Differential regulation of CD8+ T cell senescence in mice and men
Abstract
The cytotoxic CD8+ T cell population expands considerably during acute immune infection with virus. Most of these cells are removed by apoptosis at the end of the immune response. However, a balance has to be attained between clearance and retention of a memory population of cells, which respond more rapidly and efficiently to secondary encounter with the antigen. In this article, the role of apoptosis and in particular the development of replicative senescence as mechanisms which control this homeostatic balance are discussed. Although similar mechanisms regulate apoptosis in both humans and rodents, the available data suggests that replicative senescence may be controlled differently in these species, suggesting the there may be different constraints in the regulation of CD8+ T cell memory between different species.
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Numerous aspects of immune and cellular senescence have been documented in the elderly, but only a few of them have been extended to studies in HIV-infected individuals.
“There are numerous aspects of immune and cellular senescence that have been documented in the elderly but only a few of them have been extended to studies in HIV-infected individuals (31,32).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [31]
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- Authors
- Akbar, A. N., Soares, M. V. D., Plunkett, F. J., & Salmon, M.
- Affiliations
- Royal Free London NHS Foundation Trust (GB)
- The Royal Free Hospital (GB)
- University of Birmingham (GB)
- Corresponding author
- Akbar, Arne N
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 121
- Issue
- 1-3
- Pages
- 69-76
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2036103725
- Cited by
- 46
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 2 · 2017: 1 · 2015: 3 · 2014: 1 · 2012: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- CD8+ T cells, replicative senescence, cytotoxic T lymphocytes, apoptosis, T cell memory, homeostatic balance, viral infection, species differences
- MeSH terms
- Acute Disease, Aging, Animals, Cell Division, Humans, Virus Diseases, Telomere, Cellular Senescence, CD8-Positive T-Lymphocytes, Mice
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