Cited by 760Cytokine Signaling Pathways and InteractionsImmune Response and InflammationT-cell and B-cell Immunology

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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

Trinchieri, Giorgio·1998·Advances in Immunology

DOI 10.1016/s0065-2776(08)60387-9

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Shaw, J., Meerovitch, K., Elliott, J. F., et al. (1987) · Molecular Immunology · doi:10.1016/0161-5890(87)90014-9 · Cited by 82
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Vieira, L. Q., Hondowicz, B. D., Afonso, L., et al. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)90187-2 · Cited by 82
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Rabinowich, H., Herberman, R. B., & Whiteside, T. L. (1993) · Cellular Immunology · doi:10.1006/cimm.1993.1306 · Cited by 82
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CD2 regulates responsiveness of activated T cells to interleukin 12.
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Locksley, R. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.5.1405 · Cited by 80
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Rossi, A., Pericle, F., Rashleigh, S., et al. (1994) · Blood · doi:10.1182/blood.v83.5.1323.1323 · Cited by 79
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Miller, M. A., Skeen, M. J., & Ziegler, H. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.4817 · Cited by 79
Interferon‐γ and interleukin‐4 regulate T cell interleukin‐12 responsiveness through the differential modulation of high‐affinity interleukin‐12 receptor expression
Gollob, J., Kawasaki, H., & Ritz, J. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270311 · Cited by 79
Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.
Vagliani, M., Rodolfo, M., Cavallo, F., et al. (1996) · PubMed · Cited by 78
Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL.
Bloom, E. T., & Horvath, J. A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.9.4242 · Cited by 78
Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats
Chung, Y. H., Jun, H., KANG, Y. Y., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.466 · Cited by 78
Interleukin‐12 but not interferon‐γ production correlates with induction of T helper type‐1 phenotype in murine candidiasis
Romani, L. R., Mencacci, A., Tonnetti, L., Spaccapelo, R., Cenci, E., Wolf, S. F., Puccetti, P., & Bistoni, F. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240419 · Cited by 78
Molecular interaction between CD58 and CD2 counter-receptors mediates the ability of monocytes to augment T cell activation by IL-12
Gollob, J., Li, J., Kawasaki, H., Daley, J. F., Groves, C., Reinherz, E. L., & Ritz, J. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.1886 · Cited by 77
High IL-6 and Low IL-10 in the Central Nervous System Are Associated with Protracted Relapsing EAE in DA Rats
Diab, A., Zhu, J., Xiao, B. G., Mustafa, M., & Link, H. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199706000-00002 · Cited by 77
Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes
Tone, Y., Thompson, S. A. J., Babik, J. M., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260606 · Cited by 77
IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.
Armant, M. A., Delespesse, G., & Sarfati, M. (1995) · PubMed · Cited by 76
B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.
Benjamin, D., Sharma, V., Knobloch, T. J., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.4749 · Cited by 76
Pathogenesis of the natural killer cell deficiency in AIDS
Sirianni, M. C., Tagliaferri, F., & Aiuti, F. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90032-5 · Cited by 76
Regulation of transforming growth factor‐β production by interleukin‐12
Marth, T., Strober, W., Seder, R. A., & Kelsall, B. L. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270524 · Cited by 76
Cytokine cross‐talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity
Trinchieri, G., Kubin, M. Z., Bellone, G., & Cassatella, M. A. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530406 · Cited by 76
Self-citation
Initiation of T-Helper Cell Immunity to Candida albicans by IL-12: The Role of Neutrophils
Romani, L. R., Bistoni, F., & Puccetti, P. (1997) · KARGER eBooks · doi:10.1159/000058688 · Cited by 76
Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma.
Goodman, R. E., Nestle, F. O., Naidu, Y. M., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.11.5189 · Cited by 75
The important balance between cytokines derived from type 1 and type 2 helper T cells in the control of graft-versus-host disease
Tanaka, J., Imamura, M., Kasai, M., et al. (1997) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1700708 · Cited by 75
Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression.
