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Cited by 110Prenatal Screening and DiagnosticsParvovirus B19 Infection StudiesPreterm Birth and Chorioamnionitis

Intrauterine viral infection at the time of second trimester genetic amniocentesis

Wenstrom, K·1998·Obstetrics & Gynecology
DOI 10.1016/s0029-7844(98)00210-5
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Abstract

OBJECTIVE: To determine whether preexisting intrauterine viral infection is associated with postamniocentesis pregnancy loss. METHODS: We accessed our bank of second-trimester amniotic fluid (AF) samples obtained aseptically and stored at -20C from all 11,971 women who underwent genetic amniocentesis between 1988 and 1995. Samples were retrieved from every case of spontaneous pregnancy loss within 30 days of the amniocentesis (excluding aneuploidy and anomalies, n = 66). Sixty-six control samples were randomly chosen from subjects who delivered at term and were matched for year of test, gestational age, maternal age, and indication for amniocentesis. Investigators were blinded to the status of the samples, which were studied by polymerase chain reaction (PCR) for the presence of adenovirus, parvovirus, cytomegalovirus, Epstein-Barr virus, herpes simplex virus, enterovirus, influenza A virus, and beta-actin DNA. Results were compared with interleukin-6 (IL-6) levels previously measured by enzyme-linked immunosorbent assay in the same samples. RESULTS: Sixty-two study cases and 60 controls were sufficient for all PCR studies. Fourteen AF samples contained a single virus: five (8%) of 62 study cases and nine (15%) of 60 controls (P = .27). Adenovirus accounted for nine (64%) of 14 viruses identified: four of 62 cases and five of 60 controls (P = .74). Cytomegalovirus was not identified in any study cases but was found in three controls. The mean IL-6 levels in samples with and without virus were not significantly different (4.8+/-15.9 ng/mL with virus compared with 2.0+/-8.8 ng/mL without virus; P = .53). CONCLUSION: Presence of virus in second-trimester AF is not significantly associated with elevated IL-6 levels or with early postamniocentesis pregnancy loss.

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  • Viral DNAs in the amniotic fluid of asymptomatic women undergoing genetic amniocentesis were generally unrelated to subsequent preterm births, so it seems unlikely that maternal viral infection plays an important part in preterm birth.

    “In several studies, the viral DNAs—identified by PCR techniques—in the amniotic fluid of asymptomatic women undergoing genetic amniocentesis were generally unrelated to subsequent preterm births;115 therefore, it seems unlikely that maternal viral infection plays an important part in preterm birth, but controversy persists, and with little information, further study is needed.116”

    From Epidemiology and causes of preterm birth (2008) · cites this paper as [115]

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Authors
Wenstrom, K.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Wenstrom, K
Venue
Obstetrics & Gynecology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-09
Volume
92
Issue
3
Pages
420-424
ISSN
0029-7844 (ISSN-L)
DOI
10.1016/s0029-7844(98)00210-5
OpenAlex
W2072696691
Cited by
110
References
20
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 8
FWCI
2.15
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
Keywords
intrauterine viral infection, amniocentesis, second trimester, spontaneous pregnancy loss, amniotic fluid, interleukin-6, adenovirus, cytomegalovirus, herpes simplex virus, Epstein-Barr virus, parvovirus, enterovirus, influenza A virus, viral DNA detection
MeSH terms
Abortion, Spontaneous, Amniocentesis, Amniotic Fluid, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Trimester, Second, Virus Diseases, Interleukin-6, Polymerase Chain Reaction

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