The Influence of Anterior Root Stimulation (S2) in Deafferented Spinal Cord Injury Men on Cavernous Electrical Activity
Abstract
Registration of cavernous electrical activity (single potential analysis of cavernous electrical activity) was recently suggested for the diagnosis of autonomic cavernous dysfunction. For validation of this method the effect of sacral neurostimulation on cavernous electrical activity was examined. In 3 male patients with a complete spinal cord lesion (T3, T4 and T12, respectively), deafferentation was done at the S2 to S5 levels. Around the anterior roots of S2 to S5 electrodes for neurostimulation were placed. Cavernous electrical activity was recorded with an intracavernous needle electrode and with surface electrodes in the flaccid as well as in the erect states induced by neurostimulation (at 7, 8, 12, 18, 20, 30 and 45 Hz., 30 v. and 0.4 msec). In all patients similar potentials compared to the normal values, as well as additional pathological potentials were recorded during flaccidity. During neurostimulation all patients achieved full erection with no or markedly decreased cavernous electrical activity to frequencies of 12, 18, 20 and 30 Hz., while to 7, 8 and, more pronounced, 45 Hz. only partial erection with ongoing cavernous electrical activity was found. Our study strongly suggests that cavernous electrical activity and, subsequently, the cavernous smooth muscle tone are dependent on autonomic input. This finding supports the hypothesis that single potential analysis of cavernous electrical activity may be valid in the diagnosis of cavernous autonomic dysfunction. Furthermore, our results suggest a possible role for single potential analysis of cavernous electrical activity in the fine tuning of erection inducing neurostimulators.
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The sacral anterior root stimulator can also be used to restore male sexual and reproductive function.
“The SARS can be also used to restore male sexual and reproductive function (Stief et al., 1992; Brindley, 1995) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Stief et al., 1992
The Abstract (p. 5) says the implanted stimulator could induce penile erection, and the Discussion (p. 6) reports full erections in all three men at certain stimulation frequencies. This supports restoration of an aspect of sexual function, but the paper does not establish restoration of reproductive function, such as ejaculation or fertility. (LLM, conf=0.88)
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Applications of the Autonomic Nervous System in Clinical Practice
Košiciach, U. P. J. Š. V., Kočan, L., Rybár, D., & Rapčan, R. (2024) · Univerzita Pavla Jozefa Šafárika, Vydavateľstvo ŠafárikPress eBooks · doi:10.33542/ans-0312-8
- Authors
- Stief, C. G., Sauerwein, D., Thon, W. F., Allhoff, E. P., & Jonas, U.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- From the Department of Urology, Medizinische Hochschule Hannover, Hannover
- ORCID
- Stief, Christian G.
- Venue
- Journal of Urology
- Published
- 1992-07
- Volume
- 148
- Issue
- 1
- Pages
- 107-110
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2159430205
- Cited by
- 8
- References
- 13
- Citations by year
- 2024: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- spinal cord injury, deafferentation, erectile dysfunction
- MeSH terms
- Adult, Electric Stimulation, Humans, Male, Middle Aged, Parasympathetic Nervous System, Penile Erection, Penis, Sacrococcygeal Region, Spinal Cord Injuries
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