The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
YOHIMBINE FOR ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS
Abstract
PURPOSE: Erectile dysfunction is a common problem, particularly in diabetics. It is associated with a considerable burden of suffering. No generally accepted drug treatment exists. We systematically reviewed and meta-analyzed all randomized, placebo controlled trials of yohimbine monotherapy for erectile dysfunction to determine its therapeutic efficacy. Our secondary aim was to evaluate the safety of yohimbine. MATERIALS AND METHODS: We used computerized literature searches and standardized data extraction to rate methodological quality in a meta-analysis using computer statistical software. RESULTS: Seven trials fit the predefined inclusion criteria. Overall methodological quality of these studies was satisfactory. The meta-analysis demonstrated that yohimbine is superior to placebo in the treatment of erectile dysfunction (odds ratio 3.85, 95% confidence interval 6.67 to 2.22). Serious adverse reactions were infrequent and reversible. CONCLUSIONS: The benefit of yohimbine medication for erectile dysfunction seems to outweigh its risks. Therefore, yohimbine is believed to be a reasonable therapeutic option for erectile dysfunction that should be considered as initial pharmacological intervention.
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Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
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Lue, T. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422407 · Cited by 1,252
Herbal Medicine. Expanded Commission E Monographs
Pittler, M. (2000) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2000.tb02556.x · Cited by 344
Self-citationAntidepressants and sexual dysfunction
Werneke, U., Northey, S., & Bhugra, D. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00890.x · Cited by 176
Allen, M. S., & Walter, E. E. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.01.314 · Cited by 116
Rhim, H. C., Kim, M. S., Park, Y.-J., Choi, W. S., Park, H. K., Kim, H. G., Kim, A., & Paick, S. H. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.12.002 · Cited by 57
Metadata
- Authors
- Ernst, E., & Pittler, M. H.
- Venue
- Journal of Urology
- Published
- 1998-02
- Volume
- 159
- Issue
- 2
- Pages
- 433-436
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W1980214648
- Cited by
- 297
- References
- 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: YOHIMBINE FOR ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS. https://app.cochat.ai/papers/10.1016/s0022-5347(01)63942-9
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- Ernst, E., & Pittler, M. H. (1998). YOHIMBINE FOR ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS. Journal of Urology. https://doi.org/10.1016/s0022-5347(01)63942-9
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