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Cited by 417

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

An Analysis of the Natural History of Peyronie’s Disease

Mulhall, John P., Schiff, Jonathan, Guhring, Patricia·2006·Journal of Urology

Abstract

PURPOSE: Little information exists on the natural history of PD. We defined the course of PD in a group of men with this condition who received no treatment. MATERIALS AND METHODS: The study population comprised patients with PD who presented within 6 months of disease onset, had no medical treatment and were followed until at least 12 months after disease onset. At baseline and followup penile abnormality was determined following intracavernous injection and by measurement at maximum penile rigidity. RESULTS: A total of 246 patients met inclusion criteria. At presentation mean age +/- SD was 52 +/- 22 years and the duration of PD was 3.5 +/- 1.5 months. At baseline in men with documented curvature 72% had dorsal, 17% had ventral and 11% had lateral curvature. Mean curvature at baseline was 42 +/- 22 degrees. Mean stretched flaccid penile length was 12.2 cm. The mean duration of PD at the followup assessment was 18 +/- 7 months. At followup stretched flaccid length had decreased to 11.4 cm (p = 0.035). Of the patients 32% complained of some degree of erectile dysfunction at baseline. All patients who reported penile pain had improvement and 89% reported complete resolution at followup. Of men with curvature 12% had improved, 40% remained stable and 48% had worsened at followup. In those in whom curvature improved the mean change was 15 degrees, while in those in whom curvature worsened the mean change was 22 degrees. CONCLUSIONS: To our knowledge this is the largest study to explore the natural history of PD. A minority of men experienced improvement in penile abnormality, while penile length decreased during the 1-year followup. This information will permit clinicians to provide patients with realistic expectations at presentation for the evaluation of PD.

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Research works printed but not linked: 1

  1. de la Peyronie, 1743, Sur quelques obstacles qui s’opposent a l’ejaculation naturelle de la semence, Mem Acad Chir, 1, 318

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Metadata

Authors
Mulhall, J. P., Schiff, J., & Guhring, P.
Venue
Journal of Urology
Published
2006-06
Volume
175
Issue
6
Pages
2115-2118
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
OpenAlex
W2124991789
Cited by
417
References
15
FWCI
6.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: An Analysis of the Natural History of Peyronie’s Disease. https://app.cochat.ai/papers/10.1016/s0022-5347(06)00270-9
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Mulhall, J. P., Schiff, J., & Guhring, P. (2006). An Analysis of the Natural History of Peyronie’s Disease. Journal of Urology. https://doi.org/10.1016/s0022-5347(06)00270-9

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