Benzodiazepines (BZs)2 are used clinically as muscle relaxants, anticonvulsants, anxiolytics, and sedative-hypnotics. These effects are mediated primarily via the central BZ receptors (CBRs) located in the central nervous system (CNS;[Braestrup and Squires, 1977][1]; [Mohler and Okada, 1977][2]; [