Kinter, A. L., Bende, S. M., Hardy, E. C., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.10985 · Cited by 75
Differential expression of mRNA encoding interleukin‐12 p35 and p40 subunits in situ
Bette, M., Jin, S., Germann, T., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241026 · Cited by 75
Interleukin-12 enhances peripheral hematopoiesis in vivo
Jackson, J., Yan, Y., Brunda, M., et al. (1995) · Blood · doi:10.1182/blood.v85.9.2371.bloodjournal8592371 · Cited by 75
High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin 12.
Meko, J. B., Yim, J., Tsung, K., et al. (1995) · PubMed · Cited by 74
In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12.
Wu, C. Y., Demeure, C. E., Gately, M. K., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.1141 · Cited by 74
Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci
Mancuso, G., Cusumano, V., Genovese, F., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3731-3735.1997 · Cited by 74
Default development of cloned human naive CD4 T cells into interleukin‐4‐ and interleukin‐5‐producing effector cells
Yang, L., Byun, D., Demeure, C. E., et al. (1995) · European Journal of Immunology · doi:10.1002/eji.1830251247 · Cited by 74
Cytokine Gene Expression during the Elicitation Phase of Contact Sensitivity: Regulation By Endogenous IL-4
Asada, H., Linton, J. T., & Katz, S. I. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12289700 · Cited by 74
Cytokine Gene Therapy of Cancer Using Interleukin‐12: Murine and Clinical Trials
Lotze, M. T., Zitvogel, L., Campbell, R. L., Robbins, P. D., Elder, E. M., Haluszczak, C., Martin, D. M., Whiteside, T. L., Storkus, W. J., & Tahara, H. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb52715.x · Cited by 74
Behavior of Visceral Leishmania donovani in an Experimentally Induced T Helper Cell 2 (Th2)-Associated Response Model
Murray, H. W., Hariprashad, J., & Coffman, R. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.867 · Cited by 74
Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum
Zhou, P., Sieve, M. C., Tewari, R. P., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.3.936-942.1997 · Cited by 73
Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.
Waldburger, K. E., Hastings, R. C., Schaub, R. G., et al. (1996) · PubMed · Cited by 72
Expression of mRNA for Interferon-Gamma, Interleukin-10, and Interleukin-12 (p40) in Normal Gastric Mucosa and in Mucosa Infected withHelicobacter pylori
Karttunen, R. A., Karttunen, T. J., Yousfi, M. M., et al. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709025058 · Cited by 72
Rapidly expanded activated human killer cell clones have strong antitumor cell activity and have the surface phenotype of either T gamma, T-non-gamma, or null cells.
van de Griend, R. J., Krimpen, B. A. V., Ronteltap, C. P. M., et al. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.6.3185 · Cited by 71
Interleukin-12 Prevents Antigen-Induced Eosinophil Recruitment Into Mouse Airways
Iwamoto, I., Kumano, K., Kasai, M., Kurasawa, K., & Nakao, A. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.5.8912732 · Cited by 71
PHOTOBIOLOGY SCHOOL
Kripke, M. L. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb08703.x · Cited by 71
Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56+ natural killer cells stimulated with interleukin‐2, interleukin‐7 and interleukin‐12
Naume, B., Johnsen, A., Espevik, T., & Sundan, A. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230815 · Cited by 71
The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.
Coughlin, C. M., Wysocka, M., Trinchieri, G., & Lee, W. M. F. (1997) · PubMed · Cited by 69
Self-citation
In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin
Bost, K. L., & Clements, J. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.1076-1083.1995 · Cited by 69
Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis.
Bonnema, J. D., Rivlin, K., Ting, A. T., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2098 · Cited by 69
Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12
Noll, A., & AutenriethIB (1996) · Infection and Immunity · doi:10.1128/iai.64.8.2955-2961.1996 · Cited by 69
Natural killer cells in intravenous drug abusers with lymphadenopathy syndrome.
Poli, G., Introna, M., Zanaboni, F., Peri, G., Carbonari, M., Aiuti, F., Lazzarin, A., Moroni, M., & Mantovani, A. (1985) · PubMed Central · Cited by 69
Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma model.
Tan, J., Newton, C. A., Djeu, J. Y., et al. (1996) · PubMed · Cited by 68
Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis.
Bellone, G., & Trinchieri, G. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.3.930 · Cited by 68
Self-citation
Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for the antitumor activity of interleukin 12 and/or interleukin 2.
