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Analysis of aluminium in serum and urine for the biomonitoring of occupational exposure
Abstract
A reliable and sensitive graphite furnace atomic absorption spectrometry (GFAAS) method with Zeeman background correction was developed for the analysis of aluminium in serum and urine in the biological monitoring of aluminium exposure. The method is based on platform atomisation in pyrolytically coated graphite tubes after fourfold dilution with nitric acid. For serum analysis, a matrix matched standard curve is prepared and for urine the method of standard additions is used. The within-run imprecision (C.V.) for serum and urine was 3% and 5%, and the between-day imprecision, 6% and 7.2%, at a concentration level of 4.0 mumol/l. The between-day imprecision for urinary aluminium was 15.7% at a concentration level of 0.24 mumol/l. The detection limits were 0.02 mumol/l for serum and 0.07 mumol/l for urine. During 1 year of participation in TEQAS external quality assessment scheme of the Robens Institute for Health and Safety (Guildford, UK) for serum aluminium the maximum cumulative performance score was achieved. For urinary aluminium a certificate in the external quality control scheme of the German Society of Occupational Medicine was obtained. The mean concentration of aluminium in a non-exposed population, who did not use antacid drugs, was 0.06 mumol/l (S.D. 0.03, range 0.02-0.13, n = 21) in serum, and 0.33 mumol/l (S.D. 0.18, range 0.07-0.82, n = 44) in urine. The upper reference limit for aluminium in a healthy, non-exposed population was estimated to be 0.1 mumol/l in…
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“The migration of Al from cookware into food increases with the acidity of the food and the duration of exposure (Valkonen and Aitio, 1997; Lin et al. 1997).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Valkonen and Aitio, 1997
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Research works printed but not linked: 23
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Cited by
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“The mean serum Al level in 44 non-exposed persons who did not use antacids was reported to be 1.6 μg/L (Valkonen and Aitio, 1997) and Chen et al. (2010) reported that values in hemodialysis patients were ten-fold higher than the values in unexposed individuals.”
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Metadata
- Authors
- Valkonen, S., & Aitio, A.
- Affiliations
- Finnish Institute of Occupational Health (FI)
- Corresponding author
- Valkonen, Sinikka
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 199
- Issue
- 1-2
- Pages
- 103-110
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2079979473
- Cited by
- 49
- References
- 0
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- aluminum, occupational exposure, biomonitoring, serum aluminum, graphite furnace atomic absorption spectrometry, Zeeman background correction, reference limits, antacids, external quality assessment
- MeSH terms
- Adult, Aluminum, Calibration, Environmental Monitoring, Female, Finland, Graphite, Humans, Male, Metallurgy, Occupational Medicine, Quality Control, Reference Standards, Spectrophotometry, Atomic, Reproducibility of Results, Occupational Exposure
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