Identification of a novel dioxin-inducible cytochrome P450

The Aryl Hydrocarbon Receptor Complex

Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1× · see citing works

INDUCTION OF CYTOCHROME P4501A1

Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,126 · see citing works

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

Savas, Ü., Bhattacharyya, K. K., Christou, M., Alexander, D. L., & Jefcoate, C. R. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36551-1 · Cited by 206 · see citing works

Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.

Israel, D. I., & Whitlock, J. P. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44469-3 · Cited by 115 · see citing works

Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization

Dey, A., Jones, J. E., & Nebert, D. W. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00110-0 · Cited by 113 · see citing works

Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)

Rylander‐Rudqvist, T., Neve, E. P. A., Ingelman‐Sundberg, M., & Oscarson, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4390 · Cited by 106 · see citing works

Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells.

Israel, D. I., Estolano, M. G., Galeazzi, D. R., & Whitlock, J. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89072-x · Cited by 103 · see citing works

A Mutation in the Aryl Hydrocarbon Receptor (AHR) in a Cultured Mammalian Cell Line Identifies a Novel Region of AHR That Affects DNA Binding

Sun, W., Zhang, J., & Hankinson, O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31845 · Cited by 63 · see citing works

Differential Time–Course and Dose–Response Relationships of TCDD-Induced CYP1B1, CYP1A1, and CYP1A2 Proteins in Rats

Santostefano, M. J., Ross, D. G., Savas, Ü., Jefcoate, C. R. E., & Birnbaum, L. S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6389 · Cited by 56 · see citing works

A genetic analysis of processes regulating cytochrome P4501A1 expression

Hankinson, O. (1994) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(94)90015-9 · Cited by 24 · see citing works

A Novel Positive Regulatory Element That Enhances HamsterCYP2A8 Gene Expression Mediated by Xenobiotic Responsive Element

Kurose, K., Tohkin, M., & Fukuhara, M. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.2.279 · Cited by 16 · see citing works

Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

Ding, X., & Kaminsky, L. S. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140251 · Cited by 819 · see citing works

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727 · see citing works

Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

Mandal, P. K. (2005) · Journal of Comparative Physiology B · doi:10.1007/s00360-005-0483-3 · Cited by 598 · see citing works

Inhibition and induction of human cytochrome P450 enzymes: current status

Pelkonen, O., Turpeinen, M., Hakkola, J., Honkakoski, P., Hukkanen, J., & Raunio, H. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0332-8 · Cited by 571 · see citing works

Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions

Pan, C., Kumar, C., Bohl, S., Klingmueller, U., & Mann, M. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800258-mcp200 · Cited by 561 · see citing works

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

Ingelman‐Sundberg, M. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0819-z · Cited by 355 · see citing works

Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues

Bièche, I., Narjoz, C., Asselah, T., Vacher, S., Marcellin, P., Lidereau, R., Beaune, P. H., & de Waziers, I. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32810f2e58 · Cited by 339 · see citing works

Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung

Hukkanen, J., Pelkonen, O., Hakkola, J., & Raunio, H. (2002) · Critical Reviews in Toxicology · doi:10.1080/20024091064273 · Cited by 319 · see citing works

Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation

Uno, S., Dalton, T. P., Derkenne, S., Curran, C. P., Miller, M. L., Shertzer, H. G., & Nebert, D. W. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1225 · Cited by 316 · see citing works

An introduction to the molecular basics of aryl hydrocarbon receptor biology

Abel, J., & Haarmann‐Stemmann, T. (2010) · Biological Chemistry · doi:10.1515/bc.2010.128 · Cited by 297 · see citing works

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues

Choudhary, D., Jansson, I., Schenkman, J. B., Sarfarazi, M., & Stoilov, I. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00174-7 · Cited by 251 · see citing works

Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate

Uno, S., Dalton, T. P., Dragin, N., Curran, C. P., Derkenne, S., Miller, M. L., Shertzer, H. G., Gonzalez, F. J., & Nebert, D. W. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.021501 · Cited by 227 · see citing works