Wigginton, J. M., Kuhns, D. B., Back, T. C., Brunda, M. J., Wiltrout, R. H., & Cox, G. W. (1996) · PubMed · Cited by 68
IL‐12 eliminates the Th‐2 dependent protective immune response of mice to larval Strongyloides stercoralis
Rotman, H. L., Schnyder‐Candrian, S., Scott, P., et al. (1997) · Parasite Immunology · doi:10.1046/j.1365-3024.1997.d01-142.x · Cited by 68
Interleukin-12 Inhibits Angiogenesis Induced by Human Tumor Cell Lines In Vivo
Majewski, S. T., Marczak, M., Szmurło, A., Jabłońska, S., & Bollag, W. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12340161 · Cited by 68
Correlation between Induction of Lymphocyte Apoptosis and Prostaglandin E2 Production by Macrophages Infected with HIV
Mastino, A., Grelli, S., Piacentini, M., et al. (1993) · Cellular Immunology · doi:10.1006/cimm.1993.1272 · Cited by 67
Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin‐12
Yokoi, H., Kato, K., Kezuka, T., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270310 · Cited by 67
IL-12 transiently induces IFN-γ transcription and protein synthesis in human CD4 + allergen-specific Th2 T cell clones
Yssel, H., Fasler, S., de Vries, J. E., et al. (1994) · International Immunology · doi:10.1093/intimm/6.7.1091 · Cited by 67
Functional interaction between TGF-beta and IL-12 in human primary allogeneic cytotoxicity and proliferative response
Pardoux, C., Asselin‐Paturel, C., Chehimi, J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.1.136 · Cited by 66
IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.
DeKruyff, R. H., Fang, Y., Wolf, S. F., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2578 · Cited by 66
Human Immunodeficiency Virus gp120 Inhibits Interleukin-12 Secretion by Human Monocytes: An Indirect Interleukin-10–Mediated Effect
Taoufik, Y., Lantz, O. J., Wallon, C., et al. (1997) · Blood · doi:10.1182/blood.v89.8.2842 · Cited by 65
Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells
Sartori, A., de Oliveira, M. A. P., Scott, P., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.2849 · Cited by 65
High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4+ T cells for IFN-γ but have differential effects on priming for IL-4
Seder, R. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2413 · Cited by 65
Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages
Yoshida, A., & Koide, Y. (1997) · Infection and Immunity · doi:10.1128/iai.65.5.1953-1955.1997 · Cited by 65
Interleukin-12 Treatment during Immunization Elicits a T Helper Cell Type 1-like Immune Response in Mice Challenged with Respiratory Syncytial Virus and Improves Vaccine Immunogenicity
Tang, V.-W., & Graham, B. S. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.3.734 · Cited by 65
Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages
Bost, K. L., & Clements, J. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3186-3192.1997 · Cited by 65
Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication
Foli, A., Saville, M. W., Baseler, M., & Yarchoan, R. (1995) · Blood · doi:10.1182/blood.v85.8.2114.bloodjournal8582114 · Cited by 64
Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme
Buchanan, J. M., Vogel, L. A., Cleave, V. H. V., et al. (1995) · International Immunology · doi:10.1093/intimm/7.9.1519 · Cited by 64
Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues
Hofmann, B., Nishanian, P., Nguyen, T. D., et al. (1993) · AIDS · doi:10.1097/00002030-199305000-00008 · Cited by 63
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions
Maruo, S., Oh‐hora, M., Ahn, H., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.1.120 · Cited by 63
IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones
Maruo, S., Toyo‐oka, K., Oh‐hora, M., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.5.1748 · Cited by 63
Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp
Chong, C., Bost, K. L., & Clements, J. D. (1996) · Infection and Immunity · doi:10.1128/iai.64.4.1154-1160.1996 · Cited by 63
IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation.
