The DOI matches its Crossref record.
Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones
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“When iron is present in the cytosol (as may occur more frequently with ageing)265,266, dopamine can be oxidized into dopamine quinone (DAQ), which is highly reactive and toxic267,268.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [267]
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Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
“Dopaminerincreased expression and subcellular redistribution of gic neurons may be a particularly fertile environment for the anti-PCD protein Bcl-xL and with activated PCDthe generation of ROS, as the metabolism of DA produces effector protease caspase-3 have also been found inhydrogen peroxide and superoxide radical…”
BackgroundOxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
“The presence of neuromelanin in dopaminergic cells attracted attention to the autoxidation of dopamine, semiquinone formation, and polymerization through which radical species are produced.(36,37) This led to the concept that the metabolism of dopamine might be responsible for the high basal levels of oxidative stress…”
BackgroundThe Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
“Perturbations in this step again impact the levels of cytoplasmic free dopamine that is susceptible to be oxidized [64, 65].”
Background
Metadata
- Authors
- GRAHAM, D. G.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- GRAHAM, DOYLE G.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1978-07
- Volume
- 14
- Issue
- 4
- Pages
- 633-643
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2211987820
- Cited by
- 1,126
- References
- 0
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 26 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 26 · 2013: 26 · 2012: 49
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- catecholamines, autoxidation, periodate oxidation, 6-hydroxydopamine, dopamine, norepinephrine, epinephrine, aminochrome, adrenochrome, o-quinones, p-quinones, cyclization, tautomerism, neuromelanin
- MeSH terms
- Catecholamines, Dopamine, Epinephrine, Hydroxydopamines, Melanins, Norepinephrine, Oxidation-Reduction, Quinones, Monophenol Monooxygenase
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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