Human Cytochrome P450 Enzymes

Guengerich, F. P. (2007) · Springer eBooks · doi:10.1007/0-387-27447-2_10 · Cited by 220 · see citing works

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

Dauchy, S., Miller, F., Couraud, P., Weaver, R. J., Weksler, B. B., Romero, I. A., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.001 · Cited by 197 · see citing works

Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes

Thier, R., Brüning, T., Roos, P. H., Rihs, H., Golka, K., Ko, Y. D., & Bolt, H. M. (2003) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00209 · Cited by 195 · see citing works

Ah receptor signals cross-talk with multiple developmental pathways

Puga, A., Tomlinson, C. R., & Xia, Y. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.06.043 · Cited by 178 · see citing works

A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment

Lee, J., Beers, J. L., Geffert, R. M., & Jackson, K. D. (2024) · Biomolecules · doi:10.3390/biom14010099 · Cited by 177 · see citing works

The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases

Korashy, H. M., & El‐Kadi, A. O. S. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600632063 · Cited by 173 · see citing works

Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis

Kumarakulasingham, M., Rooney, P. H., Dundas, S. R., Telfer, C., Melvin, W. T., Curran, S., & Murray, G. I. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1848 · Cited by 171 · see citing works

Polymorphisms in the human AH receptor

Harper, P. A., Wong, J. M. Y., Lam, M. S. M., & Okey, A. B. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00071-6 · Cited by 167 · see citing works

Human Cytochrome P450 Enzymes

Guengerich, F. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-12108-6_9 · Cited by 150 · see citing works

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Smith, G. C., Wolf, C. R., Deeni, Y., Dawe, R. S., Evans, A. T., Comrie, M., Ferguson, J., & Ibbotson, S. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13081-4 · Cited by 147 · see citing works

Role of the aryl hydrocarbon receptor in drug metabolism

Ramadoss, P., Marcus, C. B., & Perdew, G. H. (2005) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.1.1.9 · Cited by 144 · see citing works

Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical

Sinz, M., Wallace, G., & Sahi, J. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9037-4 · Cited by 143 · see citing works

The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

Fleming, I. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007781 · Cited by 140 · see citing works

Function of human cytochrome P450s: Characterization of the orphans

Guengerich, F. P., Wu, Z., & Bartleson, C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.079 · Cited by 133 · see citing works

The human genome project and novel aspects of cytochrome 450 research

Ingelman‐Sundberg, M. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.030 · Cited by 125 · see citing works

Expression of Xenobiotic Metabolizing Enzymes in Different Lung Compartments of Smokers and Nonsmokers

Thum, T., Erpenbeck, V. J., Moeller, J., Hohlfeld, J. M., Krug, N., & Borlak, J. T. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8861 · Cited by 123 · see citing works

Timing is everything: Consequences of transient and sustained AhR activity

Mitchell, K. A., & Elferink, C. J. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.028 · Cited by 120 · see citing works

Cyp1a1(−/−) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria

Uno, S. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.01.014 · Cited by 115 · see citing works

CYP2S1: A short review

Saarikoski, S. T., Rivera, S. P., Hankinson, O., & Husgafvel‐Pursiainen, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.027 · Cited by 109 · see citing works

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

D’Ambrosio, D. N., Walewski, J. L., Clugston, R. D., Berk, P. D., Rippe, R. A., & Blaner, W. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024993 · Cited by 108 · see citing works

Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology

Guengerich, F. P., & Cheng, Q. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003525 · Cited by 103 · see citing works

Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective

Swanson, H. I. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.08.006 · Cited by 103 · see citing works

Cytochrome P450 1 Genes in Early Deuterostomes (Tunicates and Sea Urchins) and Vertebrates (Chicken and Frog): Origin and Diversification of the CYP1 Gene Family