Neta, R., Stiefel, S., Finkelman, F. D., HERRMANN, S. H., & Ali, N. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.9.4230 · Cited by 62
Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals
Palmer, E. M., & van Seventer, G. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2654 · Cited by 62
IL-12 treatment attenuates T helper cell type 2 and B cell responses but does not improve vaccine-enhanced lung illness
Hussell, T., Khan, U., & Openshaw, P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.328 · Cited by 62
Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes
Ludviksson, B. R., Gray, B., Strober, W., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.1.104 · Cited by 62
Construction and Biological Characterization of an Interleukin-12 Fusion Protein (Flexi-12): Delivery to Acute Myeloid Leukemic Blasts Using Adeno-Associated Virus
Anderson, R. J., Macdonald, I., Corbett, T., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.9-1125 · Cited by 62
A cytokine switch induced by human seminal plasma: an immune modulation with implications for sexually transmitted disease
KELLY, R. W., Carr, G. G., & Critchley, H. (1997) · Human Reproduction · doi:10.1093/humrep/12.4.677 · Cited by 62
Brucella abortus as a potential vaccine candidate: induction of interleukin-12 secretion and enhanced B7.1 and B7.2 and intercellular adhesion molecule 1 surface expression in elutriated human monocytes stimulated by heat-inactivated B. abortus
Zaitseva, M. B., Golding, H., Manischewitz, J. F., et al. (1996) · Infection and Immunity · doi:10.1128/iai.64.8.3109-3117.1996 · Cited by 62
Measurement of Human and Mouse Interleukin‐12
Gately, M. K., Chizzonite, R., & Presky, D. H. (1995) · Current Protocols in Immunology · doi:10.1002/0471142735.im0616s15 · Cited by 61
Possible role of anti-idiotypic antibodies in the induction of tumor immunity.
Kennedy, R. C., Zhou, E., Lanford, R. E., et al. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113195 · Cited by 61
Preferential expression of interleukin‐12 or interleukin‐4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin‐3
Smith, T. J., Ducharme, L. A., & Weis, J. H. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240408 · Cited by 61
Lack of IL-12 signaling in human allergen-specific Th2 cells
Hilkens, C. M. U., Messer, G., Tesselaar, K., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4316 · Cited by 60
Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines
Rodolfo, M., Zilocchi, C., Melani, C. C., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.12.5536 · Cited by 60
T cell source of type 1 cytokines determines illness patterns in respiratory syncytial virus-infected mice.
Tang, Y., & Graham, B. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119391 · Cited by 60
Direct binding of IL-12 to human and murine B lymphocytes
Vogel, L. A., Showe, L. C., Lester, T. L., et al. (1996) · International Immunology · doi:10.1093/intimm/8.12.1955 · Cited by 60
Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection
Matsyo, R., Kobayashi, M., Herndon, D. N., et al. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.5.623 · Cited by 60
Fc gamma RIIIA-mediated signaling involves src -family lck in human natural killer cells.
Pignata, C., Prasad, K. V. S., Robertson, M. J., Levine, H., Rudd, C. E., & Ritz, J. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.12.6794 · Cited by 59
IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells
Bianchi, R., Grohmann, U., Belladonna, M. L., Silla, S., Fallarino, F., Ayroldi, E., Fioretti, M. C., & Puccetti, P. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1589 · Cited by 59
Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.
Milich, D. R., Wolf, S. F., Hughes, J. L., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6847 · Cited by 59
Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas mice with renal injury
Fan, X., Oertli, B., & Wuthrich, R. P. (1997) · Kidney International · doi:10.1038/ki.1997.10 · Cited by 59
Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis.
Watanabe, M., McCormick, K. L., Völker, K., Ortaldo, J. R., Wigginton, J. M., Brunda, M. J., Wiltrout, R. H., & Fogler, W. E. (1997) · Europe PMC (PubMed Central) · Cited by 58
Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor α and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130
Neddermann, P., Graziani, R., Ciliberto, G., & Paonessa, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30986 · Cited by 58
Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice
Rothe, H. M., Burkart, V., Faust, A., et al. (1996) · Diabetologia · doi:10.1007/bf00400422 · Cited by 58
The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon
Ozmen, L., Aguet, M., Trinchieri, G., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.8147-8150.1995 · Cited by 58
Self-citation
IL-12 expression in AIDS-related lymphoma B cell lines
Benjamin, D., Sharma, V., Kubin, M. Z., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1626 · Cited by 57
High doses of interleukin‐12 inhibit the development of joint disease in DBA/1 mice immunized with type II collagen in complete Freund's adjuvant
Hess, H., Gately, M. K., Rüde, E., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260129 · Cited by 56
Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection
Saunders, B. M., Zhan, Y., & Cheers, C. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.4011-4015.1995 · Cited by 56
IL-12 directly enhances in vitro murine erythropoiesis in combination with IL-4 and stem cell factor.
