Cited by 108Inflammatory Bowel DiseaseAluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and Toxicity

Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice

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Pineton de Chambrun, G, Body-Malapel, M, Frey-Wagner, I, Djouina, M, Deknuydt, F, Atrott, K, Esquerre, N, Altare, F +8 more·2014·Mucosal Immunology

Abstract

The increasing incidence of inflammatory bowel diseases (IBDs) in developing countries has highlighted the critical role of environmental pollutants as causative factors in their pathophysiology. Despite its ubiquity and immune toxicity, the impact of aluminum in the gut is not known. This study aimed to evaluate the effects of environmentally relevant intoxication with aluminum in murine models of colitis and to explore the underlying mechanisms. Oral administration of aluminum worsened intestinal inflammation in mice with 2,4,6-trinitrobenzene sulfonic acid- and dextran sodium sulfate-induced colitis and chronic colitis in interleukin 10-negative (IL10(-/-)) mice. Aluminum increased the intensity and duration of macroscopic and histologic inflammation, colonic myeloperoxidase activity, inflammatory cytokines expression, and decreased the epithelial cell renewal compared with control animals. Under basal conditions, aluminum impaired intestinal barrier function. In vitro, aluminum induced granuloma formation and synergized with lipopolysaccharide to stimulate inflammatory cytokines expression by epithelial cells. Deleterious effects of aluminum on intestinal inflammation and mucosal repair strongly suggest that aluminum might be an environmental IBD risk factor.

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Authors
Pineton de Chambrun, G., Body-Malapel, M., Frey-Wagner, I., Djouina, M., Deknuydt, F., Atrott, K., Esquerre, N., Altare, F., Neut, C., Arrieta, M. C., Kanneganti, T.-D., Rogler, G., Colombel, J.-F., Cortot, A., Desreumaux, P., & Vignal, C.
Affiliations
  • University Hospital Zurich (CH)
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
  • University of British Columbia (CA)
  • St. Jude Children's Research Hospital (US)
Corresponding author
Vignal, C
Venue
Mucosal Immunology
Publisher
Elsevier BV
Published
2014-05
Volume
7
Issue
3
Pages
589-601
ISSN
1933-0219 (ISSN-L)
OpenAlex
W2087971582
Cited by
108
References
53
Citations by year
2026: 4 · 2025: 8 · 2024: 11 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 5 · 2014: 3
FWCI
3.98
Type
journal article
Language
en
Open access
Locations
  • Mucosal Immunology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • HAL (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Centre National de la Recherche Scientifique
  • European Regional Development Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
aluminum, inflammatory bowel disease, colitis, intestinal inflammation, mucosal healing, environmental pollutants, TNBS-induced colitis, DSS-induced colitis, IL-10 knockout mice, intestinal barrier function, epithelial cell renewal, myeloperoxidase, inflammatory cytokines, granuloma formation, lipopolysaccharide
MeSH terms
Aluminum, Animals, Cell Line, Chronic Disease, Colitis, Disease Models, Animal, Gene Expression Regulation, Granuloma, Humans, Intestinal Mucosa, Male, Phosphates, Trinitrobenzenesulfonic Acid, Wound Healing, Inflammatory Bowel Diseases, Cytokines, Interleukin-10, Aluminum Compounds, Mice, Knockout, Inflammation Mediators, Mice

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