Goldstone, J. V., Goldstone, H. M. H., Morrison, A. M., Tarrant, A. M., Kern, S. E., Woodin, B. R., & Stegeman, J. J. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm200 · Cited by 102 · see citing works

Novel extrahepatic cytochrome P450s

Karlgren, M., MIURA, S., & Ingelman‐Sundberg, M. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.022 · Cited by 101 · see citing works

Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1

Wu, Z., Sohl, C. D., Shimada, T., & Guengerich, F. P. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023648 · Cited by 99 · see citing works

Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

Anwar‐Mohamed, A., Elbekai, R. H., & El‐Kadi, A. O. S. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250902918302 · Cited by 92 · see citing works

tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand

Gharavi, N., & El-Kadi, A. O. S. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002253 · Cited by 87 · see citing works

The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+

Elbekai, R. H., & El‐Kadi, A. O. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.07.012 · Cited by 85 · see citing works

Cytochrome P4501A1 Promotes G1 Phase Cell Cycle Progression by Controlling Aryl Hydrocarbon Receptor Activity

Levine, A., Chen, L., & Elferink, C. J. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.2.461 · Cited by 84 · see citing works

Extrahepatic metabolism at the body's internal–external interfaces

Gundert‐Remy, U., Bernauer, U., Blömeke, B., Döring, B., Fabian, E. J., Goebel, C., Hessel‐Pras, S., Jäckh, C., Lampen, A., Oesch, F., et al. (2014) · Drug Metabolism Reviews · doi:10.3109/03602532.2014.900565 · Cited by 82 · see citing works

The aryl hydrocarbon receptor and light

Rannug, A., & Fritsche, E. (2006) · Biological Chemistry · doi:10.1515/bc.2006.143 · Cited by 79 · see citing works

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models

Oesch, F., Fabian, E. J., & Landsiedel, R. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02602-7 · Cited by 76 · see citing works

CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody

Zhu, L.-R., Thomas, P. E., Lǚ, G., Reuhl, K. R., Yang, G., Wang, L., Wang, S.-L., Yang, C. S., He, X., & Hong, J. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011049 · Cited by 74 · see citing works

Epidermal CYP2 family cytochromes P450

Du, L., Hoffman, S. M. G., & Keeney, D. S. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.09.020 · Cited by 74 · see citing works

A Novel Promoter Element Containing Multiple Overlapping Xenobiotic and Hypoxia Response Elements Mediates Induction of Cytochrome P4502S1 by Both Dioxin and Hypoxia

Rivera, S. P., Wang, F., Saarikoski, S. T., Taylor, R. T., Chapman, B., Zhang, R., & Hankinson, O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609617200 · Cited by 71 · see citing works

Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids

Bui, P. H., Imaizumi, S., Beedanagari, S. R., Reddy, S. T., & Hankinson, O. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035121 · Cited by 68 · see citing works

Characterization of Orphan Human Cytochromes P450

Stark, K., & Guengerich, F. P. (2007) · Drug Metabolism Reviews · doi:10.1080/03602530701467708 · Cited by 68 · see citing works

Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium

Elbekai, R. H., & El‐Kadi, A. O. S. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.05.009 · Cited by 65 · see citing works

Skin Retinoid Concentrations Are Modulated by CYP26AI Expression Restricted to Basal Keratinocytes in Normal Human Skin and Differentiated 3D Skin Models

Heise, R., Mey, J., Neis, M. M., Marquardt, Y., Joussen, S., Ott, H., Wiederholt, T., Kurschat, P., Megahed, M., Bickers, D. R., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700432 · Cited by 65 · see citing works

Localization of Cytochrome P450 CYP2S1 Expression in Human Tissues by In Situ Hybridization and Immunohistochemistry

Saarikoski, S. T., Wikman, H., Smith, G. C., Wolff, C. H. J., & Husgafvel‐Pursiainen, K. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.4c6576.2005 · Cited by 65 · see citing works

Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens

Blankenship, A. L., Hilscherová, K., Nie, M., Coady, K. K., Villalobos, S. A., Kannan, K., Powell, D. C., Bursian, S. J., & Giesy, J. P. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00166-2 · Cited by 64 · see citing works

Aryl hydrocarbon receptor‐dependent induction of apoptosis by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in cerebellar granule cells from mouse

Sánchez-Martín, F. J., Fernández‐Salguero, P. M., & Merino, J. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07291.x · Cited by 56 · see citing works

Regulation of the Cyp2a5 Gene Involves an Aryl Hydrocarbon Receptor-Dependent Pathway

Arpiainen, S., Raffalli‐Mathieu, F., Lang, M. A., Pelkonen, O., & Hakkola, J. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008078 · Cited by 56 · see citing works

Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells

Taylor, R. T., Wang, F., Hsu, E. L., & Hankinson, O. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn217 · Cited by 54 · see citing works

Overexpression of latent transforming growth factor-β binding protein 1 (LTBP-1) in dioxin receptor-null mouse embryo fibroblasts

Santiago‐Josefat, B., Mulero‐Navarro, S., Dallas, S. L., & Fernández‐Salguero, P. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.00932 · Cited by 53 · see citing works

Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

Frömel, T., Kohlstedt, K., Popp, R., Yin, X., Awwad, K., Barbosa‐Sicard, E., Thomas, A. C., Lieberz, R., Mayr, M., & Fleming, I. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0319-8 · Cited by 50 · see citing works

Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly(ADP-ribose) polymerase: Role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor

Ma, Q. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00339-9 · Cited by 50 · see citing works

Fatty Acid Hydroperoxides Support Cytochrome P450 2S1-Mediated Bioactivation of Benzo[a]pyrene-7,8-dihydrodiol

Bui, P. H., Hsu, E. L., & Hankinson, O. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.057760 · Cited by 49 · see citing works

Functional Characterization of Human Cytochrome P450 2S1 Using a Synthetic Gene-Expressed Protein in Escherichia coli

Bui, P. H., & Hankinson, O. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.057752 · Cited by 49 · see citing works

Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy

Singh, R., Avadhesh, A., Sharma, G., Dholariya, S. J., Shah, R., Goyal, B., & Gupta, S. C. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0116 · Cited by 46 · see citing works

High-Throughput Screening for Drug Discovery

Saxena, S. K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.91075 · Cited by 46 · see citing works

Reassessing the evidence for the link between dioxin and endometriosis: from molecular biology to clinical epidemiology

Guo, S., Simsa, P., Kyama, C. M., Mihalyi, A., Fulop, V., Othman, E.-E. R., & D’Hooghe, T. M. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap075 · Cited by 45 · see citing works

Characterization of the Human Lung CYP2F1 Gene and Identification of a Novel Lung-specific Binding Motif

Carr, B., Wan, J., Hines, R. N., & Yost, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300319200 · Cited by 45 · see citing works

Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice

Anwar‐Mohamed, A., Abdelhamid, G., Amara, I. E. A., & El‐Kadi, A. O. S. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0855-x · Cited by 39 · see citing works

Reduction of Aromatic and Heterocyclic AromaticN-Hydroxylamines by Human Cytochrome P450 2S1

Wang, K., & Guengerich, F. P. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400139p · Cited by 39 · see citing works

HUMAN CYTOCHROME P450 2S1: LACK OF ACTIVITY IN THE METABOLIC ACTIVATION OF SEVERAL CIGARETTE SMOKE CARCINOGENS AND IN THE METABOLISM OF NICOTINE

Wang, S., He, X., & Hong, J. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002923 · Cited by 37 · see citing works

Benzo[a]pyrene impedes self-renewal and differentiation of mesenchymal stem cells and influences fracture healing

Zhou, Y., Jiang, R., An, L., Wang, H., Cheng, S., Shi, Q., & Weng, Y. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.02.152 · Cited by 37 · see citing works

