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The Binding of Agonists to Brain Muscarinic Receptors
Abstract
The interaction of agonists with muscarinic receptors has been investigated by measuring the binding of [3H]muscarinic agonists to membrane preparations from the rat cortex and by means of [3H]agonist/agonist and [3H]antagonist/agonist competition experiments. The binding data can be explained by the presence of two major populations of agonist binding sites which do not interconvert during the binding experiments and have the same affinity constants for antagonists. The ratio of the affinity constants of an agonist for the two sites can vary from 1 to about 275. There is quantitative agreement between the agonist affinity constants for the two sites and parameters derived from the action of muscarinic agonists on smooth muscle, A third (minor) population of "super-high" affinity agonist binding sites has been detected.
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Cited by
Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem
Wamsley, J., Lewis, M., Young, W., & Kuhar, M. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-02-00176.1981 · Cited by 377
Lysakowski, A., Wainer, B. H., Bruce, G., & Hersh, L. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90180-2 · Cited by 239
Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists
Bordin, S., Boschero, A. C., Carneiro, E. M., & Atwater, I. (1995) · The Journal of Membrane Biology · doi:10.1007/bf00207273 · Cited by 67
Metadata
- Authors
- BIRDSALL, N. J. M., BURGEN, A. S. V., & HULME, E. C.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1978-09
- Volume
- 14
- Issue
- 5
- Pages
- 723-736
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W1855289338
- Cited by
- 673
- References
- 0
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Binding of Agonists to Brain Muscarinic Receptors. https://app.cochat.ai/papers/10.1016/s0026-895x(25)13545-1
- The paper
- BIRDSALL, N. J. M., BURGEN, A. S. V., & HULME, E. C. (1978). The Binding of Agonists to Brain Muscarinic Receptors. Molecular Pharmacology. https://doi.org/10.1016/s0026-895x(25)13545-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
