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“Studies examining CD4+ T-helper (Th) cells in the context of ageing, have traditionally shown, based on their signature cytokine profiles, that cells exhibiting a Th2 profile (i.e., IL-4 producing cells) dominate over cells with a Th1 profile (i.e., IFN-γ producing cells) in the elderly (Deng et al. 2004; Shearer 1997).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Shearer 1997
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“Indeed with aging a shift toward a pro-allergenic Th2 profile (27, 33, 34) may take place, at the point that a Th2 profile may not only be characteristic of childhood, but also be present in mid-to-later life (35, 36) therefore influencing the development of FA in older people (28).”
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Metadata
- Authors
- Shearer, G. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- G M Shearer
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 94
- Issue
- 1-3
- Pages
- 1-5
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W143197739
- Cited by
- 174
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 1 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 10 · 2012: 5
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- blood-CSF barrier, choroid plexus epithelium, contrast-enhanced MRI, gadolinium enhancement, blood-CSF barrier permeability, age-related neurodegeneration, manganese contrast agent, cerebrospinal fluid homeostasis
- MeSH terms
- Aging, Animals, Humans, Cytokines, Th1 Cells, Th2 Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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