SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors

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Allosteric modulation of G-protein-coupled receptors

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Identify old drugs as selective bacterial β‐GUS inhibitors by structural‐based virtual screening and bio‐evaluations

Chen, Z., Xu, X., Piao, L., Chang, S., Liu, J., & Kong, R. (2019) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13655 · Cited by 11 · see citing works

G protein-coupled receptor signal transduction and Ca2+ signaling pathways of the allatotropin/orexin system in Hydra

Alzugaray, M. E., Gavazzi, M. V., & Ronderos, J. R. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113637 · Cited by 10 · see citing works

Insights from molecular dynamics simulations to exploit new trends for the development of improved opioid drugs

Filizola, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.02.037 · Cited by 11 · see citing works

Functional modulation of human delta opioid receptor by neuropeptide FF

Änkö, M., & Panula, P. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-21 · Cited by 11 · see citing works

An Efficient Solid-phase Parallel Synthesis of 2-Amino and 2-Amidobenzo[d]oxazole Derivatives via Cyclization Reactions of 2-Hydroxyphenylthiourea Resin

Jung, S.-L., Kim, S., Lee, G., & Gong, Y. (2012) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2012.33.12.4109 · Cited by 11 · see citing works

Role of the G-protein and tyrosine kinase--Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats

Wang, Y., Liang, D., Wang, S., Qiu, Z., Chu, X., Chen, S., Li, L., Nie, X., Zhang, R., Wang, Z., et al. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq010 · Cited by 8 · see citing works

Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling

Shi, L., Ko, S., Ko, M. L., Kim, A. J., & Ko, G. Y. ‐. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.02.007 · Cited by 8 · see citing works

Tryptamines as Ligands and Modulators of the Serotonin 5‑HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens

Jensen, N. (2005) · doi:10.53846/goediss-2111 · Cited by 8 · see citing works

The effect of adenosine on pro-inflammatory cytokine production by porcine T cells

Ondráčková, P., Kovaru, H., Kovaru, F., Matiašovic, J., Levá, L., & Faldyna, M. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.12.002 · Cited by 6 · see citing works

Thiadiazoles

Chiacchio, U., & Romeo, G. (2011) · doi:10.1002/9783527637737.ch14 · Cited by 5 · see citing works

Signalling pathway associated with discharge of cnidocyst induced by reduced glutathione in Hydra plagiodesmica (Dioni, 1968)

Gavazzi, M. V., Ronderos, J. R., & Alzugaray, M. E. (2023) · Canadian Journal of Zoology · doi:10.1139/cjz-2023-0114 · Cited by 4 · see citing works

Aspirin inhibits human bradykinin B2 receptor ligand binding function

Gardes, J., Michineau, S., Pizard, A., Alhenc‐Gelas, F., & Rajerison, R. M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.001 · Cited by 4 · see citing works

G Protein-Coupled Receptors

Thomsen, W. J., & Behan, D. P. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00062-6 · Cited by 4 · see citing works

Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

Chaithra, N., Swarup, H. A., Narayana, Y., Sandhya, N. C., Mantelingu, K., & Rangappa, K. S. (2021) · Synthetic Communications · doi:10.1080/00397911.2021.1986840 · Cited by 3 · see citing works

Basic Pharmacologic Principles

Chemtob, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10020-5 · Cited by 3 · see citing works

Mechanisms controlling haemolymph circulation under resting conditions in the Chagas disease vector Rhodnius prolixus

Sambucaro, M. J. V., Alzugaray, M. E., & Ronderos, J. R. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.247801 · Cited by 2 · see citing works

Identification of c[D-Trp-Phe-β-Ala-β-Ala], the First κ-Opioid Receptor-Specific Negative Allosteric Modulator

Zhao, J., Baiula, M., Cuna, E., Francescato, M., Matalińska, J., Lipiński, P. F. J., Bedini, A., & Gentilucci, L. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00372 · Cited by 2 · see citing works

Facile Synthesis of 2-Aryl-3-phenyl-5-phenylamino-2,5-dihydro-1,2,4-thiadiazole-5-carbonitriles

Aly, A. A., Nour‐el‐Din, A. M., Gomaa, M. A. ‐., & Fahmi, M. S. (2008) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426500701744876 · Cited by 2 · see citing works

Report on Biological Activities of Thiadiazole Derivatives: A Review

Semwal, A., Chaudhary, B., Singh, R., Bagchi, A., & Sahib, P. (2013) · Cited by 2 · see citing works

Allosteric enhancers for adenosine receptors

Olsson, R. A. (2003) · Drug Development Research · doi:10.1002/ddr.10198 · Cited by 2 · see citing works

Characteristics of Allosterism in Drug Action

Kenakin, T. (2006) · Informa Healthcare eBooks · doi:10.1201/9781420016185.ch2 · Cited by 2 · see citing works

Allosteric Modulators of Adenosine Receptors

Barresi, E., Giacomelli, C., Martini, C., Settimo, F. D., Trincavelli, M. L., & Taliani, S. (2022) · Topics in medicinal chemistry · doi:10.1007/7355_2022_156 · Cited by 1 · see citing works

Adenosine Receptors and Drug Discovery in the Cardiovascular System

Khayat, M. T. A., Hanif, A., Geldenhuys, W. J., & Nayeem, M. A. (2019) · Frontiers in cardiovascular drug discovery · doi:10.2174/9781681083995118040004 · Cited by 1 · see citing works

Large–scale screening of molecules involved in virus–host interaction by specific compounds in Cherax quadricarinatus hematopoietic tissue cells

Lin, W., Guo, G., Zou, C., Shi, H., & Ruan, L. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735435 · Cited by 1 · see citing works

M1 and M4 muscarinic acetylcholine receptor regulation of neurotransmission and cell excitability in rodent hippocampus and prefrontal cortex.

Shirey-Rice, J. K. (2010)

Manipulating posttranslational modification in natural product biosynthesis

Foley, T. L. (2010) · eScholarship (California Digital Library)

G Protein-Regulated Signaling Dysfunction in Human Disease

Simonds, W. F. (2003) · Journal of Investigative Medicine · doi:10.1177/108155890305100421

Mechanisms Controlling Hemolymph Circulation Under Resting Conditions In The Chagas Disease Vector Rhodnius Prolixus (Stål)Preprint

Sambucaro, M. J. V., Alzugaray, M. E., & Ronderos, J. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.19.563123

Signalling Pathway Associated to Discharge of Cnidocyst Induced by Reduced Glutathione in HydraPreprint

GAVAZZI, M. V., Ronderos, J. R., & Alzugaray, M. E. (2023) · Research Square · doi:10.21203/rs.3.rs-3015567/v1

Regulatory systems in Hydra: Serotonin, Allatotropin and Allatostatin-C crosstalk on Cnidocytes ActivityPreprint

Gavazzi, M. V., Ronderos, J. R., & Alzugaray, M. E. (2026) · Research Square · doi:10.21203/rs.3.rs-10449604/v1

BindingDB Entry 50014164: Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.

BindingDB (2009) · UC San Diego · doi:10.7270/q2xg9qj3

BindingDB Entry 50003725: Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action.

BindingDB (2020) · UC San Diego · doi:10.7270/q2222xhk

BindingDB Entry 50019821: Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2.

BindingDB (2024) · UC San Diego · doi:10.7270/q2wq085g

The ‘allosteric modulator’ SCH‐202676 disrupts G protein‐coupled receptor function <i>via</i> sulphydryl‐sensitive mechanisms

Lewandowicz, A. M., Vepsäläinen, J., & Laitinen, J. T. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706624 · Cited by 34 · see citing works

Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene)

(sch, M. H., Receptors, M. A., Lanzafame, A. A., & Christopoulos, A. (2003)

Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors

Gao, Z., Gross, A. S., & Jacobson, K. A. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.11.014 · Cited by 26 · see citing works

Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2 H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1 Muscarinic Acetylcholine Receptors

Lanzafame, A. A., & Christopoulos, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060590 · Cited by 49 · see citing works

Allosteric modulation of G-protein-coupled receptors

IJzerman, A. P., van Wijngaarden, I., & Soudijn, W. (2001) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.11.12.1889 · Cited by 13 · see citing works