The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli
Abstract
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated ATP efflux has been proposed as an autocrine mechanism for regulating chloride secretion through other types of chloride channels. Although we found in previous studies that wild-type CFTR channels bathed with high-ATP solutions do not conduct ATP at rates that can be measured with the patch-clamp technique, those experiments would not have detected very small or electroneutral ATP fluxes through CFTR or ATP efflux through other pathways that might be regulated by CFTR. To examine these possibilities, we have now used a sensitive luciferase luminometric assay to measure ATP efflux from epithelial and nonepithelial cell lines. Adenosine 3',5'-cyclic monophosphate (cAMP) stimulation did not raise external ATP concentration above the background noise in any of the cell lines tested [T84, Calu-3, 9HTEo- and sigma CFTE29o- (colonic and airway human epithelial cells, respectively), NIH/3T3 fibroblasts, and Chinese hamster ovary cells], and variations in ATP release were not correlated with CFTR expression. The rate of ATP release was unaffected by cAMP but was exquisitely sensitive to mechanical perturbations in both CFTR expressing and nonexpressing cells. Mechanically induced, CFTR-independent ATP release may be a physiologically relevant mechanism of epithelial regulation, which has not previously been fully appreciated.
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Cites
CFTR as a cAMP-Dependent Regulator of Sodium Channels
Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., & Boucher, R. C. (1995) · Science · doi:10.1126/science.7543698 · Cited by 1,088
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene
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Self-citationCalcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells
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Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.
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Self-citationIncorporation of cytoplasmic vesicles into apical membrane of mammalian urinary bladder epithelium
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Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP
Reddy, M. M., Quinton, P. M., Haws, C., Wine, J. J., Grygorczyk, R., Tabcharani, J. A., Hanrahan, J. W., Gunderson, K. L., & Kopito, R. R. (1996) · Science · doi:10.1126/science.271.5257.1876 · Cited by 188
Self-citationRegulation of Ion Channels by ABC Transporters That Secrete ATP
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Cited by
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Luckprom, P., Wongkhantee, S., Yongchaitrakul, T., & Pavasant, P. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2009.01256.x · Cited by 29
Metadata
- Authors
- Grygorczyk, R., & Hanrahan, J. W.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1997-03-01
- Volume
- 272
- Issue
- 3
- Pages
- C1058-C1066
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2418980125
- Cited by
- 258
- References
- 13
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grygorczyk, R., & Hanrahan, J. W. (1997). CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1997.272.3.c1058
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
