Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

Cites (748)

Items 201–400 of 748

1. The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer
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2. A newly defined interleukin-1?
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4. Regulation of Interleukin-12 by Complement Receptor 3 Signaling
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5. Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2
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6. T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.
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7. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.
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8. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
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9. Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation
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10. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.
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11. Interleukin‐12 production by human polymorphonuclear leukocytes
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12. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.
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13. Cytokine receptors and signal transduction
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14. Expression of IL-12 and IL-13 mRNA in Asthma and Their Modulation in Response to Steroid Therapy
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15. Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.
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16. Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes
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17. The role of IL-12 in the induction of organ-specific autoimmune diseases
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18. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.
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19. The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells
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20. IL-12 production by central nervous system microglia is inhibited by astrocytes
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21. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production
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22. Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells
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23. Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells
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24. IL-1 β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1 β in the T cell-independent mechanism of resistance against intracellular pathogens
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25. Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.
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26. Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
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27. Regulation of NK cell functions by TGF-β 1
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28. A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells
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29. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages
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30. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome
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31. A T cell-independent mechanism of macrophage activation by interferon-gamma.
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32. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice
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33. Adjuvant modulation of immune responses to tuberculosis subunit vaccines
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34. Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor
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35. Effects of IL-12 on the response and susceptibility to experimental viral infections.
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36. Stat4, a Novel Gamma Interferon Activation Site-Binding Protein Expressed in Early Myeloid Differentiation
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37. Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10 [see comments]
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38. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
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39. In vivo production and function of IL-12 p40 homodimers
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40. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.
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41. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.
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42. IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.
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43. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis
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44. Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.
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45. Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction
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46. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon
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47. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ
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48. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection.
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49. Interleukin 12 at the site of disease in tuberculosis.
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50. Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma.
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51. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
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52. CD8+ T cells can be primed in vitro to produce IL-4
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53. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.
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54. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.
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55. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN- gamma gene.
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56. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor
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57. Interleukin-12 Inhibits Antigen-Induced Airway Hyperresponsiveness in Mice
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58. Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.
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59. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.
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60. IL-12 enhances Th1-type responses in human Leishmania donovani infections.
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61. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.
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62. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
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63. Induction and prevention of colonic inflammation in IL-2-deficient mice
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64. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
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66. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice
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67. Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.
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68. Interleukin-18 Activates NF-κB in Murine T Helper Type 1 Cells
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69. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
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75. Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12
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80. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia
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90. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice
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91. Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice
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92. Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma
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93. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
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94. Amount of interleukin 12 available at the tumor site is critical for tumor regression.
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95. Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro
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96. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Bechçet's disease; soluble TNFR-75 as a biological marker of disease activity.
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97. Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation
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98. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions
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99. Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.
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100. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
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101. Liver NK1.1+ CD4+ αβ T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis
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102. Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12.
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103. An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production
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104. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-α
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105. Human dendritic cells phagocytose and process Borrelia burgdorferi
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106. Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12
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107. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation.
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108. Microbial products induce autoimmune disease by an IL-12-dependent pathway
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109. Cooperation of Natural Killer Cell Stimulatory Factor/Interleukin-12 with Other Stimuli in the Induction of Cytokines and Cytotoxic Cell-Associated Molecules in Human T and NK Cells
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110. ARE Th2 HELPER T LYMPHOCYTES BENEFICIAL, DELETERIOUS, OR IRRELEVANT IN PROMOTING ALLOGRAFT SURVIVAL?1
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111. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.
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113. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis
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114. Administration of Interleukin 12 With Pulse Interleukin 2 and the Rapid and Complete Eradication of Murine Renal Carcinoma
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115. Intracellular Antimicrobial Activity in the Absence of Interferon-γ: Effect of Interleukin-12 in Experimental Visceral Leishmaniasis in Interferon-γ Gene-disrupted Mice
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116. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse
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117. Interleukin‐12 induces interferon‐γ‐dependent switching of IgG alloantibody subclass
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118. Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12
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119. Stability of Th1 and Th2 populations
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120. Cloning and characterization of a mouse IL-12 receptor-β component
