The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Terpenoids from the seeds of Artemisia annua
Abstract
Fourteen sesquiterpenes, three monoterpenes and one diterpene natural product have been isolated from the seeds of Artemisia annua. The possible biogenesis of some of these natural products are discussed by reference to recently reported experimental results for the autoxidation of dihydroartemisinic acid and other terpenoids from Artemisia annua.
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In the citing paper
“which have been isolated from both leaves [67] and seeds [9] of A. annua.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“The secondary and tertiary allylic hydroperoxides, α- and β-myrcene hydroperoxide (265 and 264), have been isolated from A. annua on more than one occasion [9,114]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“It has been suggested that reduction of the hydroperoxide in 414 would then result in the allylic alcohol group observed in the natural product 5α-hydroxy-eudesma-4(15),11-diene (413), as shown in Scheme 4 [9].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“The isolation of the eudesmane allylic hydroperoxide (414) from A. annua is significant, as its structure is suggestive of formation by spontaneous autoxidation of the hydrocarbon precursor selina-4,11-diene (422) [9].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“Similarly, the unusual carbon skeleton of 503 might also have arisen from an amorphane precursor, in which the A ring has been contracted from six to five atoms, as a result of carbon-carbon bond migration of C-3 from C-4 to C-5 [9].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“Both phytol (550) itself and an authentic sample of phytene-1,2-diol (552) were subsequently obtained as natural products from the seeds of A. annua [9].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“The structure of the diterpene phytene-1-ol-2-hydroperoxide (553) [9,260] was wrongly assigned as phytene-1,2-diol (552), when it was first described as a natural product from A. annua [261].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
In the citing paper
“The structure of 3α,15-dihydroxycedrane (534) from A. annua has been rigorously determined both by 2D-NMR and by synthesis from (+)-β-cedrene [9].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [9]
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“Signal assignment followed the strategy applied previously for the structural characterisation of plant metabolites, and the resulting 1 H and 13 C assignments were established by direct comparison with the published data for cedrane-type sesquiterpenoids reported by Brown et al. 24 (–)- epi -cedrol : Colourless needl…”
Metadata
- Authors
- Brown, G. D., Liang, G.-Y., & Sy, L.-K.
- Affiliations
- University Grants Committee (HK)
- Corresponding author
- Brown, Geoffrey D.
- ORCID
- Brown, Geoffrey D.
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 64
- Issue
- 1
- Pages
- 303-323
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2014117923
- Cited by
- 153
- References
- 65
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 15 · 2020: 4 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 12 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 16
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- University of Hong Kong
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Artemisia annua, seeds, sesquiterpenes, monoterpenes, diterpenoids, autoxidation, dihydroartemisinic acid, natural product isolation
- MeSH terms
- Models, Molecular, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Seeds, Stereoisomerism, Terpenes, Artemisia annua, Artemisinins
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