Comparative analysis of anxiety-like behavior in partition and plus-maze tests after agonistic interactions in mice
Abstract
The behavior of C57BL/6J male mice with experience of repeated victories (winners) or defeats (losers) in daily agonistic interactions, was examined in the plus-maze and partition tests. The latter procedure assesses the reactivity of mice to another conspecific in the neighboring compartment of a common cage, communicative behavior or level of sociability. The behavior of mice after 10 days (T10) and 20 days (T20) of agonistic confrontations, as well as in controls (5 days of individual housing) was analyzed. Significant differences were found between T10 and T20 losers and controls in both tests. In the partition test, a decrease in the number of approaches and total and average time spent near the partition was found in T10 and, more pronounced, in T20 losers. In the plus-maze, losers showed fewer open and total entries than controls. Moreover, rarely did they pass from one enclosed arm to another, and also showed a decreased number of 'peepings' from enclosed arms. Percentage of open time did not differ significantly in losers compared to controls. It is suggested that the level of losers' sociability, estimated as low by the partition test, can include anxiety as a component, which is confirmed, at least partly, by some parameters of the plus-maze test. There were no differences in the partition or plus-maze tests between T10 winners and controls. However, all parameters of partition behavior were significantly different between T20 winners and controls. In the plus-maze…
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A modified and abbreviated version of the sensory contact model of social defeat stress in mice, initially described by Kudryavtseva and co-workers, was introduced in 2006 by Berton et al.
“A modified and abbreviated version of the sensory contact model of social defeat stress in mice, initially described by Kudryavtseva and co-workers10,22, was introduced in 2006 by Berton et al.17.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [22]
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Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour
File, S. E. (2008) · Neuropsychobiology · doi:10.1159/000118163 · Cited by 141 · see citing works
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A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
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Blanchard, R. J., McKittrick, C. R., & Blanchard, D. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00449-8 · Cited by 595 · see citing works
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Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress
Hanke, M. L., Powell, N. D., Stiner, L. M., Bailey, M. T., & Sheridan, J. F. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.011 · Cited by 143 · see citing works
- Authors
- Avgustinovich, D. F., Gorbach, O. V., & Kudryavtseva, N. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Avgustinovich, Damira F.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 61
- Issue
- 1
- Pages
- 37-43
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2007604466
- Cited by
- 102
- References
- 1
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 5
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- anxiety-like behavior, agonistic behavior, plus-maze test, sociability, winners and losers, repeated social defeat, C57BL/6J mice, open arm entries, anxiety assessment
- MeSH terms
- Agonistic Behavior, Animals, Animal Communication, Anxiety, Arousal, Disease Models, Animal, Dominance-Subordination, Escape Reaction, Male, Mice, Inbred C57BL, Social Behavior, Social Environment, Maze Learning, Mice
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