions about safety in patients with impaired MFR, such as CAD patients.”
From Caffeine decreases exercise-induced myocardial flow reserve (2006) · cites this paper as [32]
Endothelial dysfunction, defined as a reduced vasodilator response to acetylcholine, is an early prognostic indicator for the onset of cardiovascular disease.
“endothelial dysfunction, which can be defined as a reduced vasodilator response to acetylcholine, is an early prognostic indicator for the onset of cardiovascular disease (168–171).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [171]
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- Authors
- Lerman, A., & Zeiher, A. M.
- Affiliations
- Goethe University Frankfurt (DE)
- Venue
- Circulation
- Published
- 2005-01-25
- Volume
- 111
- Issue
- 3
- Pages
- 363-368
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2113842550
- Cited by
- 1,096
- References
- 67
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 33 · 2023: 36 · 2022: 41 · 2021: 53 · 2020: 58 · 2019: 52 · 2018: 50 · 2017: 40 · 2016: 52 · 2015: 53 · 2014: 83 · 2013: 79 · 2012: 70
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Mayo Foundation for Medical Education and Research
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL-69840, K24HL069840, HL-63911, R01HL063911)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- endothelial dysfunction, endothelial function, cardiovascular events, cardiovascular risk, vascular wall, bone marrow, endothelial function assessment
- MeSH terms
- Animals, Bone Marrow Cells, Coronary Thrombosis, Endothelium, Vascular, Heart Diseases, Heart Failure, Humans, Stem Cells, Death, Sudden, Cardiac, Risk Assessment, Endothelial Cells
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