Negative consequences of glycation
Abstract
The Diabetes Control and Complications Trial (DCCT) established unequivocally that the effects of inadequate insulin action (as monitored by the level of hyperglycemia) are associated with the incidence and progression of diabetic retinopathy, nephropathy, and neuropathy. How does hyperglycemia induce the functional and morphologic changes that characterize diabetic complications? Increasing evidence points to a major role for sugar-derived advanced glycation end products (AGEs), which form inside and outside cells as a function of glucose concentration. Recent work in this area supports a central role for reactive oxygen species (ROS) in both the formation of AGEs, and in AGE-induced pathologic alterations in gene expression. Inhibition of ROS may also be centrally important in the action of drugs that prevent complications in diabetic animal models.
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In cigarette smokers, elevated levels of RAGE are positively correlated with the development of oral squamous cell, lung, and breast carcinoma.
“Furthermore, in cigarette smokers, elevated levels of RAGE are positively correlated with the development of oral squamous cell, lung, and breast carcinoma93,94.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [93]
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- Authors
- Brownlee, M.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Brownlee, Michael
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 49
- Issue
- 2
- Pages
- 9-13
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2140945151
- Cited by
- 284
- References
- 77
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 11 · 2013: 15 · 2012: 16
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Keywords
- advanced glycation end products, hyperglycemia, diabetes complications, reactive oxygen species, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, insulin resistance, gene expression, AGE inhibitors, Diabetes Control and Complications Trial
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Cell Communication, Extracellular Matrix, Glucose, Humans, Receptors, Immunologic, Gene Expression, Glycation End Products, Advanced
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