The Staging and Surgery of Musculoskeletal Neoplasms

Wolf, Robert E.; Enneking, William F.

doi:10.1016/s0030-5898(20)32093-9

Cited by 125Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCancer Diagnosis and Treatment

The Staging and Surgery of Musculoskeletal Neoplasms

Wolf, Robert E., Enneking, William F.·1996·Orthopedic Clinics of North America

DOI 10.1016/s0030-5898(20)32093-9

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Abstract

This review has outlined the surgical staging of benign and malignant musculoskeletal neoplasms. Based on their unique natural history, these neoplasms behave in a predictable fashion. The surgical staging system assigns progressively higher degrees of risks to the neoplasms based on their surgical grade, their anatomic location, and the presence or absence of metastases. The staging system articulates well with preoperative planning, defining the margins needed for local tumor control. Because surgery distorts most of the imaging modalities available, all clinical staging studies must be completed before surgical intervention. As more data accrue as to the importance of DNA ploidy, genetic markers, and other characteristics, it is likely they will play an important role in the diagnosis and treatment of musculoskeletal neoplasms in the future.

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Staging is guided primarily by the MSTS staging system for sarcomas, which defines tumours as low or high grade, confined to an anatomic compartment or violating barriers, and localized or metastatic.
“Staging is guided primarily by the Musculoskeletal Tumour Society (MSTS) staging system for sarcomas 108 , which defines tumours as being either low or high grade, confined to an anatomic compartment or violating anatomic barriers, and localized or metastatic.”
From Osteosarcoma (2022) · cites this paper as [108]

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Authors: Wolf, R. E., & Enneking, W. F.
Affiliations: University of Louisville (US)
University of Florida Health (US)
Corresponding author: Enneking, William F.
Venue: Orthopedic Clinics of North America
Publisher: Elsevier BV
Published: 1996-07
Volume: 27
Issue: 3
Pages: 473-481
ISSN: 0030-5898 (ISSN-L)
DOI: 10.1016/s0030-5898(20)32093-9
OpenAlex: W2467947662
Cited by: 125
References: 19
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 8
FWCI: 3.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Orthopedic Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
Keywords: musculoskeletal neoplasms, surgical staging, preoperative staging, metastasis, surgical margins, local tumor control, benign and malignant tumors, DNA ploidy, genetic markers, surgical planning
MeSH terms: Bone Neoplasms, Child, Extremities, Humans, Neoplasm Staging, Surgical Procedures, Operative, Muscle Neoplasms

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The Staging and Surgery of Musculoskeletal Neoplasms

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