Cited by 129Sesquiterpenes and Asteraceae StudiesPlant biochemistry and biosynthesisPhytochemical compounds biological activities

Isolation and Identification of Dihydroartemisinic Acid from Artemisia annua and Its Possible Role in the Biosynthesis of Artemisinin

Wallaart, T. Eelco, van Uden, Wim, Lubberink, Heidi G. M., Woerdenbag, Herman J., Pras, Niesko, Quax, Wim J.·1999·Journal of Natural Products

Abstract

Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by 1H and 13C NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.

Integrity signals

Registry

Crossref · 10.1021/np980370p

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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Authors
Wallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., & Quax, W. J.
Affiliations
  • University of Groningen (NL)
  • Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies, University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands
Venue
Journal of Natural Products
Published
1999-02-04
Volume
62
Issue
3
Pages
430-433
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
OpenAlex
W2132259321
Cited by
129
References
13
Citations by year
2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
Keywords
dihydroartemisinic acid, artemisinin, Artemisia annua, artemisinin biosynthesis, natural product isolation, structure elucidation, sesquiterpene lactones

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