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121. Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes
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122. Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo
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123. Transforming growth factor‐β inhibits interleukin‐12‐induced production of interferon‐γ by natural killer cells: A role for transforming growth factor‐β in the regulation of T cell‐independent resistance to Toxoplasma gondii
     Christopher A. Hunter, Luiz Eduardo Bermudez, Hans Beernink, Wendy Waegell, Jack S. Remington · 1995 · European Journal of Immunology
124. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms
     Yifan Zhan, Z Liu, Christina Cheers · 1996 · Infection and Immunity
125. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.
     Yasir A. W. Skeiky, Jeffrey A. Guderian, Darin R. Benson, O Bacelar, Edgar M. Carvalho, Marek Z. Kubin, Roberto José da Silva Badaró, Giorgio Trinchieri, Steven G. Reed · 1995 · The Journal of Experimental Medicine
126. Interleukin‐12 Production by Dendritic Cells
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127. Comparative sequence analysis of cytokine genes from human and nonhuman primates
     Francois J. Villinger, S S Brar, Ann E. Mayne, Nathaniel F. Chikkala, Aftab Ahmed Ansari · 1995 · The Journal of Immunology
128. IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans
     Kazuyoshi Kawakami, Masaki Tohyama, Qiang-min Xie, Atsushi Saitô · 1996 · Clinical & Experimental Immunology
129. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice
     Wen Juan Dai, W Bartens, Georges Köhler, Markus Hufnagel, Manfred Köpf, Frank Brombacher · 1997 · The Journal of Immunology
130. Dual role of IL-12 in early and late stages of murine collagen type II arthritis
     Leo A. B. Joosten, Erik Lubberts, M.M. Helsen · 1997 · The Journal of Immunology
131. Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin‐12) on cell‐mediated cytotoxicity against tumor‐derived and virus‐infected cells
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132. Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12
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133. Vitamin A deficiency results in a priming environment conducive for Th1 cell development
     Margherita T. Cantorna, Faye E. Nashold, Colleen E. Hayes · 1995 · European Journal of Immunology
134. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer
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135. Effect of interleukin 12 on tumor induction by 3-methylcholanthrene.
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136. IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes
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137. Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses
     Sanjiv Sur, Jonathan Lam, Page R. Bouchard · 1996 · The Journal of Immunology
138. Sterile protection of monkeys against malaria after administration of interleukin-12
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139. The Immune Microenvironment of Human Fracture/Soft-tissue Hematomas and its Relationship to Systemic Immunity
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140. Interleukin‐12 Antagonist Activity of Mouse Interleukin‐12 p40 Homodimer in Vitro and in Vivo
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141. Differential Associations between the Cytoplasmic Regions of the Interleukin-12 Receptor Subunits β1 and β2 and JAK Kinases
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142. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response
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143. Identification and induction of human keratinocyte-derived IL-12.
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144. Polyinosinic acid: polycytidylic acid promotes T helper type 1‐specific immune responses by stimulating macrophage production of interferon‐α and interleukin‐12
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145. Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5
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146. Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter
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147. IL-12 regulates T helper type 1 cytokine responses in human infectious disease.
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148. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo
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149. Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.
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150. Interleukin-12 Prevents Ultraviolet B-Induced Local Immunosuppression and Overcomes UVB-Induced Tolerance
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151. LPS induces NK1.1+ αβ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells
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152. Close phenotypic and functional similarities between human and murine αβ T cells expressing invariant TCR α-chains
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153. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis
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154. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.
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155. Defects of monocyte interleukin 12 production and humoral immunity in Whipple's disease
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156. Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells
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157. IL-15 enhances immune functions during HIV infection
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158. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity
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159. Differential effects of interleukin‐12 on the development of naive mouse CD4+ T cells
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160. Comparison of the effects of interleukin‐1α, interleukin‐lβ and interferon‐γ‐inducing factor on the production of interferon‐γ by natural killer
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161. Activation of gamma delta T cells for production of IFN- gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12.
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162. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype
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163. IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-γ production in NK cells and CD4+ T cells
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164. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN- gamma .
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165. IL-12 augments antigen-dependent proliferation of activated T lymphocytes
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166. IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.
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167. Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus
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168. IL-12 reverses cytokine and immune abnormalities in Sezary syndrome.
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169. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness
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170. Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.
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171. Sequence similarity between NKSF and the IL-6/G-CSF family
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172. Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin‐12 for interferon‐γ production
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173. Expression of interferon-gamma (IFN-δ), IL-10, IL-12 and transforming growth factor-beta (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA)
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174. BONE MARROW–DERIVED DENDRITIC CELLS, INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS, AND IMMUNOPATHOLOGY
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175. Oral but Not Parenteral Interleukin (IL)-12 Redirects T Helper 2 (Th2)-type Responses to an Oral Vaccine Without Altering Mucosal IgA Responses
     Mariarosaria Marinaro, Prosper N. Boyaka, Fred D. Finkelman, Hiroshi Kiyono, Raymond J. Jackson, Emilio Jirillo, Jerry R. McGhee · 1997 · The Journal of Experimental Medicine
176. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.
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177. Interleukin (IL)‐4 production by human T cells: differential regulation of IL‐4 vs. IL‐2 production
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178. Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation.
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179. Role of interferon-gamma in interleukin 12-induced pathology in mice.
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180. Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors
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181. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection
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182. Regulation of cytokine expression in macrophages and the Langerhans cell-like line XS52 by calcitonin gene-related peptide
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183. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficientop/op mouse: Evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma
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184. CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes
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185. Purification of a factor which provides a costimulatory signal for gamma interferon production
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186. Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12.
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187. Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2
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188. Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid
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189. IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
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190. IL-12 induces human T cells secreting IL-10 with IFN-γ
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191. Interleukin-12 inhibits murine graft-versus-host disease
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192. Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state
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193. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state
     Ursula Grohmann, Roberta Bianchi, Emira Ayroldi, Maria Laura Belladonna, Daniela Surace, Maria C. Fioretti, Paolo Puccetti · 1997 · The Journal of Immunology
194. CD30 defines a subset of activated human T cells that produce IFN-gamma and IL-5 and exhibit enhanced B cell helper activity.
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195. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection
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196. Interleukin-12 gene expression after viral infection in the mouse
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197. IL‐12‐Deficient Mice Are Defective but Not Devoid of Type 1 Cytokine Responses
     Jeanne Magram, JESSICA SFARRA, Suzanne E. Connaughton, D A Faherty, Rajeev R. Warrier, Daisy M. Carvajal, Chang You Wu, Colin L. Stewart, Ulla M. Sarmiento, Maurice K. Gately · 1996 · Annals of the New York Academy of Sciences
198. Calcitonin Gene-Related Peptide Inhibits Proliferation and Antigen Presentation by Human Peripheral Blood Mononuclear Cells: Effects on B7, Interleukin 10, and Interleukin12
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199. Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis
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200. Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: effects of interleukin-12
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