The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity
Abstract
Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage. We show here that a wine component, resveratrol (3,5,4'-trihydroxystilbene), is a competitive antagonist of dioxin and other AhR ligands. Resveratrol promotes AhR translocation to the nucleus and binding to DNA at dioxin-responsive elements but subsequent transactivation does not take place. Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo. Resveratrol has adequate potency and nontoxicity to warrant clinical testing as a prophylactic agent against aryl hydrocarbon-induced pathology.
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Citations
Cites
Concentration of the Phytoalexin Resveratrol in Wine
Siemann, E. H., & Creasy, L. L. (1992) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1992.43.1.49 · Cited by 719
Cited by
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii-Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 746
Metabolism and bioavailability oftrans-resveratrol
Wenzel, E., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500010 · Cited by 676
Cancer Chemopreventive Activity of Resveratrol
BHAT, K. P. L., & PEZZUTO, J. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02918.x · Cited by 398
Metadata
- Authors
- Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgrom, E., & Savouret, J.-F.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 56
- Issue
- 4
- Pages
- 784-790
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2127678138
- Cited by
- 416
- References
- 1
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity. https://app.cochat.ai/papers/10.1016/s0026-895x(24)12541-2
- The paper
- Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgrom, E., & Savouret, J.-F. (1999). Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity. Molecular Pharmacology. https://doi.org/10.1016/s0026-895x(24)12541-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
