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Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts.
Abstract
The spin trapping of superoxide by nitrone spin traps, in particular 5,5-dimethyl-1-pyrroline-1-oxide (DMPO), was found to lead to the de novo production of hydroxyl radical and a nonradical species. Hydroxyl radical is then spin-trapped by DMPO, producing DMPO-OH. It was determined that a background level of approximately 3% DMPO-OH relative to DMPO-OOH is produced by this mechanism. Thus, the detection of hydroxyl radical by spin trapping with DMPO must be used with caution if the level of hydroxyl radical is less than 3% of the rate of superoxide generation. Several examples are cited in which investigators suggested that hydroxyl radical is produced when in fact the spin trapping of this free radical may have been an artifact of the system.
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Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Generation and Detection of Reactive Oxygen Species in Photocatalysis
Nosaka, Y., & Nosaka, A. Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00161 · Cited by 4,771
Spin Trapping: ESR parameters of spin adducts 1474 1528V
Buettner, G. R. (1987) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(87)80033-3 · Cited by 1,827
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Generation of superoxide by purified brain nitric oxide synthase
Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750
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Metadata
- Authors
- Finkelstein, E., Rosen, G. M., & Rauckman, E. J.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1982-03
- Volume
- 21
- Issue
- 2
- Pages
- 262-265
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2309733666
- Cited by
- 297
- References
- 0
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Finkelstein, E., Rosen, G. M., & Rauckman, E. J. (1982). Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts. Molecular Pharmacology. https://doi.org/10.1016/s0026-895x(25)14604-x
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