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Cited by 19Tuberculosis Research and EpidemiologyParasites and Host InteractionsImmune Response and Inflammation

Differential effects of ageing on cytokine and chemokine responses during type-1 (Mycobacterial) and type-2 (Schistosomal) pulmonary granulomatous inflammation in mice

Chiu, Bo Chin, Shang, Xiaozhou, Frait, Kirsten A, Hu, Jerry S, Komuniecki, Eric, Miller, Richard A, Chensue, Stephen W·2002·Mechanisms of Ageing and Development
DOI 10.1016/s0047-6374(01)00372-4
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Abstract

Cytokine and chemokine responses during anamnestic type-1 and type-2 lung granuloma formation were evaluated in mice at 6,12,18 and 24-months of age. Lesions were induced by embolizing Sepharose beads coupled to Mycobacterium bovis purified protein derivative or soluble Schistosoma mansoni egg antigens. Type-1 inflammation was reduced by 18 months, whereas type-2 granulomas not until 24 months of age. In type-1 draining lymph nodes cultures, interferon-gamma (IFNgamma) declined to a nadir by 18, and then partly recovered at 24 months. In contrast, IL-4 was not significantly impaired in type-2 cultures until 24 months. Type-1 and 2 node cultures also displayed decreased IL-13, but paradoxically enhanced IL-5 production at 24 months. Chemokine transcripts in granulomatous lungs displayed age-related alterations. In the type-1 response, CXCL9 (monokine-induced by IFNgamma) declined with age then partly recovered at 24 months parallelling lymph node IFNgamma levels. Transcripts for MIP-2/CXCL2, IP-10/CXCL10, MCP-1/CCL2, and MCP-5/CCL12 increased at 24 months. In the type-2 response MCP-1/CCL2, MCP-3/CCL7, MCP-5/CCL12 and TARC/CCL17 collapsed at 24 months paralleling local IL-4 transcript levels, yet some chemokine transcripts such as KC/CXCL1 and eotaxin/CCL11 were unaffected. These findings suggest that cytokine and chemokine responses degrade differentially with age shifting Th1/Th2 crossregulatory pressures and local expression of chemokines.

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Authors
Chiu, B. C., Shang, X., Frait, K. A., Hu, J. S., Komuniecki, E., Miller, R. A., & Chensue, S. W.
Affiliations
University of Michigan (US)
ORCID
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2002-02
Volume
123
Issue
4
Pages
313-326
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/s0047-6374(01)00372-4
OpenAlex
W2075503686
Cited by
19
References
43
Citations by year
2021: 1 · 2015: 1 · 2014: 1 · 2013: 2
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5t32ai007413-32)
  • National Institute on Aging (AG-08808)
  • National Heart, Lung, and Blood Institute (HL07517, T32HL007517)
  • National Institute of Allergy and Infectious Diseases (AI43460, AI07413)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
aging, pulmonary granuloma, type 1 inflammation, type 2 inflammation, Mycobacterium bovis BCG, cytokine response, chemokines, interferon-gamma, IL-4, IL-13, IL-5, CXCL9, CCL2/MCP-1, Th1/Th2 balance, age-related immune decline
MeSH terms
Aging, Animals, Lung, Lymph Nodes, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mycobacterium bovis, Schistosoma mansoni, Schistosomiasis mansoni, Tuberculosis, Granuloma, Respiratory Tract, Cytokines, Chemokines, Mice

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