THE POTENTIAL ROLE OF THERAPEUTIC CYTOKINE MANIPULATION IN ACUTE PANCREATITIS
Abstract
The central, detrimental role of the inflammatory cytokines IL-1 and TNF and the biologically active phospholipid PAF in the pathogenesis of AP has been established over the past 8 years. A number of antagonists to these mediators have been used successfully in the laboratory setting and are currently being examined in prospective randomized trials. The effectiveness of any antagonist depends not only on its ability to block the effects of the inflammatory mediators but also on its administration early enough in the course of the pancreatitis before pancreatic necrosis or organ dysfunction.
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Cytokine overproduction is implicated in the pathogenesis of tissue damage and lethality in pancreatitis.
“Previous work implicated cytokine overproduction in the pathogenesis of tissue damage and lethality in pancreatitis (45)(46)(47).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [46]
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Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · see citing works
- Authors
- Denham, W., & Norman, J.
- Affiliations
- University of South Florida (US)
- Venue
- Surgical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 79
- Issue
- 4
- Pages
- 767-781
- ISSN
- 0039-6109 (ISSN-L)
- OpenAlex
- W2146243041
- Cited by
- 61
- References
- 74
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2012: 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgical Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- acute pancreatitis, necrotizing pancreatitis, systemic inflammatory response, pancreatic enzyme activation, antiprotease therapy, gabexate mesilate, peritoneal lavage, pancreatic ascites, organ dysfunction, acute respiratory distress syndrome, acute kidney injury, therapeutic target, cytokines, inflammatory mediators, morbidity and mortality
- MeSH terms
- Interleukin-6 Inhibitors, Acute Disease, Animals, Humans, Interleukin-1, Pancreatitis, Platelet Activating Factor, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Interleukin-8, Inflammation Mediators
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