Aluminum induced pulmonary granulomatosis
Abstract
The association of aluminum dusts and pulmonary fibrosis with emphysema in workers in the aluminum processing and manufacturing industries is well established. The early and minimal reactions of the lungs to the aluminum dusts are not known. This report presents the first case of pulmonary granulomatosis associated with aluminum inhalation. The occupational history of this patient was thoroughly examined, and the aluminum was identified by electron probe microanalysis of the lung biopsy specimen. The granulomatous response in this patient was similar to that observed in rabbits following aluminum dust inhalation. Hypersensitivity or individual idiosyncrasy may play a role in the development of the pulmonary granulomas following exposure to aluminum.
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Al-induced inflammation can be a chronic granulomatous type.
“The inflammation can be a chronic granulomatous type (Chen et al., 1978; de Vuyst et al., 1987; Forgarty et al., 1998; Gherardi and Authier, 2012)”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Chen et al., 1978
Pulmonary lesions in humans linked to Al exposure during production of Al products include granulomatous pneumonia, pulmonary granulomatosis, pulmonary fibrosis, pulmonary alveolar proteinosis and desquamative interstitial pneumonia.
“Pulmonary lesions in humans linked to Al exposure during production of Al products include granulomatous pneumonia, pulmonary granulomatosis, pulmonary fibrosis, pulmonary alveolar proteinosis and desquamative interstitial pneumonia (Chen et al., 1978; Herbert et al., 1982; Miller et al., 1984; De Vuyst et al., 1987; Jederlinic et al., 1990; Taiwo, 2014; Iijima et al., 2017).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Chen et al., 1978
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998 · see citing works
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395 · see citing works
“The inflammation can be a chronic granulomatous type (Chen et al., 1978; de Vuyst et al., 1987; Forgarty et al., 1998; Gherardi and Authier, 2012) and Al has been reported to cause granuloma formation in vitro (de Chambrun et al., 2014).”
BackgroundAluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice
Pineton de Chambrun, G., Body-Malapel, M., Frey-Wagner, I., Djouina, M., Deknuydt, F., Atrott, K., Esquerre, N., Altare, F., Neut, C., Arrieta, M. C., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.78 · Cited by 108 · see citing works
- Authors
- Chen, W.-J., Monnat, R. J., Chen, M., & Mottet, N. K.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 1978-11
- Volume
- 9
- Issue
- 6
- Pages
- 705-711
- ISSN
- 0046-8177 (ISSN-L)
- OpenAlex
- W2094617904
- Cited by
- 88
- References
- 0
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Physiology › Sarcoidosis and Beryllium Toxicity Research
- Keywords
- occupational exposure, granulomatous lung disease, pulmonary fibrosis, emphysema, hypersensitivity, idiosyncratic reactions, lung biopsy
- MeSH terms
- Adult, Aluminum, Granuloma, Humans, Lung, Lung Diseases, Male
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