Bioregulation of kinins: kallikreins, kininogens, and kininases.
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Bradykinin is rapidly degraded in the plasma of healthy individuals by angiotensin I-converting enzyme (ACE) and aminopeptidase P (APP).
“BK is rapidly degraded in the plasma of healthy individuals by angiotensin I-converting enzyme (ACE) and aminopeptidase P (APP) (Bhoola et al. 1992).”
From A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. (2005) · cites this paper as Bhoola et al. 1992
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The Kallikrein-Kinin System: Current and Future Pharmacological Targets
Moreau, M. E., Garbacki, N., Molinaro, G., Brown, N. J., Marceau, F., & Adam, A. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.srj05001x · Cited by 457 · see citing works
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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
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Molinaro, G., Cugno, M., Perez, M., Lepage, Y., Gervais, N., Agostoni, A., & Adam, A. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038067 · Cited by 137 · see citing works
The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins
Blais, C., Marceau, F., Rouleau, J.-L., & Adam, A. (2000) · Peptides · doi:10.1016/s0196-9781(00)00348-x · Cited by 135 · see citing works
Duan, Q. L., Nikpoor, B., Dubé, M.-P., Molinaro, G., Meijer, I. A., Dion, P., Rochefort, D., Saint-Onge, J., Flury, L., Brown, N. J., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/496899 · Cited by 126 · see citing works
Emanueli, C., Grady, E. F., Madeddu, P., Figini, M., Bunnett, N. W., Parisi, D., Regoli, D., & Geppetti, P. (1998) · Hypertension · doi:10.1161/01.hyp.31.6.1299 · Cited by 114 · see citing works
Blais, C., Marc–Aurèle, J., Simmons, W. H., Loute, G., Thibault, P., Skidgel, R. A., & Adam, A. (1999) · Peptides · doi:10.1016/s0196-9781(99)00020-0 · Cited by 60 · see citing works
Yiu, W. H., Wong, D. W. L., Chan, L. Y. Y., Leung, J. C. K., Chan, K. W., Lan, H. Y., Lai, K. N., & Tang, S. C. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088894 · Cited by 50 · see citing works
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Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors
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Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells
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Dai, S.-H., Li, J.-F., Feng, J.-B., Li, R.-J., Li, C.-B., Li, Z., Zhang, Y., & Li, D.-Q. (2016) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320316655037 · Cited by 11 · see citing works
- Authors
- Bhoola, K. D., Figueroa, C. D., & Worthy, K.
- Affiliations
- University of Bristol (GB)
- ORCID
- Figueroa, C D
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 44
- Issue
- 1
- Pages
- 1-80
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W1764686129
- Cited by
- 1,744
- References
- 0
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 16 · 2021: 14 · 2020: 22 · 2019: 20 · 2018: 21 · 2017: 25 · 2016: 33 · 2015: 35 · 2014: 40 · 2013: 37 · 2012: 43
- FWCI
- 30.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pineapple and bromelain studies
- Keywords
- kinins, kallikrein-kinin system, kallikrein, kininogen, kininase, bradykinin, bradykinin B2 receptor, bradykinin B1 receptor, bradykinin degradation
- MeSH terms
- Animals, Lysine Carboxypeptidase, Humans, Kallikreins, Peptidyl-Dipeptidase A, Kininogens, Tissue Distribution, Mice, Rats
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