Studies on the Constituents of Artemisia annua Part II*

You-you, Tu; Mu-yun, Ni; Yu-rong, Zhong; Lan-na, Li; Shu-lian, Cui; Mu-qun, Zhang; Xiu-zhen, Wang; Zheng, Ji; Xiao-tian, Liang

doi:10.1055/s-2007-971424

Cited by 125Sesquiterpenes and Asteraceae StudiesPhytochemistry and Biological ActivitiesPlant chemical constituents analysis

Studies on the Constituents of Artemisia annua Part II*

Open access

You-you, Tu, Mu-yun, Ni, Yu-rong, Zhong, Lan-na, Li, Shu-lian, Cui, Mu-qun, Zhang, Xiu-zhen, Wang, Zheng, Ji +1 more·1982·Planta Medica

DOI 10.1055/s-2007-971424

Open this paper in CoChat — free account Open PDF

Abstract

The present paper is a continuation of our study on the Chinese traditional herb Artemisia annua L. [1-5], describing several additional constituents: quinghaosu IV and V (V, VII), quinghao acid (VIII) [6], chrysosplenol (VIa) [7] and a paraffinic alcohol; V, VII and VIII are compounds with unreported structures. Key Word Index Artemisia annua L. - Compositae - Qinghaosu - Qinghaosu I-V - Qinghao acid - Flavones - Alkanol - Scopoletin - Essential oil

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1055/s-2007-971424

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Artemisinic acid, arteannuin B, and artemisinin were amongst the first sesquiterpenes to be reported from A. annua.
“and were amongst the first sesquiterpenes to be reported from A. annua.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [147]
Artemisinic acid, arteannuin B, and artemisinin are the most abundant representatives of the amorphane/cadinane class of natural products from A. annua.
“Artemisinic acid (473) [105,147,148], arteannuin B (462) [105,147,149] and artemisinin (495) [105,147,150] are the most abundant representatives of this class of natural products”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [147]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The publisher hasn’t deposited this paper’s reference list.

Research works printed but not linked: 10

I) Cooperative research group on the structure of qinghaosu: Kexue Toiigbao 22, 142 (1977).
Liu,J.M.,M.Y.Ni,J.F.Fan, Y. Y. Tu, Z. H. Wu. Y. L. Wu and W. S. Zhou: Acta Chimica Sinica 37, 129 (1979).
Journal reporter: J. New Med. /,10(1979).
Cooperative research group on qinghaosu: Yaoxue Tongbao /4,49 (1979).
Tu, Y. Y., M. Y. Ni. Y. R. Zhong. L. N. Li, S. L. Cui, M. 0. Zhang, X. Z. Wang and X. T. Liang: Acta Pharm. Sinica /6, 366 (1981).
Ghisalberti, F. L., P. R. Jeffe- ries and C. I. Stacey: Aust. J. Chem. 20(5), 1049 (1967).
Jeremic, D., A. Jokic, A. Beh- bud and M. Stefanovic: Tetrahe- dron Letters 32,3039(1973).
Vlahav, R., M. Hoiub and V. Herout: Coil. Czech. Chem. Comm. 32, 822 (1967).
Liang. X. T.: NMR, Analysis and Appiications of High Resoiu- tion Proton Spectra (in Chinese), p. 268, Science Press (1976).
Ryhage, R. and E. Stenha- gen: J. Lipid Research 1, 361 (1960).

