Antidepressants and sexual dysfunction

Werneke, U.; Northey, S.; Bhugra, D.

doi:10.1111/j.1600-0447.2006.00890.x

Cited by 176Sexual function and dysfunction studiesTreatment of Major DepressionSexuality, Behavior, and Technology

Antidepressants and sexual dysfunction

Werneke, U., Northey, S., Bhugra, D.·2006·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2006.00890.x

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Abstract

Objective: Many patients with depression suffer from sexual dysfunction and sexual dysfunction is a recognized side‐effect of antidepressants. The aim of this review was to examine the prevalence of psychosexual dysfunction associated with antidepressants, and to review treatment options which are specific to the affected component of sexual functioning and antidepressants. Method: Comprehensive literature review using Medline and Cochrane databases. Results: Up to 70% of patients with depression may have sexual dysfunction. Tricyclic antidepressants, selective‐serotonin reuptake inhibitors and venlafaxine are most and the non‐serotonergic antidepressants and duloxetine least likely to produce sexual dysfunction. Pharmacological treatment options include antidepressants less likely associated or ‘antidotes’ to reverse sexual dysfunction. Conclusion: Sexual dysfunction may be a preventable or treatable side‐effect of antidepressants. Patients need routinely to be asked about sexual function to identify problems early. If sexual dysfunction is ignored it may maintain the depression, compromise treatment outcome and lead to non‐compliance.

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Authors: Werneke, U., Northey, S., & Bhugra, D.
Affiliations: Queen Mary University of London (GB)
University of Surrey (GB)
King's College London (GB)
Corresponding author: Werneke, U.
ORCID: Werneke, U.
Bhugra, D.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2006-08-22
Volume: 114
Issue: 6
Pages: 384-397
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.2006.00890.x
OpenAlex: W2142808474
Cited by: 176
References: 142
Citations by year: 2026: 5 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 17 · 2012: 12
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords: antidepressant-induced sexual dysfunction, depression, tricyclic antidepressants, selective serotonin reuptake inhibitors, venlafaxine, duloxetine, antidepressant side effects, medication adherence
MeSH terms: Antidepressive Agents, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Male, Risk Factors, Sexual Dysfunction, Physiological, Evidence-Based Medicine

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