The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.
Nicotine-Replacement Therapy With Use of a Transdermal Nicotine Patch—a Randomized Double-Blind Placebo-Controlled Trial
Abstract
The rate of smoking was significantly reduced in volunteer subjects by providing effective nicotine replacement, self-help material, and weekly visits with a nurse for 6 weeks. Nicotine-replacement therapy with a transdermal nicotine patch (Nicolan) almost doubled the 6-week smoking-cessation rate in comparison with that in a placebo group (77% versus 39%; P = 0.002) among subjects who were smoking at least 20 cigarettes per day at baseline. Although most subjects who used the active nicotine patches had skin reactions, the reactions were primarily mild. For use of both active and placebo patches, the level of patient compliance was high. Among subjects who continued to smoke, the use of cigarettes was decreased to less than 50% of the baseline smoking level in 7 of 7 with active nicotine patches and in 15 of 19 with placebo patches. Outcomes beyond 6 weeks showed a substantial relapse rate in both groups. Thus, when nicotine-replacement therapy is provided, a need exists for concurrent behavioral intervention and training for prevention of a relapse, neither of which was part of this protocol.
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“the frequency of skin reactions is generally lower than published research on adhesive tape and patches [25-28].”
Citations
Cites
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Effect of nicotine on the tobacco withdrawal syndrome
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Compliance with hormone therapy
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CONTROLLED TRIAL OF TRANSDERMAL NICOTINE PATCH IN TOBACCO WITHDRAWAL
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META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS OF NICOTINE CHEWING-GUM
Lam, W., Sacks, H. S., SZE, P. C., & Chalmers, T. C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93061-3 · Cited by 195
Nicotine gum in smoking cessation: A placebo-controlled, double-blind trial
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Nicotine vs Placebo Gum in General Medical Practice
Hughes, J. R. (1989) · JAMA · doi:10.1001/jama.1989.03420090064032 · Cited by 133
Are Heavy Smokers Different From Light Smokers?
Killen, J. D. (1988) · JAMA · doi:10.1001/jama.1988.03410110089033 · Cited by 112
Long-term Use of Nicotine Chewing Gum
Hájek, P. (1988) · JAMA · doi:10.1001/jama.260.11.1593 · Cited by 108
Clinical and pharmacokinetic properties of a transdermal nicotine patch
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Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study
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Combination of behavioral smoking cessation with transdermal nicotine substitution
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Which smokers report most relief from craving when using nicotine chewing gum?
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Cited by
Sorted by citations
Nicotine replacement therapy for smoking cessation
Stead, L. F., Perera, R., Bullen, C., Mant, D., Hartmann‐Boyce, J., Cahill, K., & Lancaster, T. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub4 · Cited by 2,564
Nicotine replacement therapy for smoking cessation
Silagy, C., Lancaster, T., Stead, L., Mant, D., & Fowler, G. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub2 · Cited by 972
Nicotine replacement therapy for smoking cessation
Stead, L. F., Perera, R., Bullen, C., Mant, D., & Lancaster, T. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub3 · Cited by 721
Nicotine replacement therapy versus control for smoking cessation
Hartmann-Boyce, J., Chepkin, S. C., Ye, W., Bullen, C., & Lancaster, T. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub5 · Cited by 697
Management of Chronic Obstructive Pulmonary Disease
Sutherland, E. R., & Cherniack, R. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030415 · Cited by 569
Metadata
- Authors
- HURT, R. D., LAUGER, G. G., OFFORD, K. P., KOTTKE, T. E., & DALE, L. C.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- HURT, RICHARD D.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 65
- Issue
- 12
- Pages
- 1529-1537
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2008596017
- Cited by
- 113
- References
- 15
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine replacement therapy, nicotine patch, smoking cessation, relapse prevention, behavioral interventions, self-help materials, nurse visits, skin reactions, medication adherence, heavy smokers
- MeSH terms
- Administration, Cutaneous, Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Nicotine, Patient Compliance, Smoking, Substance Withdrawal Syndrome
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