The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Cancer Chemopreventive Activity of Resveratrol
Abstract
A bstract:Cancer chemopreventive agents are designed to reduce the incidence of tumorigenesis by intervening at one or more stages of carcinogenesis. Recently, resveratrol, a natural product found in the diet of humans, has been shown to function as a cancer chemopreventive agent. Resveratrol was first shown to act as an antioxidant and antimutagenic agent, thus acting as an anti‐initiation agent. Further evidence indicated that resveratrol selectively suppresses the transcriptional activation of cytochrome P‐450 1A1 and inhibits the formation of carcinogen‐induced preneoplastic lesions in a mouse mammary organ culture model. Resveratrol also inhibits the formation of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐promoted mouse skin tumors in the two‐stage model. The enzymatic activities of COX‐1 and ‐2 are inhibited by resveratrol in cell‐free models, and COX‐2 mRNA and TPA‐induced activation of protein kinase C and AP‐1‐mediated gene expression are suppressed by resveratrol in mammary epithelial cells. In addition, resveratrol strongly inhibits nitric oxide generation and inducible nitric oxide synthase protein expression. NFκB is strongly linked to inflammatory and immune responses and is associated with oncogenesis in certain models of cancer, and resveratrol suppresses the induction of this transcription factor by a number of agents. The mechanism may involve decreasing the phosphorylation and degradation of IκBα. At the cellular level, resveratrol also induces apoptosis, cell cycle delay or a block in the G 1→ S transition phase in a number of cell lines. Thus, resveratrol holds great promise for future development as a chemopreventive agent that may be useful for several disorders. Preclinical toxicity studies are underway that should be followed by human clinical trials.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Self-citationP450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,945
Protein Kinase C: Structure, Function, and Regulation
Newton, A. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28495 · Cited by 1,655
Gehm, B. D., McAndrews, J. M., Chien, P.-Y., & Jameson, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14138 · Cited by 1,063
Langcake, P., & Pryce, R. J. (1976) · Physiological Plant Pathology · doi:10.1016/0048-4059(76)90077-1 · Cited by 912
Manna, S. K., Mukhopadhyay, A., & Aggarwal, B. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6509 · Cited by 879
Resveratrol: A molecule whose time has come? And gone?
Soleas, G. J., Diamandis, E. P., & Goldberg, D. M. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00155-5 · Cited by 849
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Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects
Brglez Mojzer, E., Knez Hrnčič, M., Škerget, M., Knez, Ž., & Bren, U. (2016) · Molecules · doi:10.3390/molecules21070901 · Cited by 1,096
Substrate-specific activation of sirtuins by resveratrol
Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500655200 · Cited by 745
Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2364 · Cited by 688
Anticancer Efficacy of Polyphenols and Their Combinations
Niedzwiecki, A., Roomi, M., Kalinovsky, T., & Rath, M. (2016) · Nutrients · doi:10.3390/nu8090552 · Cited by 538
Metadata
- Authors
- BHAT, K. P. L., & PEZZUTO, J. M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2002-05
- Volume
- 957
- Issue
- 1
- Pages
- 210-229
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2121016657
- Cited by
- 398
- References
- 104
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
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