The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Improvement in Mood, Physical Symptoms, and Function With Nortriptyline for Depression in Patients With Chronic Obstructive Pulmonary Disease
Abstract
Although recent epidemiologic studies have established that patients with chronic medical illness and depressed mood are more disabled than euthymic patients, detailed data on the benefits and risks of antidepressant treatment in medically high-risk patients have been slow to accumulate. The authors have examined multiple outcome indicators in patients with disabling chronic obstructive pulmonary disease and comorbid depression. Thirty patients completed a 12-week, randomized controlled trial of nortriptyline. Nortriptyline was clearly superior to placebo for treatment of depression. Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible. Physiological measures reflecting pulmonary insufficiency were generally unaffected by treatment. These data provide impetus for renewed efforts to improve recognition and treatment of mood disorders in even severely disabled medical patients.
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“Depression has been found to predict fatigue, shortness of breath, and disability in patients with heart disease or COPD, even after adjusting for severity of illness.52–56”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“Evidence for antidepressant therapy in COPD is limited, with only one small, randomized, placebo-controlled trial53 of treatment in patients with major depression having been published.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“This study found high efficacy for nortriptyline, a tricyclic antidepressant, in improving short-term outcomes for depression, anxiety, panic attacks, cognitive function, and overall disability.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
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“82 Treatment of depression can have beneficial effects on many aspects of living with COPD, including a positive effect on dyspnea 83 and appears to have more beneficial effects on dypnea than the use of anxiolytics.”
Research advances in geriatric depression
Alexopoulos, G. S., & KELLY, R. E. (2009) · World Psychiatry · doi:10.1002/j.2051-5545.2009.tb00234.x · Cited by 95
“In a study of depressed patients with COPD, physical symptoms, function, and mood improved after treatment with antidepressant medication (146).”
BackgroundGiardino, N. D., Curtis, J. L., Andrei, A., Fan, V. S., Benditt, J. O., Lyubkin, M., Naunheim, K. S., Criner, G. J., Make, B. J., Wise, R. A., et al. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-29 · Cited by 96
“And, while there are no published large randomized controlled studies of treatments for anxiety disorders in patients with COPD, number of studies report decreased anxiety symptoms in COPD with antidepressant therapy [56-59], cognitive-behavioral therapy [60,61], or exercise therapy, including pulmonary rehabilitation…”
BackgroundDepression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD
Al-shair, K., Dockry, R., Mallia-Milanes, B., Kolsum, U., Singh, D., & Vestbo, J. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2008.11.021 · Cited by 88
Taylor, D. M., Meader, N., Bird, V., Pilling, S., Creed, F. H., & Goldberg, D. P. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.077610 · Cited by 84
Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ
Mercado, N., To, Y., Ito, K., & Barnes, P. J. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.175950 · Cited by 82
The Role of Medical Comorbidity in Outcome of Major Depression in Primary Care: The PROSPECT Study
Bogner, H. R., Cary, M. S., BRUCE, M. L., Reynolds, C. F., Mulsant, B. H., Have, T. T., & Alexopoulos, G. S. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.10.861 · Cited by 83
Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?