Sorted by citations

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
Tu, Y. (2011) · Nature Medicine · doi:10.1038/nm.2471 · Cited by 1,397 · see citing works
“However, the prevailing environment in China at the time restrained the publication of any papers concerning qinghaosu, with the exception of several published in Chines”
Background
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Current status of artemisinin and its derivatives as antimalarial drugs
Dhingra, V., Rao, K. V., & Narasu, M. L. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00356-2 · Cited by 241 · see citing works
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works
Artemisinin, a Constituent of Annual Wormwood (Artemisia annua), is a Selective Phytotoxin
Duke, S. O., Vaughn, K. C., Croom, E. M., & ElSohly, H. N. (1987) · Weed Science · doi:10.1017/s0043174500060458 · Cited by 186 · see citing works
Lactones: Classification, synthesis, biological activities, and industrial applications
Sartori, S. K., Diaz, M. A. N., & Diaz‐Muñoz, G. (2021) · Tetrahedron · doi:10.1016/j.tet.2021.132001 · Cited by 182 · see citing works
Unified Mechanistic Framework for the Fe(II)-Induced Cleavage of Qinghaosu and Derivatives/Analogues. The First Spin-Trapping Evidence for the Previously Postulated Secondary C-4 Radical
Wu, W., Wu, Y., Wu, Y., et al. (1998) · Journal of the American Chemical Society · doi:10.1021/ja973080o · Cited by 175 · see citing works
Artemisia annua L.
Tang, W., & Eisenbrand, G. (1992) · Springer eBooks · doi:10.1007/978-3-642-73739-8_22 · Cited by 158 · see citing works
Terpenoids from the seeds of Artemisia annua
Brown, G. D., Liang, G.-Y., & Sy, L.-K. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00294-2 · Cited by 153 · see citing works
Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation
Frenzel, C., & Teschke, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050588 · Cited by 140 · see citing works
In vivo transformations of artemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.062 · Cited by 100 · see citing works
Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs
Teschke, R., Larrey, D. G., Melchart, D., & Danan, G. (2016) · Medicines · doi:10.3390/medicines3030018 · Cited by 95 · see citing works
Naturally occurring cadinenes
Bordoloi, M., Shukla, V., Nath, S. C., & Sharma, R. P. (1989) · Phytochemistry · doi:10.1016/s0031-9422(00)97915-9 · Cited by 88 · see citing works
State of the art of the production of the antimalarial compound artemisinin in plants
Geldre, E. V., Vergauwe, A., & den Eeckhout, E. V. (1997) · Plant Molecular Biology · doi:10.1023/a:1005716600612 · Cited by 84 · see citing works
A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua
Ma, D.-M., Wang, Z., Wang, L., Alejos-Gonzales, F., Sun, M.-A., & Xie, D.-Y. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.07.004 · Cited by 83 · see citing works
Analysis of artemisinin and related sesquiterpenoids from artemisia annua L. by combined gas chromatography/mass spectrometry
Woerdenbag, H. J., Pras, N., Bos, R., Visser, J. F., Hendriks, H., & Malingré, T. M. (1991) · Phytochemical Analysis · doi:10.1002/pca.2800020507 · Cited by 78 · see citing works
Direct analysis of artemisinin from Artemisia annua L. using high-performance liquid chromatography with evaporative light scattering detector, and gas chromatography with flame ionization detector
Peng, C. A., Ferreira, J., & Wood, A. J. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.043 · Cited by 74 · see citing works
Artemisia annua L.: a source of novel antimalarial drugs
Woerdenbag, H. J., Lugt, C., & Pras, N. (1990) · Pharmacy World & Science · doi:10.1007/bf01980041 · Cited by 73 · see citing works
Discovery of Artemisinin (Qinghaosu)
Liao, F. (2009) · Molecules · doi:10.3390/molecules14125362 · Cited by 71 · see citing works
Simple high-performance liquid chromatographic method with electrochemical detection for the simultaneous determination of artesunate and dihydroartemisinin in biological fluids
Na‐Bangchang, K., Congpuong, K., Hung, L. N., et al. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(97)00667-1 · Cited by 69 · see citing works
Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua
Sangwan, R. S., Agarwal, K., Luthra, R., Thakur, R. S., & Sangwan, N. S. (1993) · Phytochemistry · doi:10.1016/0031-9422(91)80019-w · Cited by 68 · see citing works
A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides
Sy, L., Brown, G. D., & Haynes, R. K. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00148-3 · Cited by 66 · see citing works
Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare
Zhang, R., Gao, X., Bai, H., & Ning, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00538 · Cited by 68 · see citing works
“Youyou Tu, the Nobel Prize winner, has also focused on TCM research and research on the combination of western medicine and TCM for many years (Tu et al., 1981; Tu et al., 1982) .”
Background
Identifying citation patterns of scientific breakthroughs: A perspective of dynamic citation process
Min, C., Bu, Y., Wu, D., et al. (2020) · Information Processing & Management · doi:10.1016/j.ipm.2020.102428 · Cited by 65 · see citing works
Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives
Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9480-2 · Cited by 63 · see citing works
Three sesquiterpenes from Artemisia annua
Sy, L., & Brown, G. D. (1998) · Phytochemistry · doi:10.1016/s0031-9422(97)01047-9 · Cited by 62 · see citing works
Laboratory selection of Artemisia annua L. for high artemisinin yielding types
Pras, N., Visser, J. F., Batterman, S., Woerdenbag, H. J., Malingré, T. M., & Lugt, C. (1991) · Phytochemical Analysis · doi:10.1002/pca.2800020208 · Cited by 61 · see citing works
Dimeric Cadinane Sesquiterpenoid Derivatives from Artemisia annua
Qin, D.-P., Pan, D., Xiao, W. L., Li, H., Yang, B., Yao, X., Dai, Y., Yu, Y., & Yao, X. (2018) · Organic Letters · doi:10.1021/acs.orglett.7b03796 · Cited by 55 · see citing works
Immunoquantitative analysis of artemisinin from Artemisia annua using polyclonal antibodies
Ferreira, J., & Janick, J. (1996) · Phytochemistry · doi:10.1016/0031-9422(95)00542-0 · Cited by 54 · see citing works
Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity
Kapkoti, D. S., Singh, S., Luqman, S., & Bhakuni, R. S. (2018) · New Journal of Chemistry · doi:10.1039/c7nj04271j · Cited by 51 · see citing works
Artemisiaannua: Botany, Horticulture, Pharmacology
Ferreira, J., Simon, J. E., & Janick, J. (1996) · Horticultural reviews · doi:10.1002/9780470650622.ch6 · Cited by 50 · see citing works
Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine
A, W. C. V. V., van Huijsduijnen, R. H., & Wells, T. N. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520952112 · Cited by 47 · see citing works
Gmelinosides A−L, Twelve Acylated Iridoid Glycosides from Gmelina arborea
Hosny, M., & Rosazza, J. P. N. (1998) · Journal of Natural Products · doi:10.1021/np970447u · Cited by 46 · see citing works
On the possible role of qinghao acid in the biosynthesis of artemisinin
El-Feraly, F. S., Al-Meshal, I. A., Al-Yahya, M. A., & Hifnawy, M. S. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)83739-5 · Cited by 41 · see citing works
Cadinanes from Artemisia annua that may be intermediates in the biosynthesis of artemisinin
Brown, G. D. (1994) · Phytochemistry · doi:10.1016/s0031-9422(00)89788-5 · Cited by 41 · see citing works
Biosynthesis of artemisinic acid in Artemisia annua
Akhila, A., Rani, K., & Thakur, R. S. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)83020-2 · Cited by 41 · see citing works
Artemisinin susceptibility in the malaria parasitePlasmodium falciparum: propellers, adaptor proteins and the need for cellular healing
Sutherland, C. J., Henrici, R. C., & Artavanis‐Tsakonas, K. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa056 · Cited by 41 · see citing works
A concise synthesis of 12-(3'-hydroxy-n-propyl)-deoxoartemisinin
Jung, M., Yu, D., Bustos, D. A., ElSohly, H. N., & McChesney, J. D. (1991) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)81060-x · Cited by 39 · see citing works
Ferrous ion induced cleavage of the peroxy bond in qinghaosu and its derivatives and the DNA damage associated with this process
Wu, W., Yao, Z., Wu, Y., Jiang, K., Wang, Y., Cehn, H.-B., Shan, F., & Li, Y. (1996) · Chemical Communications · doi:10.1039/cc9960002213 · Cited by 39 · see citing works
Process modelling and simulation for continuous pharmaceutical manufacturing of artemisinin
Jolliffe, H. G., & Gerogiorgis, D. I. (2016) · Process Safety and Environmental Protection · doi:10.1016/j.cherd.2016.02.017 · Cited by 37 · see citing works
Chemical constituents from Artemisia argyi and their chemotaxonomic significance
Zhang, L., Lv, J.-L., Chen, H., et al. (2013) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2013.06.010 · Cited by 36 · see citing works
Eudesmane sesquiterpenes from Artemisia eriopoda
Hu, J., Bai, S., & Jia, Z. (1996) · Phytochemistry · doi:10.1016/0031-9422(96)00325-1 · Cited by 36 · see citing works
Synergistic Inhibition of Angiogenesis by Artesunate and CaptoprilIn VitroandIn Vivo
Krusche, B., Arend, J., & Efferth, T. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/454783 · Cited by 34 · see citing works