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Al‐Majdoub, Z. M., Couto, N. A. S., Achour, B., Harwood, M. D., Carlson, G., Warhurst, G., Barber, J., & Rostami‐Hodjegan, A. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2097 · Cited by 36 · see citing works

Detection of electrophoretically separated cytochromes P450 by element-labelled monoclonal antibodies via laser ablation inductively coupled plasma mass spectrometry

Roos, P. H., Venkatachalam, A., Manz, A., Waentig, L., Koehler, C. U., & Jakubowski, N. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2242-2 · Cited by 35 · see citing works

Recruitment of CREB1 and Histone Deacetylase 2 (HDAC2) to the Mouse Ltbp-1 Promoter Regulates its Constitutive Expression in a Dioxin Receptor-dependent Manner

Gómez-Durán, Á., Ballestar, E., Carvajal-González, J. M., Marlowe, J. L., Puga, A., Esteller, M., & Fernández‐Salguero, P. M. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.056 · Cited by 34 · see citing works

Theophylline pharmacokinetics: comparison of Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice

Derkenne, S., Curran, C. P., Shertzer, H. G., Dalton, T. P., Dragin, N., & Nebert, D. W. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000167326.00411.50 · Cited by 34 · see citing works

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms

Anwar‐Mohamed, A., Elshenawy, O. H., Soshilov, A. A., Denison, M. S., Le, X. C., Klotz, L., & El‐Kadi, A. O. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.810 · Cited by 33 · see citing works

Catalog of 680 variations among eight cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population

Saito, S., Iida, A., Sekine, A., Kawauchi, S., Higuchi, S., Ogawa, C., & Nakamura, Y. (2003) · Journal of Human Genetics · doi:10.1007/s10038-003-0021-7 · Cited by 30 · see citing works

Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase

Xiao, Y., Shinkyo, R., & Guengerich, F. P. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.039321 · Cited by 29 · see citing works

Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers

Dörrenhaus, A., Müller, T., & Roos, P. H. (2006) · Archives of Toxicology · doi:10.1007/s00204-006-0134-9 · Cited by 28 · see citing works

Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells

Thomas, R. D., Green, M. R., Wilson, C., Weckle, A. L., Duanmu, Z., Kocarek, T. A., & Runge‐Morris, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.01.007 · Cited by 28 · see citing works

Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R., & Smith, G. C. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.042085 · Cited by 27 · see citing works

Down‐regulation of aryl hydrocarbon receptor–regulated genes by tumor necrosis factor‐α and lipopolysaccharide in murine hepatoma hepa 1c1c7 cells

Gharavi, N., & El‐Kadi, A. O. S. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20267 · Cited by 27 · see citing works

Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis

Madanayake, T. W., Fidler, T. P., Fresquez, T., Bajaj, N., & Rowland, A. M. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046466 · Cited by 23 · see citing works

The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver

Mescher, M., Tigges, J., Rolfes, K. M., Shen, A. L., Yee, J. S., Vogeley, C., Krutmann, J., Bradfield, C. A., Lang, D. H., & Haarmann‐Stemmann, T. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02488-5 · Cited by 23 · see citing works

Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species

Hu, S., Wang, H., Knisely, A. A., Reddy, S., Kovacevic, D., Liu, Z. Y., & Hoffman, S. M. G. (2007) · Genetica · doi:10.1007/s10709-007-9206-x · Cited by 22 · see citing works

AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells

Roblin, S., Okey, A. B., & Harper, P. A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.016 · Cited by 22 · see citing works

The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis

Kuznetsov, N., Andersson, P., Gradin, K., von Stein, P., Dieckmann, A., Pettersson, S., Hanberg, A., & Poellinger, L. (2005) · Oncogene · doi:10.1038/sj.onc.1208529 · Cited by 23 · see citing works

Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: Its regulation by aryl hydrocarbon receptor agonists

Deb, S., & Bandiera, S. M. (2009) · Toxicology · doi:10.1016/j.tox.2009.10.025 · Cited by 21 · see citing works

CYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers

Li, Y., Su, X., Feng, C., Liu, S., Guan, H., Sun, Y., He, N., Ji, M., & Hou, P. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00231-6 · Cited by 21 · see citing works

CYP2S1 depletion enhances colorectal cell proliferation is associated with PGE2-mediated activation of β-catenin signaling

Yang, C., Li, C.-Y., Li, M., Tong, X., Hu, X., Yang, X., Yan, X., He, L., & Wan, C. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.12.008 · Cited by 21 · see citing works

MOLECULAR MECHANISMS REGULATING HUMAN CYP4B1 LUNG-SELECTIVE EXPRESSION

Poch, M. T., Cutler, N. S., Yost, G. S., & Hines, R. N. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.004523 · Cited by 21 · see citing works

Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As3+, Cd2+ and Cr6+

Elbekai, R. H., Duke, J., & El‐Kadi, A. O. S. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.01.029 · Cited by 20 · see citing works

Role of Nitric Oxide in Downregulation of Cytochrome P450 1a1 and NADPH: Quinone Oxidoreductase 1 by Tumor Necrosis Factor‐α and Lipopolysaccharide

Gharavi, N., & El‐Kadi, A. O. S. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20910 · Cited by 19 · see citing works

Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population

Saarikoski, S. T., Suitiala, T., Holmila, R. J., Impivaara, O., Järvisalo, J. O., Hirvonen, A., & Husgafvel‐Pursiainen, K. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.007 · Cited by 18 · see citing works

The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons

Riddick, D. S., Lee, C., Bhathena, A., & Timsit, Y. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y03-003 · Cited by 17 · see citing works

Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications

Elbekai, R. H., & El‐Kadi, A. O. S. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.03.010 · Cited by 16 · see citing works

Differential modulation of cytochrome P450 1a1 by arsenite in vivo and in vitro in C57BL/6 mice

Anwar‐Mohamed, A., Abdelhamid, G., Amara, I. E. A., & El‐Kadi, A. O. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.012 · Cited by 16 · see citing works

Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes

Lemm, F., Wilhelm, M., & Roos, P. H. (2004) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00298 · Cited by 16 · see citing works

Identification of novel dioxin-responsive genes by representational difference analysis

Rivera, S. P., Saarikoski, S. T., Sun, W., & Hankinson, O. (2007) · Xenobiotica · doi:10.1080/00498250601169816 · Cited by 16 · see citing works

Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator‑activated receptor‑γ expression and liver disease

Ismael, L. Q., Abdulhameed, A.-S. A. R., Keong, Y., Abdullah, M. N., Bahari, H., Jie, T., & Yin, K. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11671 · Cited by 15 · see citing works

A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach

Fekry, M. I., Xiao, Y., Berg, J. Z., & Guengerich, F. P. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.089086 · Cited by 15 · see citing works

Characterization and expression of extrahepatic CYP2S1

Deb, S., & Bandiera, S. M. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250902865586 · Cited by 15 · see citing works

A Novel Promoter Element Containing Multiple Overlapping Xenobiotic and Hypoxia Response Elements Mediates Induction of Cytochrome P4502S1 by Both Dioxin and Hypoxia

Rivera, S. P., Wang, F., Saarikoski, S. T., Taylor, R. T., Chapman, B., Zhang, R., & Hankinson, O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609617200 · Cited by 71 · see citing works

INDUCTION OF CYTOCHROME P4501A1

Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,126 · see citing works

CYP2S1: A short review

Saarikoski, S. T., Rivera, S. P., Hankinson, O., & Husgafvel‐Pursiainen, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.027 · Cited by 109 · see citing works

Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines

Beedanagari, S. R., Taylor, R. T., & Hankinson, O. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.01.019 · Cited by 30 · see citing works

635 Second tumors after treatment for Hodgkin's lymphoma (HL) in children

Safonova, S., Malinin, A., & Punanov, Y. А. (2003) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(03)90667-7