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Cited by 43Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentHormonal Regulation and Hypertension

Flow cytometric determinations of ploidy and proliferation patterns of adrenal neoplasms: an adjunct to histological classification

Klein, Frederick A., Kay, Saul, Ratliff, James E., White, Frances K.H., Newsome, Heber H.·1985·Journal of Urology
DOI 10.1016/s0022-5347(17)47495-7
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Abstract

Flow cytometric deoxyribonucleic acid measurements were performed with propidium iodide on 7 adrenal neoplasms and 4 normal adrenal glands to determine how useful this technique would be in defining malignancy. The 4 cases classified histologically as carcinoma all had aneuploid stemlines of 2.7, 3.3, 3.4 and 3.6c respectively, whereas the 4 normal glands and an aldosteronoma had only a small percentage (less than 10 per cent) of hyperdiploid cells (greater than 2c) at the tetraploid level (4c). A pheochromocytoma and benign adenoma had significant tetraploid populations of 30 and 18 per cent, respectively, with no evidence of aneuploid cells. Flow cytometry determination of deoxyribonucleic acid ploidy values is an accurate, objective, quantitative mean to identify adrenal malignancy and should have a role in the pathological evaluation of adrenal neoplasms.

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  • One of the first flow cytometry assessments revealed aneuploidy in 4 of 4 ACCs, yet only diploidy or tetraploidy in normal adrenal cortices and benign adrenal tumors.

    “One of the first genetic assessments with flow cytometry revealed aneuploidy (a genomic aberration consistently observed in most cancers) in 4 of 4 ACCs, yet only diploidy or tetraploidy in normal adrenal cortices and benign adrenal tumors (180).”

    From Adrenocortical carcinoma (2014) · cites this paper as [180]

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Authors
Klein, F. A., Kay, S., Ratliff, J. E., White, F. K. H., & Newsome, H. H.
Affiliations
Virginia Commonwealth University (US)
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1985-11
Volume
134
Issue
5
Pages
862-866
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1016/s0022-5347(17)47495-7
OpenAlex
W2435909319
Cited by
43
References
22
Citations by year
2015: 1 · 2013: 3
FWCI
3.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
adrenal tumors, DNA ploidy, aneuploidy, adrenocortical carcinoma, pheochromocytoma, adrenal adenoma, aldosterone-producing adenoma, tetraploidy, cell proliferation, DNA content, malignancy assessment, histological classification
MeSH terms
Adenoma, Adrenal Gland Neoplasms, Aneuploidy, Carcinoma, Cell Division, DNA, Neoplasm, Flow Cytometry, Humans, Pheochromocytoma, Ploidies

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