A comparison of gas chromatography and high performance liquid chromatography for artemisinin analyses
Ferreira, J., Charles, D. J., Wood, K. V., Janick, J., & Simon, J. E. (1994) · Phytochemical Analysis · doi:10.1002/pca.2800050306 · Cited by 34 · see citing works
Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua
Breuer, E., & Efferth, T. (2014) · Natural Products and Bioprospecting · doi:10.1007/s13659-014-0013-7 · Cited by 33 · see citing works
Scientific influence is not always visible: The phenomenon of under-cited influential publications
Hu, X., & Rousseau, R. (2016) · Journal of Informetrics · doi:10.1016/j.joi.2016.10.002 · Cited by 31 · see citing works
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31 · see citing works
“A recombinant ADH1 protein was shown to catalyze an NAD(P)-dependent oxidation converting dihydroartemisinic aldehyde to dihydroartemisinic acid ( Teoh et al. 2009 ).”
BackgroundInfluential
Strong larvicidal potential of Artemisia annua leaf extract against malaria (Anopheles stephensi Liston) and dengue (Aedes aegypti L.) vectors and bioassay-driven isolation of the marker compounds
Sharma, G., Kapoor, H., Chopra, M., Kumar, K., & Agrawal, V. (2013) · Parasitology Research · doi:10.1007/s00436-013-3644-4 · Cited by 30 · see citing works
Affordable and sensitive determination of artemisinin in Artemisia annua L. by gas chromatography with electron-capture detection
Liu, S., Tian, N., Liu, Z., Huang, J., Li, J., & Ferreira, J. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.089 · Cited by 29 · see citing works
Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Tian, H., Li, X. P., Zhao, J., et al. (2021) · Phytochemistry · doi:10.1016/j.phytochem.2021.112682 · Cited by 27 · see citing works
Structurally diverse sesquiterpenoids from the aerial parts of Artemisia annua (Qinghao) and their striking systemically anti-inflammatory activities
Qin, D.-P., Li, H., Pang, Q., Huang, Y., Pan, D., Su, Z.-Z., Yao, X., Yao, X., Xiao, W. L., & Yu, Y. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104221 · Cited by 26 · see citing works
Expanding the Therapeutic Spectrum of Artemisinin: Activity Against Infectious Diseases Beyond Malaria and Novel Pharmaceutical Developments
Efferth, T., Romero, M. R., Bilia, A. R., Osman, A. G., ElSohly, M. A., Wink, M., Bauer, R., Khan, I. A., Bergonzi, M. C., & Marı́n, J. J. G. (2016) · World Journal of Traditional Chinese Medicine · doi:10.15806/j.issn.2311-8571.2016.0002 · Cited by 26 · see citing works
Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 24 · see citing works
The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu.
Tu, Y. (2004) · PubMed · Cited by 25 · see citing works
DNA Barcode for Identifying Folium Artemisiae Argyi from Counterfeits
Quanxi, M., Chen, X., Xiang, L., et al. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00336 · Cited by 24 · see citing works
Arteannuin-C, a sesquiterpene lactone from Artemisia annua
Misra, L. N. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)83762-0 · Cited by 24 · see citing works
Microbiological transformations of artemisinic acid
Elmarakby, S. A., El‐Feraly, F. S., ElSohly, H. N., et al. (1988) · Phytochemistry · doi:10.1016/0031-9422(88)80006-2 · Cited by 23 · see citing works
Artemisinin: An Endoperoxidic Antimalarial from Artemisia annua L.
Ziffer, H., Highet, R. J., & Klayman, D. L. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6527-0_2 · Cited by 23 · see citing works
Endophytes in Artemisia annua L.: new potential regulators for plant growth and artemisinin biosynthesis
Zheng, L. P., Li, X. P., Zhou, L. L., & Wang, J. (2021) · Plant Growth Regulation · doi:10.1007/s10725-021-00751-3 · Cited by 21 · see citing works
Annulide, a sesquiterpene lactone from Artemisia annua
Brown, G. D. (1993) · Phytochemistry · doi:10.1016/s0031-9422(00)95001-5 · Cited by 22 · see citing works
Bisnor-cadinanes from Artemisia annua and definitive 13C NMR assignments of β-arteether
Misra, L. N., Ahmad, A., Thakur, R. S., & Jakupovic, J. (1993) · Phytochemistry · doi:10.1016/0031-9422(93)85111-4 · Cited by 21 · see citing works
A pure line derived from a self-compatible Chrysanthemum seticuspe mutant as a model strain in the genus Chrysanthemum
Nakano, M., Taniguchi, K., Masuda, Y., et al. (2019) · Plant Science · doi:10.1016/j.plantsci.2019.110174 · Cited by 21 · see citing works
How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review
Moss, S., Mańko, E., Krishna, S., et al. (2022) · Malaria Journal · doi:10.1186/s12936-022-04181-y · Cited by 21 · see citing works
Sesquiterpenic acids from Leucanthemopsis pulverulenta
Teresa, J. D. P., Valle, M., González, M., et al. (1984) · Tetrahedron · doi:10.1016/s0040-4020(01)88464-7 · Cited by 21 · see citing works