Dybedal, I., Larsen, S., & Jacobsen, S. E. W. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.4950 · Cited by 55
IL-12 Inhibits Apoptosis Induced in a Human Th1 Clone by gp120/CD4 Cross-Linking and CD3/TCR Activation or by IL-2 Deprivation
Radrizzani, M., Accornero, P., Amidei, A., et al. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.1003 · Cited by 55
Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection
Wagner, R. D., Steinberg, H. N., Brown, J. F., et al. (1994) · Microbial Pathogenesis · doi:10.1006/mpat.1994.1064 · Cited by 55
Interleukin‐12 activates human γδ T cells: synergistic effect of tumor necrosis factor‐α
Ueta, C., KAWASUMI, H., Fujiwara, H., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830261237 · Cited by 54
Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation
Naume, B., Gately, M. K., Desai, B. B., et al. (1993) · Cytokine · doi:10.1016/1043-4666(93)90022-w · Cited by 54
Local TH1 and TH2 responses to parasitic infection in the intestine: regulation by IFN-gamma and IL-4
Urban, J. F., Fayer, R., Sullivan, C. A., et al. (1996) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(96)05708-x · Cited by 53
Administration of Recombinant Interleukin-12 to Mice Suppresses Hematopoiesis in the Bone Marrow but Enhances Hematopoiesis in the Spleen
Tare, N. S., Bowen, S., Warrier, R. R., et al. (1995) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1995.15.377 · Cited by 53
Exacerbated viral hepatitis in IFN-γ receptor-deficient mice is not suppressed by IL-12
Schijns, V. E. C. J., Wierda, C. M. H., van Hoeij, M. J. W., & Horzinek, M. C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.2.815 · Cited by 53
IL-12 activates IFN-gamma production through the preferential activation of CD30+ T cells.
Alzona, M. T., Jäck, H., Fisher, R. I., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.1.9 · Cited by 52
Type 1 and Type 2 Cytokines in HIV Infection – A Possible Role in Apoptosis and Disease Progression
Clerici, M., Fusi, M. L., Ruzzante, S., Piconi, S., Biasin, M., Arienti, D., Trabattoni, D., & Villa, M. L. (1997) · Annals of Medicine · doi:10.3109/07853899708999334 · Cited by 52
Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation
Valiante, N. M., Rengaraju, M., & Trinchieri, G. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90322-g · Cited by 51
Self-citation
Systemic Production of Interferon-Gamma Inducing Factor (IGIF) Versus Local IFN-γ Expression Involved in the Development of Th1 Insulitis in NOD Mice
Rothe, H., Hibino, T., Itoh, Y., et al. (1997) · Journal of Autoimmunity · doi:10.1006/jaut.1997.0135 · Cited by 51
Astrocytes and Microglia Produce Interleukin‐12 p40a
Constantinescu, C. S., Frei, K., Wysocka, M., Trinchieri, G., Malipiero, U., Rostami, A. M., & FONTANA, A. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb52684.x · Cited by 51
Self-citation
Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture.
Ploemacher, R. E., van Soest, P. L., Voorwinden, H. L., et al. (1993) · PubMed · Cited by 51
2 Cytokine receptors and signal transduction
Ihle, J. N., Witthuhn, B. A., Tang, B., Yi, T., & Quelle, F. W. (1994) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(05)80005-8 · Cited by 51
Interleukin 12 mRNA Expression in Islets Correlates with β-Cell Destruction in NOD Mice
Rabinovitch, A., Suarez-Pinzon, W. L., & Sorensen, O. (1996) · Journal of Autoimmunity · doi:10.1006/jaut.1996.0084 · Cited by 50
Normal B cells fail to secrete interleukin‐12
Guéry, J., Ria, F., Galbiati, F., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270707 · Cited by 50
IMMUNOMODULATION BYQUILLAJA SAPONARIAADJUVANT FORMULATIONS: IN VIVO STIMULATION OF INTERLEUKIN 12 AND ITS EFFECTS ON THE ANTIBODY RESPONSE
Villacrés-Eriksson, M., Behboudi, S., Morgan, A. J., et al. (1997) · Cytokine · doi:10.1006/cyto.1996.0139 · Cited by 50
Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients
Drulovic, J. S., Mostarica‐Stojković, M., Lević, Z., et al. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)05320-8 · Cited by 50
Interleukin-12 Stimulates B Cell Growth by Inducing IFN-γ
Li, L., Young, D., Wolf, S. F., et al. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0059 · Cited by 50
Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor.
