Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice
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The experimental model, social disruption (SDR), is a model of social stress in which mice are repeatedly attacked and defeated in their home cage by an aggressive conspecific. In terms of the impact of this stressor on the immune response, SDR has been reported to cause hyperinflammation and glucocorticoid insensitivity. To this point however, the behavioral consequences of SDR have not been thoroughly characterized. Because social defeat has been reported to cause anxiety- and depressive-like behaviors, the current study was designed to assess whether SDR also causes anxiety- and depressive-like behaviors. Using the light/dark preference test and the open field test as tools to measure behaviors characteristic of anxiety, the data showed that C57BL/6 and CD-1 male mice subjected to SDR displayed increased anxiety-like behavior. The increase in anxiety-like behaviors persisted for at least 1 week after the cessation of the stressor. In contrast, depressive-like behaviors were not elicited by SDR as assessed by the forced swim test or the tail suspension test. These data indicate that social disruption stress causes an increase in anxiety-like behaviors, but not depressive-like behaviors.
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Neuroinflammatory signaling is increased by RSD and is argued to facilitate vulnerability toward mood disorders.
“In addition to activating neuronal fear/anxiety circuitry, neuroinflammatory signaling is increased by RSD (Kinsey et al, 2007;Wohleb et al, 2012) that is argued to facilitate vulnerability toward mood disorders (Haroon et al, 2012).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Kinsey et al, 2007
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The inflammatory response to social defeat is increased in older mice
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Psychological stress and cancer
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Influenza Virus-Specific Immunological Memory Is Enhanced by Repeated Social Defeat
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- Authors
- Kinsey, S. G., Bailey, M. T., Sheridan, J. F., Padgett, D. A., & Avitsur, R.
- Affiliations
- The Ohio State University (US)
- Academic College of Tel Aviv-Yafo (IL)
- Corresponding author
- Padgett, David A.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 21
- Issue
- 4
- Pages
- 458-466
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC1941837
- OpenAlex
- W2021700795
- Cited by
- 190
- References
- 47
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 19 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH46801-13, R01MH046801)
- National Institute of Dental and Craniofacial Research (T32DE014320)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social defeat, anxiety-like behavior, depression-like behavior, C57BL/6 mice, ICR mice, social stress, immune response, glucocorticoid resistance, hyperinflammation
- MeSH terms
- Aggression, Analysis of Variance, Animals, Anxiety, Depression, Dominance-Subordination, Male, Mice, Inbred C57BL, Social Behavior, Species Specificity, Spleen, Stress, Psychological, Mice
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