A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Li, Y., & Wu, Y. (2010) · Frontiers of Chemistry in China · doi:10.1007/s11458-010-0214-5 · Cited by 20 · see citing works
Characterization of the hot and cold medicinal properties of traditional Chinese herbs by spontaneous photon emission ratio of mice
Zhou, B., Li, T., Yang, M., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112108 · Cited by 19 · see citing works
Herbicide Inputs for a New Agronomic Crop, Annual Wormwood (Artemisia annua)
Bryson, C. T., & Croom, E. M. (1991) · Weed Technology · doi:10.1017/s0890037x00033376 · Cited by 18 · see citing works
Partial purification of proteins involved in the bioconversion of arteannuin B to artemisinin
Dhingra, V (2000) · Bioresource Technology · doi:10.1016/s0960-8524(99)00152-2 · Cited by 17 · see citing works
Autoxidation of 4-amorphen-11-ol and the biogenesis of nor- and seco-amorphane sesquiterpenes from fabiana imbricata
Ngo, K., & Brown, G. D. (1999) · Tetrahedron · doi:10.1016/s0040-4020(99)00986-2 · Cited by 17 · see citing works
IN VIVO ANTIMALARIAL ACTIVITIES OF FRACTIONATED EXTRACTS OF Asparagus africanus IN MICE INFECTED WITH Plasmodium Berghei
Debebe, Y., Mekonnen, Y., & Debella, A. (2012) · Cited by 16 · see citing works
Rapid characterization of artemether and its in vitro metabolites on incubation with bovine hemoglobin, rat blood and dog blood by capillary gas chromatography–chemical ionization mass spectrometry
Blum, W., Pfaar, U., & Kühnöl, J. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00113-3 · Cited by 16 · see citing works
Studies on the biosynthesis of arteannuin. IV. The biosynthesis of arteanniuin and arteannuin B by the leaf homogenate of Artemisia annua L.
Wang, Y., Xia, Z., Feng-Yi, Z., Wu, Y., Huang, J., & Zhi-zhong, W. (1993) · Chinese Journal of Chemistry · doi:10.1002/cjoc.19930110512 · Cited by 15 · see citing works
In vitro and in vivo anti-eczema effect of Artemisia annua aqueous extract and its component profiling
Zhao, Y., Le, Z., Yang, L., Chen, M., Sun, P., Ma, Y., Zhang, D., Ya, Z., & Jia, H. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117065 · Cited by 13 · see citing works
Novel biotransformation processes of artemisinic acid to their hydroxylated derivatives 3β-hydroxyartemisinic acid and 3β, 15-dihydroxyartemisinic by fungus Trichothecium roseum CIMAPN1and their biological evaluation
Gaur, R., Tiwari, S., Jakhmola, A., Thakur, J. P., Verma, R. K., Pandey, R., & Bhakuni, R. S. (2014) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2014.04.008 · Cited by 13 · see citing works
Three diterpenes with a secolabdane skeleton from Clutia abyssinica
Waigh, R. D., Zerihun, B., & Melvin, R. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)87109-8 · Cited by 12 · see citing works
Elucidation of the natural artemisinin decomposition route upon iron interaction: a fine electronic redistribution promotes reactivity
Nosoongnoen, W., Pratuangdejkul, J., Sathirakul, K., Jacob, A., Conti, M., Loric, S., Launay, J., & Manivet, P. (2008) · Physical Chemistry Chemical Physics · doi:10.1039/b804516j · Cited by 11 · see citing works
Elucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models
Wang, T., Liang, L., Zhao, C.-L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89035-4 · Cited by 10 · see citing works
Tradition to Pathogenesis: A Novel Hypothesis for Elucidating the Pathogenesis of Diseases Based on the Traditional Use of Medicinal Plants
Kuchta, K., & Cameron, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.705077 · Cited by 10 · see citing works
Two new sesquiterpenes from Artemisia annua L.
Takenaka, Y., Seki, S., Nishi, T., & Tanahashi, T. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01436-3 · Cited by 9 · see citing works
Semi-synthesis of deoxyartemisinin
Bhattacharya, A. K., Pathak, A. K., & Sharma, R. P. (2007) · Mendeleev Communications · doi:10.1016/j.mencom.2007.01.011 · Cited by 9 · see citing works
Antimalarial and cytotoxic properties of Chukrasia tabularis A. Juss and Turraea vogelii Hook F. Ex. Benth
Ogbole, O. O., Saka, Y. A., Fasinu, P. S., et al. (2016) · Parasitology Research · doi:10.1007/s00436-016-4906-8 · Cited by 8 · see citing works
Recent progress in the synthesis of antimalarial indoloquinoline natural products and analogues
Sydnes, M. O. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817903-1.00002-4 · Cited by 8 · see citing works
In vivo transformations of dihydro-epi-deoxyarteannuin B in Artemisia annua plants
Brown, G. D., & Sy, L. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.016 · Cited by 8 · see citing works