Ploemacher, R., Pl, V. S., Boudewijn, A., et al. (1993) · PubMed · Cited by 50
Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection
Harrison, T. S., & Levitz, S. M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.11.4492 · Cited by 49
IFN-gamma-independent production of IL-12 during murine endotoxemia
Heinzel, F. P., Rerko, R. M., Ahmed, F., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4521 · Cited by 49

Research works printed but not linked: 10

Nadeau, 1995, Pharmacokinetics and pharmacodynamics of recombinant human IL-12 in male rhesus monkeys, J. Pharmacol. Exp. Therapeut., 274, 78
Sarmiento, 1994, Biologic effects of recombinant human interleukin-12 in squirrel monkeys, Sciureus saimiri). Lab. Invest., 71, 862
Wolf, 1992, Cell sources of natural killer cell stimulatory factor (NKSF/IL-12) transcripts and subunit expression, FASEB J., 6, A1335
Moller, D.R. Wysocka, M. Greenlee, B.M. Ma, X. Wahl, L. Flockhart, D.A. Trinchieri, G. Karp, C.L., (1997) Inhibition of interleukin 12 production by thalidomide. Submitted for publication · DOI
Wang, 1997, A critical role of interferon consensus sequence binding protein (ICSBP) in the activation of IL-12 p40 gene promoter, J. Interf. Cykokine Res., 17, 576
Not In, 1994, Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with. Toxoplasma gondii, J. Immunol., 153, 2533, 10.4049/jimmunol.153.6.2533 · DOI
Afonso, 1994, The adjuvant effect of interleukin-12 in a vaccine against, Leishmania major. Science, 263, 235
Kripte, 1990, Photoimmunology, Photochem. Photobiol., 52, 919
Waldburger, 1996, Am. J. Pathol., 148, 375
Constantinescu, 1997, Interleukin-12 is involved in spontaneous and superantigen-induced relapses in experimental allergic encephalomyelitis, Neurology, 48, 2070

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Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398
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Jouanguy, E., Döffinger, R., Dupuis, S., Pallier, A., Altare, F., & Casanova, J.-L. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80055-7 · Cited by 331
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Melchert, M., & List, A. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.022 · Cited by 246
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Authors: Trinchieri, G.
Affiliations: The Wistar Institute (US)
Corresponding author: Trinchieri, Giorgio
ORCID: Trinchieri, Giorgio
Venue: Advances in Immunology
Publisher: Elsevier
Published: 1998
Volume: 70
Pages: 83-243
ISSN: 0065-2776 (ISSN-L)
DOI: 10.1016/s0065-2776(08)60387-9
OpenAlex: W1598996496
Cited by: 760
References: 748
Citations by year: 2025: 6 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 16 · 2013: 23 · 2012: 18
FWCI: 102.24
Type: book chapter
Language: en
Open access: closed
Locations: Advances in immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca032898-13)
National Cancer Institute (CA 32898, CA-20833, CA-10815, P30CA010815)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: IL-12, inflammatory cytokines, immunomodulation, interferon-gamma, macrophage activation, innate immunity, adaptive immunity, infection, antitumor immunity, autoimmunity, allergy, cytokine adjuvants, immunotherapy
MeSH terms: Animals, Communicable Diseases, Gene Expression Regulation, Graft Rejection, Humans, Hypersensitivity, Immunity, Inflammation, Autoimmunity, Receptors, Interleukin, Interleukin-12, Receptors, Interleukin-12

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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

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