The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
AUGMENTED STRETCH ACTIVATED ADENOSINE TRIPHOSPHATE RELEASE FROM BLADDER UROEPITHELIAL CELLS IN PATIENTS WITH INTERSTITIAL CYSTITIS
Abstract
PURPOSE: Extracellular adenosine triphosphate (ATP) has been shown to mediate inflammation and nociception and, therefore, it may have a role in symptoms associated with interstitial cystitis. We theorized that the bladder uroepithelium releases ATP in response to stretch and, furthermore, this process is augmented in interstitial cystitis. MATERIALS AND METHODS: We quantitated ATP using the luciferin-luciferase assay. Urinary ATP levels were compared in 35 patients with interstitial cystitis and in 33 normal controls after pH correction. Cultured interstitial cystitis and normal urothelial cells from the bladder biopsies of 5 patients each were stretched with the Flexcell 2000 machine (Flexcell International Corp., McKeesport, Pennsylvania) and supernatant ATP concentrations were measured. RESULTS: Mean urinary ATP plus or minus standard error of mean was significantly higher in patients with interstitial cystitis than in controls (L value 985 +/- 161 versus 377 +/- 27, p = 0.0007). Supernatant ATP released by stretched interstitial cystitis cells was stretch intensity dependent when comparing 0%, 10% and 20% elongation, and was also significantly higher in stretched interstitial cystitis than in stretched normal cells. CONCLUSIONS: Adenosine triphosphate was significantly elevated in the urine of individuals with interstitial cystitis and the stretch activated release of ATP was augmented in interstitial cystitis urothelium. Increased extracellular ATP may have a role in mechanosensory transduction and to our knowledge it represents a novel hypothesis.
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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
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P2X3Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP
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Distinct ATP receptors on pain-sensing and stretch-sensing neurons
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THE ROLE OF URINARY POTASSIUM IN THE PATHOGENESIS AND DIAGNOSIS OF INTERSTITIAL CYSTITIS
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CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli
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Evidence for Purinergic Neurotransmission in Human Urinary Bladder Affected by Interstitial Cystitis
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CYSTOSCOPIC FINDINGS CONSISTENT WITH INTERSTITIAL CYSTITIS IN NORMAL WOMEN UNDERGOING TUBAL LIGATION
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Cited by
Mechanisms of Disease: involvement of the urothelium in bladder dysfunction
Birder, L. A., & de Groat, W. C. (2007) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0672 · Cited by 364
Development, plasticity and modulation of visceral afferents
Christianson, J. A., Bielefeldt, K., Altier, C., Cenac, N., Davis, B. M., Gebhart, G. F., High, K. W., Kollarik, M., Randich, A., Undem, B., et al. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.004 · Cited by 80
Soukup, O., Winder, M., Killi, U. K., Wsol, V., Jun, D., Kuca, K., & Tobin, G. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160607212615 · Cited by 34
Metadata
- Authors
- SUN, Y., KEAY, S., De DEYNE, P. G., & CHAI, T. C.
- Venue
- Journal of Urology
- Published
- 2001-11
- Volume
- 166
- Issue
- 5
- Pages
- 1951-1956
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2084464265
- Cited by
- 255
- References
- 16
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- SUN, Y., KEAY, S., De DEYNE, P. G., & CHAI, T. C. (2001). AUGMENTED STRETCH ACTIVATED ADENOSINE TRIPHOSPHATE RELEASE FROM BLADDER UROEPITHELIAL CELLS IN PATIENTS WITH INTERSTITIAL CYSTITIS. Journal of Urology. https://doi.org/10.1016/s0022-5347(05)65726-6
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