Simple, Fast, and Sensitive detection of artemisinin in human serum and Artemisia annua using microsensor array coupled with electrochemiluminescent imaging technique
Tang, X.-C., Xiao, Y., Li, P., et al. (2018) · Talanta · doi:10.1016/j.talanta.2018.12.016 · Cited by 7 · see citing works
Publication process involving the discovery of artemisinin (qinghaosu) before 1985
Wang, M. (2016) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2016.04.009 · Cited by 6 · see citing works
Recent Trends on Production Sources, Biosynthesis Pathways and Antiviral Efficacies of Artemisinin: A Candidate Phytomedicine against SARS-CoV-2
Hussain, A. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230327082051 · Cited by 6 · see citing works
Artemisinin the Nobel Molecule
Weathers, P. J., Cambra, H. M., Desrosiers, M. R., Rassias, D., & Towler, M. J. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63931-8.00005-9 · Cited by 6 · see citing works
Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana
Bhat, K. A., Naseer, S., Gani, I., et al. (2021) · ChemistrySelect · doi:10.1002/slct.202003944 · Cited by 6 · see citing works
Proton and carbon‐13 NMR and conformation in solution of some amorphanes (quinghaosu derivatives)
Marsaioli, A. J., Fujiwara, F. Y., Foglio, M. A., Sharapin, N., & Zhang, J. (1994) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1260321004 · Cited by 6 · see citing works
A secoamorphane tri-ether from Cupressus macnabiana foliage
Cool, L. G., & Jiang, K. (1995) · Phytochemistry · doi:10.1016/0031-9422(95)00405-v · Cited by 6 · see citing works
Sesquiterpenoids
Connolly, J. D., & Hill, R. A. (1991) · Springer eBooks · doi:10.1007/978-1-4899-4513-6_3 · Cited by 6 · see citing works
Biotransformation of artemisinic acid by the fungus Trichothecium roseum and anti-candidal activity of its metabolites
Singh, P., Kapkoti, D. S., Singh, N., Tewari, R., Saikia, D., Rout, P. K., Pandey, R., & Bhakuni, R. S. (2019) · Biocatalysis and Biotransformation · doi:10.1080/10242422.2018.1552265 · Cited by 5 · see citing works
“All the protons and carbons of the compound 4 were assigned by the analysis of its 1H, 13C, DEPT and HMBC, NMR spectra and compared with spectral data reported for artemisinic acid (You-You et al. 1982; Jung et al. 1986).”
Background
Artemisinin is highly soluble in polyethylene Glycol 4000 and such solution has multiple biological effects
Dai, F., Bao, Y. J., Li, Z., Chen, S., Gao, L.-Z., Liu, Z.-L., Cheng, L., Peng, Y., & Tong, X. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5190 · Cited by 5 · see citing works
Artemisia annua (Quing-Hao): In Vitro Culture and the Production of Artemisinin
Paniego, N. B., Maligne, A. E., & Giulietti, A. M. (1993) · Biotechnology in agriculture and forestry · doi:10.1007/978-3-642-58062-8_5 · Cited by 5 · see citing works
Evaluation of Achyranthes aspera shoot extract as an alternative therapy for malaria
Mankilik, M. M., Longdet, I. Y., & Luka, C. D. (2021) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-021-00211-4 · Cited by 4 · see citing works
Modification of the sesquiterpene lactone arteannuin B and antimicrobial activities of the products obtained
Abduazimov, B. K., Zoirova, K. T., Sham’yanov, I. D., et al. (1997) · Chemistry of Natural Compounds · doi:10.1007/bf02254803 · Cited by 4 · see citing works
Use of Sargassum fusiforme Extract and its Bioactive Molecules to inhibit HIV Infection: Bridging Two Paradigms between Eastern and Western Medicine
Guo, H., Liu, Y., Paskaleva, E. E., et al. (2014) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(14)60041-1 · Cited by 4 · see citing works
“…antimalarial drug artemisinin that was extracted from Artemisia annua L. by cold water (Chen et al, 2012; Tu et al, 1981; Klayman, 1985; Tu, 2011; You-You et al, 1982), and FDA approved arsenic trioxide (trisenox) that was traditionally used to treat acute promyelocytic leukemia (APL) (Kwong and…”
Method
Mechanistic Insights into the Nonenzymatic Biosynthesis of Artemisinin and Related Natural Products: A Quantum Chemical Study
Yan, M., Ding, X., Zhao, L., Lü, X., He, H., Fan, S., & Yang, Z. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00034 · Cited by 3 · see citing works
A critical review on rubriflordilactones A, B, and C: occurrence, structural diversity, bioactivities, and synthesis
Bansal, D., Sivaganesan, P., Elanchezhian, C., et al. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob01614b · Cited by 3 · see citing works
Plants with antimalarial properties: A systematic review of the current clinical evidence
Aracil, A., & Green, J. (2019) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2019.04.005 · Cited by 3 · see citing works

