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Bacteraemia complicating severe malaria in children
Abstract
Bacteraemia associated with severe malaria in childhood is a sporadically reported phenomenon but its incidence and clinical importance are unknown. We have reviewed clinical and laboratory data from 783 Kenyan children sequentially admitted with a primary diagnosis of severe malaria. The overall incidence of bacteraemia in children with severe malaria was 7.8% (95% CI 5.5-10.0); however, in children under 30 months of age the incidence was 12.0% (95% CI 8.3-15.7). The presence of bacteraemia was associated with a 3-fold increase in mortality (33.3% vs. 10.4%, P < 0.001). We conclude that invasive bacterial disease may contribute to the pathophysiology of the clinical syndrome of severe malaria in an important subgroup of children. We recommend that young children with severe malaria be treated with broad-spectrum antibiotics in addition to antimalarial drugs.
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Metadata
- Authors
- Berkley, J., Mwarumba, S., Bramham, K., Lowe, B., & Marsh, K.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-05
- Volume
- 93
- Issue
- 3
- Pages
- 283-286
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1978673956
- Cited by
- 213
- References
- 0
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berkley, J., Mwarumba, S., Bramham, K., Lowe, B., & Marsh, K. (1999). Bacteraemia complicating severe malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/s0035-9203(99)90024-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
