Cited by 190Stress Responses and CortisolTryptophan and brain disordersNeurotransmitter Receptor Influence on Behavior

Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice

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Kinsey, Steven G., Bailey, Michael T., Sheridan, John F., Padgett, David A., Avitsur, Ronit·2007·Brain, Behavior, and Immunity

Abstract

The experimental model, social disruption (SDR), is a model of social stress in which mice are repeatedly attacked and defeated in their home cage by an aggressive conspecific. In terms of the impact of this stressor on the immune response, SDR has been reported to cause hyperinflammation and glucocorticoid insensitivity. To this point however, the behavioral consequences of SDR have not been thoroughly characterized. Because social defeat has been reported to cause anxiety- and depressive-like behaviors, the current study was designed to assess whether SDR also causes anxiety- and depressive-like behaviors. Using the light/dark preference test and the open field test as tools to measure behaviors characteristic of anxiety, the data showed that C57BL/6 and CD-1 male mice subjected to SDR displayed increased anxiety-like behavior. The increase in anxiety-like behaviors persisted for at least 1 week after the cessation of the stressor. In contrast, depressive-like behaviors were not elicited by SDR as assessed by the forced swim test or the tail suspension test. These data indicate that social disruption stress causes an increase in anxiety-like behaviors, but not depressive-like behaviors.

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Crossref · 10.1016/j.bbi.2006.11.001

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  • Neuroinflammatory signaling is increased by RSD and is argued to facilitate vulnerability toward mood disorders.

    “In addition to activating neuronal fear/anxiety circuitry, neuroinflammatory signaling is increased by RSD (Kinsey et al, 2007;Wohleb et al, 2012) that is argued to facilitate vulnerability toward mood disorders (Haroon et al, 2012).”

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Research works printed but not linked: 1

  1. Hebert MA, Evenson AR, Lumley LA, Meyerhoff JL. Effects of acute social defeat on activity in the forced swim test: parametric studies in DBA/2 mice using a novel measurement device. Aggress Behav. 1998;24:257–269. [Google Scholar]

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Authors
Kinsey, S. G., Bailey, M. T., Sheridan, J. F., Padgett, D. A., & Avitsur, R.
Affiliations
  • The Ohio State University (US)
  • Academic College of Tel Aviv-Yafo (IL)
Corresponding author
Padgett, David A.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2007-05
Volume
21
Issue
4
Pages
458-466
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2021700795
Cited by
190
References
47
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 19 · 2014: 13 · 2013: 11 · 2012: 13
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01 MH46801-13, R01MH046801)
  • National Institute of Dental and Craniofacial Research (T32DE014320)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
social defeat, anxiety-like behavior, depression-like behavior, C57BL/6 mice, ICR mice, social stress, immune response, glucocorticoid resistance, hyperinflammation
MeSH terms
Aggression, Analysis of Variance, Animals, Anxiety, Depression, Dominance-Subordination, Male, Mice, Inbred C57BL, Social Behavior, Species Specificity, Spleen, Stress, Psychological, Mice

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