Ancient Chinese Methods Are Remarkably Effective for the Preparation of Artemisinin-Rich Extracts of Qing Hao with Potent Antimalarial Activity
Wright, C. W., Linley, P. A., Brun, R., Wittlin, S., & Hsü, E. (2010) · Molecules · doi:10.3390/molecules15020804 · Cited by 77 · see citing works
Evaluation of stability of constituents of herbal drug preparations from Artemisia annua L.
Timóteo, P., Wessels, C., Righeschi, C., et al. (2010) · Planta Medica · doi:10.1055/s-0030-1264749 · Cited by 1 · see citing works
Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria
Mueller, M. S., Runyambo, N., Wagner, I., Borrmann, S., Dietz, K., & Heide, L. E. (2004) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2003.09.001 · Cited by 146 · see citing works
A review on pharmacological properties of Artemisia annua
Verma, M., Sharma, S., & Kumar, S. (2020) · Journal of Pharmacognosy and Phytochemistry · Cited by 2 · see citing works
Influence of harvesting stage on herb, essential oil and artemisinin yields in the antimalarial herb, Artemisia annua L.
Abirami, K., Rana, V. S., Baskaran, V., & Das, M. (2018) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/0975-6892.2018.00006.0

Authors: You-you, T., Mu-yun, N., Yu-rong, Z., Lan-na, L., Shu-lian, C., Mu-qun, Z., Xiu-zhen, W., Zheng, J., & Xiao-tian, L.
Affiliations: Institute of Chinese Materia Medica (CN)
ORCID: Zheng, Ji
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 1982-03
Volume: 44
Issue: 03
Pages: 143-145
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2007-971424
OpenAlex: W1971899040
Cited by: 125
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
FWCI: 0.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Keywords: Artemisia annua, scopoletin, flavones, essential oils, natural compounds, traditional Chinese medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Studies on the Constituents of Artemisia annua Part II*

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks