The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nitric Oxide in the Penis: Physiology and Pathology
Abstract
PURPOSE: The significance of nitric oxide in the physiology of the penis was evaluated, including its role in pathophysiological mechanisms and pathological consequences involving this organ. MATERIALS AND METHODS: Animal and human studies pertaining to nitric oxide in the penis were reviewed and analyzed in the context of current descriptions of the molecular biology and physiological effects of this chemical. RESULTS: Potential sources of nitric oxide in the penis include neurons, sinusoidal endothelium and corporeal smooth muscle cells. Nitric oxide is perceived to exert a host of functional roles by binding with specific molecular targets. Its synthesis and action in the penis are influenced by many different regulatory factors. CONCLUSIONS: Nitric oxide exerts a significant role in the physiology of the penis, operating chiefly as the principal mediator of erectile function. Alterations in the biology of nitric oxide likely account for various forms of erectile dysfunction. The diverse physiological roles of nitric oxide suggest that it may also directly contribute to or cause pathological consequences involving the penis.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Nitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752
Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006
(1991) · doi:10.1172/jci115266 · Cited by 429
Cited by
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection
Hurt, K. J., Musicki, B., Palese, M. A., Crone, J. K., Becker, R. E., Moriarity, J. L., Snyder, S. H., & Burnett, A. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052712499 · Cited by 379
Self-citationEffects of sildenafil citrate on human hemodynamics
Jackson, G., Benjamin, N., Jackson, N., & Allen, M. J. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00043-0 · Cited by 368
Webb, D. J., Freestone, S., Allen, M. J., & Muirhead, G. J. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00044-2 · Cited by 329
THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION
MELMAN, A., & GINGELL, J. C. (1999) · Journal of Urology · doi:10.1016/s0022-5347(01)62045-7 · Cited by 308
Kandeel, F. R., Koussa, V. K. T., & Swerdloff, R. S. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0430 · Cited by 270
Metadata
- Authors
- Burnett, A. L.
- Venue
- Journal of Urology
- Published
- 1997-01
- Volume
- 157
- Issue
- 1
- Pages
- 320-324
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W1971843632
- Cited by
- 350
- References
- 5
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- closed
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