Pelgrim, C. E., Peterson, J. D., Gosker, H. R., Schols, A. M. W. J., van Helvoort, A., Garssen, J., Folkerts, G., & Kraneveld, A. D. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.10.001 · Cited by 85
End of life care in chronic obstructive pulmonary disease: in search of a good death
Booth, S. (2008) · International Journal of COPD · doi:10.2147/copd.s698 · Cited by 78
Caring for the Older Person With Chronic Obstructive Pulmonary Disease
Fried, T. R., Fragoso, C. A. V., & Rabow, M. W. (2012) · JAMA · doi:10.1001/jama.2012.12422 · Cited by 79
“This study showed the superiority of nortriptyline over placebo for treatment of depression, anxiety, and panic attacks in patients with COPD.63 There is preliminary evidence that cognitive behavioral therapy may improve depression and anxiety.64,65 Additionally, several studies have demonstrated the utility of pulmon…”
InfluentialUse of Health Services by Hospitalized Medically Ill Depressed Elderly Patients
Koenig, H. G., & Kuchibhatla, M. N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.871 · Cited by 77
“Studies of medically ill older patients have now demonstrated that treatment with either antidepressant medication (particularly when guided by psychiatric consultation) (26, 27) or psychotherapy (including patients who are persistently disabled) (28, 29) may reduce both depressive symptoms and their negative effects…”
BackgroundCoping and marital support as correlates of tinnitus disability
Sullivan, M. D., Katon, W. J., Russo, J. E., Dobie, R. A., & Sakai, C. S. (1994) · General Hospital Psychiatry · doi:10.1016/0163-8343(94)90005-1 · Cited by 76
Lareau, S. C., Breslin, E. H., & Meek, P. (1996) · Heart & Lung · doi:10.1016/s0147-9563(96)80032-x · Cited by 73
Functional performance in people with chronic obstructive pulmonary disease
Leidy, N. K. (1995) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.1995.tb00809.x · Cited by 73
Coventry, P. A. (2009) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3283218318 · Cited by 75
Effects of medical and psychological treatment of depression in patients with COPD – A review
Fritzsche, A., Clamor, A., & von Leupoldt, A. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.05.014 · Cited by 71
Treatment of dyspnoea in advanced cancer patients: ESMO Clinical Practice Guidelines
Kloke, M., & Cherny, N. I. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv306 · Cited by 72
“‘Antidepressants and buspirone’ are reputed to exert some antidyspnoeic efficacy as mood-enhancing medication; nevertheless, this has not yet been proven [69–78].”
BackgroundPrevalence of panic in patients referred for pulmonary function testing at a major medical center
Pollack, M. H., Kradin, R. L., Otto, M. W., Worthington, J., Gould, R. A., Sabatino, S. A., & Rosenbaum, J. F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.110 · Cited by 70
Management of the COPD Patient with Comorbidities: An Experts Recommendation Document
Iglesias, J. R., Díez‐Manglano, J., Garcı́a, F. L., Peromingo, J. A. D., Almagro, P., & Aguilar, J. M. V. (2020) · International Journal of COPD · doi:10.2147/copd.s242009 · Cited by 74
Sullivan, M. D., Newton, K. M., Hecht, J. A., Russo, J. E., & Spertus, J. A. (2004) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2004.03072.x · Cited by 62
Buganza‐Torio, E., Mitchell, N., Abraldes, J. G., Thomas, L., Ma, M., Bailey, R. J., & Tandon, P. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15068 · Cited by 60
Factors Associated with Depression in COPD: A Multicenter Study
Martínez‐Rivera, C., Costán, J., Navarrete, B. A., García-Polo, C., Iturriaga, L. A. R., Herrejón, A., Ros, J. A., García-Sidro, P., Tirado-Conde, G., López-Campos, J. L., et al. (2016) · Lung · doi:10.1007/s00408-016-9862-7 · Cited by 62
Peripheral arterial disease and depressed mood in older men and women
Arseven, A., Guralnik, J. M., O’Brien, E., Liu, K., & McDermott, M. M. (2001) · Vascular Medicine · doi:10.1177/1358836x0100600405 · Cited by 60
Metadata
- Authors
- Borson, S., McDonald, G. J., Gayle, T., Deffebach, M., Lakshminarayan, S., & VanTuinen, C.
- Affiliations
- University of Washington (US)
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 33
- Issue
- 2
- Pages
- 190-201
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2040089352
- Cited by
- 277
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- nortriptyline, depression, chronic obstructive pulmonary disease, antidepressant treatment, comorbid depression, mood improvement, somatic symptoms, functional capacity, anxiety, pulmonary insufficiency, placebo effect, severely disabled patients
- MeSH terms
- Activities of Daily Living, Affect, Attitude to Health, Chronic Disease, Depressive Disorder, Dyspnea, Female, Humans, Lung Diseases, Obstructive, Male, Middle Aged, Nortriptyline, Patient Compliance, Placebos, Prednisone, Psychiatric Status Rating Scales
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