The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Improvement in Mood, Physical Symptoms, and Function With Nortriptyline for Depression in Patients With Chronic Obstructive Pulmonary Disease
Abstract
Although recent epidemiologic studies have established that patients with chronic medical illness and depressed mood are more disabled than euthymic patients, detailed data on the benefits and risks of antidepressant treatment in medically high-risk patients have been slow to accumulate. The authors have examined multiple outcome indicators in patients with disabling chronic obstructive pulmonary disease and comorbid depression. Thirty patients completed a 12-week, randomized controlled trial of nortriptyline. Nortriptyline was clearly superior to placebo for treatment of depression. Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible. Physiological measures reflecting pulmonary insufficiency were generally unaffected by treatment. These data provide impetus for renewed efforts to improve recognition and treatment of mood disorders in even severely disabled medical patients.
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In the citing paper
“Depression has been found to predict fatigue, shortness of breath, and disability in patients with heart disease or COPD, even after adjusting for severity of illness.52–56”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“Evidence for antidepressant therapy in COPD is limited, with only one small, randomized, placebo-controlled trial53 of treatment in patients with major depression having been published.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“This study found high efficacy for nortriptyline, a tricyclic antidepressant, in improving short-term outcomes for depression, anxiety, panic attacks, cognitive function, and overall disability.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
Citations
Cites
The Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619
The functioning and well-being of depressed patients. Results from the Medical Outcomes Study
Wells, K. B. (1989) · JAMA · doi:10.1001/jama.262.7.914 · Cited by 2,826
Functional Status and Well-being of Patients With Chronic Conditions
Stewart, A. L. (1989) · JAMA · doi:10.1001/jama.1989.03430070055030 · Cited by 2,309
The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study
Wells, K. B. (1989) · JAMA · doi:10.1001/jama.1989.03430070062031 · Cited by 2,130
Stewart, A. L. (1989) · JAMA · doi:10.1001/jama.262.7.907 · Cited by 2,095
Somatization: the concept and its clinical application
(1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.11.1358 · Cited by 1,079
Sheehan, D. V. (1984) · Medical Entomology and Zoology · Cited by 883
Twelve-minute walking test for assessing disability in chronic bronchitis.
McGavin, C. R., Gupta, S., & McHardy, G. J. R. (1976) · BMJ · doi:10.1136/bmj.1.6013.822 · Cited by 746
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey, J. R., Pearlson, G., Robinson, R. G., Rao, K. C. V. G., & Price, T. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90356-8 · Cited by 536
Somatic presentation of DSM-III psychiatric disorders in primary care
Bridges, K. W., & Goldberg, D. P. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90064-9 · Cited by 534
Research works printed but not linked: 1
- Lareau, 1986, Functional levels and dyspnea in patients with COPD (abstract), Am Rev Respir Dis, 133, A163
Cited by
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Depression and Diabetes: Impact of Depressive Symptoms on Adherence, Function, and Costs
Ciechanowski, P. S., Katon, W. J., & Russo, J. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3278 · Cited by 1,465
Katon, W. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00273-7 · Cited by 1,248
Katon, W., Lin, E. H. B., & Kroenke, K. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2006.11.005 · Cited by 965
“Chronic obstructive lung disease Three studies were found that examined the association of anxiety and depression with symptoms of COPD (N=479) [31–33]; one treatment study examined the impact of enhanced treatment of depression in patients with COPD on medical symptom burden and objective pulmonary function testing (…”
BackgroundInfluentialEpidemiology and treatment of depression in patients with chronic medical illness
J. Katon, W. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/wkaton · Cited by 820
Anxiety and Depression in COPD
Maurer, J., Rebbapragada, V., Borson, S., Goldstein, R., Kunik, M. E., Yohannes, A. M., & Hanania, N. A. (2008) · Chest · doi:10.1378/chest.08-0342 · Cited by 720
Metadata
- Authors
- Borson, S., McDonald, G. J., Gayle, T., Deffebach, M., Lakshminarayan, S., & VanTuinen, C.
- Affiliations
- University of Washington (US)
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 33
- Issue
- 2
- Pages
- 190-201
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2040089352
- Cited by
- 277
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- nortriptyline, depression, chronic obstructive pulmonary disease, antidepressant treatment, comorbid depression, mood improvement, somatic symptoms, functional capacity, anxiety, pulmonary insufficiency, placebo effect, severely disabled patients
- MeSH terms
- Activities of Daily Living, Affect, Attitude to Health, Chronic Disease, Depressive Disorder, Dyspnea, Female, Humans, Lung Diseases, Obstructive, Male, Middle Aged, Nortriptyline, Patient Compliance, Placebos, Prednisone, Psychiatric Status Rating Scales
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