The ‘allosteric modulator’ SCH‐202676 disrupts G protein‐coupled receptor function via sulphydryl‐sensitive mechanisms

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Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2 H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1 Muscarinic Acetylcholine Receptors

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Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors

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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

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PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

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Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1

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Allosteric Modulation of Purine and Pyrimidine Receptors

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A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyltransferase

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Stimulation of Electro-Olfactogram Responses in the Main Olfactory Epithelia by Airflow Depends on the Type 3 Adenylyl Cyclase

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RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

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Synthesis of 1,2,4‐Thiadiazoles by Oxidative Dimerization of Carbothioamides by Using Oxone

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Biased signaling by thyroid-stimulating hormone receptor–specific antibodies determines thyrocyte survival in autoimmunity

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Allosteric Modulators of G Protein-Coupled Dopamine and Serotonin Receptors: A New Class of Atypical Antipsychotics

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Predator cues target signaling pathways in toxic algal metabolome

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Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release

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Recent breakthroughs in synthetic small molecules targeting SARS-CoV-2 Mpro from 2022 to 2024

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A Tyrosine Residue on the TSH Receptor Stabilizes Multimer Formation

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G protein-coupled receptor signal transduction and Ca2+ signaling pathways of the allatotropin/orexin system in Hydra

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Positive allosteric modulation of µ-opioid receptor – A new possible approach in the pain management?

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A perspective on more effective GPCR-targeted drug discovery efforts

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Circulating IgGs in Type 2 Diabetes with Atrial Fibrillation Induce IP3-Mediated Calcium Elevation in Cardiomyocytes

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Allosteric Modulation of the Mu Opioid Receptor.

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Signalling Pathway Associated to Discharge of Cnidocyst Induced by Reduced Glutathione in HydraPreprint

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Regulatory systems in Hydra: Serotonin, Allatotropin and Allatostatin-C crosstalk on Cnidocytes ActivityPreprint

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Development of a Continuous Fluorescence-Based Assay for Methyltransferase-like Protein 9Preprint

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BindingDB Entry 50045701: PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

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SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors

Fawzi, A. B., Macdonald, D., Benbow, L. L., Smith-Torhan, A., Zhang, H., Weig, B. C., Ho, G., Tulshian, D., Linder, M. E., & Graziano, M. P. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12353-x · Cited by 82 · see citing works

Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene)

(sch, M. H., Receptors, M. A., Lanzafame, A. A., & Christopoulos, A. (2003)

Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2 H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1 Muscarinic Acetylcholine Receptors

Lanzafame, A. A., & Christopoulos, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060590 · Cited by 49 · see citing works

Allosteric modulation of G-protein-coupled receptors

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Structural insights into allosteric GPCR drugs

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