The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
An Analysis of the Natural History of Peyronie’s Disease
Abstract
PURPOSE: Little information exists on the natural history of PD. We defined the course of PD in a group of men with this condition who received no treatment. MATERIALS AND METHODS: The study population comprised patients with PD who presented within 6 months of disease onset, had no medical treatment and were followed until at least 12 months after disease onset. At baseline and followup penile abnormality was determined following intracavernous injection and by measurement at maximum penile rigidity. RESULTS: A total of 246 patients met inclusion criteria. At presentation mean age +/- SD was 52 +/- 22 years and the duration of PD was 3.5 +/- 1.5 months. At baseline in men with documented curvature 72% had dorsal, 17% had ventral and 11% had lateral curvature. Mean curvature at baseline was 42 +/- 22 degrees. Mean stretched flaccid penile length was 12.2 cm. The mean duration of PD at the followup assessment was 18 +/- 7 months. At followup stretched flaccid length had decreased to 11.4 cm (p = 0.035). Of the patients 32% complained of some degree of erectile dysfunction at baseline. All patients who reported penile pain had improvement and 89% reported complete resolution at followup. Of men with curvature 12% had improved, 40% remained stable and 48% had worsened at followup. In those in whom curvature improved the mean change was 15 degrees, while in those in whom curvature worsened the mean change was 22 degrees. CONCLUSIONS: To our knowledge this is the largest study to explore the natural history of PD. A minority of men experienced improvement in penile abnormality, while penile length decreased during the 1-year followup. This information will permit clinicians to provide patients with realistic expectations at presentation for the evaluation of PD.
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The Natural History of Peyronie’s Disease
Gelbard, M. K., Dorey, F., & James, K. (1990) · Journal of Urology · doi:10.1016/s0022-5347(17)39746-x · Cited by 525
The prevalence of Peyronie's disease: results of a large survey
Schwarzer, U., Sommer, F., Klotz, T., Braun, M., Reifenrath, B., & Engelmann, U. (2001) · BJU International · doi:10.1046/j.1464-4096.2001.02436.x · Cited by 440
MULHALL, J. P., CREECH, S. D., BOORJIAN, S. A., GHALY, S., KIM, E. D., MOTY, A., DAVIS, R., & HELLSTROM, W. (2004) · Journal of Urology · doi:10.1097/01.ju.0000127744.18878.f1 · Cited by 385
Self-citationProposal: Trauma as the Cause of the Peyronie's Lesion
Devine, C. J. J., Somers, K. D., Jordan, G. H., & Schlossberg, S. M. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)65361-8 · Cited by 381
The Anatomy of the Tunica Albuginea in the Normal Penis and Peyronie's Disease
Brock, G., Hsu, G.-L., Nunes, L., von Heyden, B., & Lue, T. F. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)65359-x · Cited by 226
A Retrospective Review of 307 Men With Peyronie’s Disease
Kadioglu, A., Tefekli, A., Erol, B., Oktar, T., Tunc, M., & Tellaloglu, S. (2002) · Journal of Urology · doi:10.1016/s0022-5347(05)64578-8 · Cited by 225
A Retrospective Review of 307 Men With Peyronie???s Disease
KADIOGLU, A., TEFEKLI, A., EROL, B., OKTAR, T., TUNC, M., & TELLALOGLU, S. (2002) · The Journal of Urology · doi:10.1097/00005392-200209000-00041 · Cited by 186
Peyronie’s Disease: Prevalence and Association with Cigarette Smoking
La Pera, G., Pescatori, E. S., Calabrese, M., Boffini, A., Colombo, F., Andriani, E., Natali, A., Vaggi, L., Catuogno, C., Giustini, M., et al. (2001) · European Urology · doi:10.1159/000049830 · Cited by 165
The Natural History of Peyronie’s Disease
Williams, J. L., & Thomas, G. G. (1970) · The Journal of Urology · doi:10.1016/s0022-5347(17)61894-9 · Cited by 149
Peyronie's disease cell culture models: phenotypic, genotypic and functional analyses
Mulhall, J. P., Anderson, M., LUBRANO, T., & Shankey, T. V. (2002) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900874 · Cited by 104
Self-citation
Research works printed but not linked: 1
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Cited by
The Chronology of Depression and Distress in Men with Peyronie's Disease
Nelson, C. J., Diblasio, C., Kendirci, M., Hellstrom, W., Guhring, P., & Mulhall, J. P. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00895.x · Cited by 255
Self-citationEvidence-Based Management Guidelines on Peyronie's Disease
Chung, E., Ralph, D., Kagioglu, A., Garaffa, G., Shamsodini, A., Bivalacqua, T., Glina, S., Hakim, L., Sadeghi-Nejad, H., & Broderick, G. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.04.062 · Cited by 227
Rosen, R., Catania, J., Lue, T., Althof, S., Henne, J., Hellstrom, W., & Levine, L. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00883.x · Cited by 197
Psychological Impact of Peyronie's Disease: A Review
Nelson, C. J., & Mulhall, J. P. (2013) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02999.x · Cited by 187
Self-citationMechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease
Gonzalez-Cadavid, N. F., & Rajfer, J. (2005) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0201 · Cited by 168
Metadata
- Authors
- Mulhall, J. P., Schiff, J., & Guhring, P.
- Venue
- Journal of Urology
- Published
- 2006-06
- Volume
- 175
- Issue
- 6
- Pages
- 2115-2118
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2124991789
- Cited by
- 417
- References
- 15
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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