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Cited by 117Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.

Nicotine-Replacement Therapy With Use of a Transdermal Nicotine Patch—a Randomized Double-Blind Placebo-Controlled Trial

HURT, RICHARD D., LAUGER, GARY G., OFFORD, KENNETH P., KOTTKE, THOMAS E., DALE, LOWELL C.·1990·Mayo Clinic Proceedings
DOI 10.1016/s0025-6196(12)62186-7
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Abstract

The rate of smoking was significantly reduced in volunteer subjects by providing effective nicotine replacement, self-help material, and weekly visits with a nurse for 6 weeks. Nicotine-replacement therapy with a transdermal nicotine patch (Nicolan) almost doubled the 6-week smoking-cessation rate in comparison with that in a placebo group (77% versus 39%; P = 0.002) among subjects who were smoking at least 20 cigarettes per day at baseline. Although most subjects who used the active nicotine patches had skin reactions, the reactions were primarily mild. For use of both active and placebo patches, the level of patient compliance was high. Among subjects who continued to smoke, the use of cigarettes was decreased to less than 50% of the baseline smoking level in 7 of 7 with active nicotine patches and in 15 of 19 with placebo patches. Outcomes beyond 6 weeks showed a substantial relapse rate in both groups. Thus, when nicotine-replacement therapy is provided, a need exists for concurrent behavioral intervention and training for prevention of a relapse, neither of which was part of this protocol.

Overview

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Crossref · 10.1016/s0025-6196(12)62186-7

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14 of 14 references verified0 citation errors · 0 not checkable

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Metadata

Authors
HURT, R. D., LAUGER, G. G., OFFORD, K. P., KOTTKE, T. E., & DALE, L. C.
Affiliations
Mayo Clinic (US)
Corresponding author
HURT, RICHARD D.
ORCID
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
1990-12
Volume
65
Issue
12
Pages
1529-1537
ISSN
0025-6196 (ISSN-L)
DOI
10.1016/s0025-6196(12)62186-7
OpenAlex
W2008596017
Cited by
113
References
15
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
9.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
nicotine replacement therapy, nicotine patch, smoking cessation, relapse prevention, behavioral interventions, self-help materials, nurse visits, skin reactions, medication adherence, heavy smokers
MeSH terms
Administration, Cutaneous, Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Nicotine, Patient Compliance, Smoking, Substance Withdrawal Syndrome

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