The DOI matches its Crossref record; 355 of the 355 references it cites were found in a registry or an index.
Insulin-Like Growth Factor Signaling in Fish
Abstract
The insulin-like growth factor (IGF) system plays a central role in the neuroendocrine regulation of growth in all vertebrates. Evidence from studies in a variety of vertebrate species suggest that this growth factor complex, composed of ligands, receptors, and high-affinity binding proteins, evolved early during vertebrate evolution. Among nonmammalian vertebrates, IGF signaling has been studied most extensively in fish, particularly teleosts of commercial importance. The unique life history characteristics associated with their primarily aquatic existence has fortuitously led to the identification of novel functions of the IGF system that are not evident from studies in mammals and other tetrapod vertebrates. Furthermore, the emergence of the zebrafish as a preferred model for development genetics has spawned progress in determining the requirements for IGF signaling during vertebrate embryonic development. This review is intended as a summary of our understanding of IGF signaling, as revealed through research into the expression, function, and evolution of IGF ligands, receptors, and binding proteins in fish.
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In the citing paper
“Igf-1 (Insulin-like growth factor 1) is structurally homologous to Insulin and although it can bind the Insulin receptor, its affinity is highest for the Igf-1 receptor (Igf1r) (Wood et al., 2005).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Wood et al., 2005
In the citing paper
“Furthermore, Igf binding proteins stabilize bound Igfs and modulate their activity (Wood et al., 2005).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Wood et al., 2005
In the citing paper
“Igf binding protein 3 (Igfbp3) is the most highly expressed Igfbp and binds most abundantly to Igf-1(Wood et al., 2005).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Wood et al., 2005
Citations
Cites
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Insulin-like growth factors and their binding proteins: biological actions
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Cellular Actions of the Insulin-Like Growth Factor Binding Proteins
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Cited by
Sorted by citations
Wan, J., Zhao, X.-F., Vojtek, A., & Goldman, D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.048 · Cited by 143
“Igf binding protein 3 (Igfbp3) is the most highly expressed Igfbp and binds most abundantly to Igf-1(Wood et al., 2005).”
BackgroundInfluentialDeep proteome analysis identifies age-related processes in C. elegans
Narayan, V., Ly, T., Pourkarimi, E., Murillo, A. B., Gartner, A., Lamond, A. I., & Kenyon, C. (2016) · Cell Systems · doi:10.1016/j.cels.2016.06.011 · Cited by 127
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Self-citationGene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors
Schlueter, P. J., Royer, T., Farah, M. H., Laser, B., Chan, S. J., Steiner, D. F., Duan, C., Schlueter, P. J., Royer, T., Farah, M. H., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-3882fje · Cited by 71
Self-citationLife‐history strategies in salmonids: the role of physiology and its consequences
Birnie‐Gauvin, K., Bordeleau, X., Cooke, S. J., Davidsen, J. G., Eldøy, S. H., Eliason, E. J., Moore, A., & Aarestrup, K. (2021) · Biological Reviews · doi:10.1111/brv.12753 · Cited by 68
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Metadata
- Authors
- Wood, A. W., Duan, C., & Bern, H. A.
- Affiliations
- University of Michigan (US)
- University of California, Berkeley (US)
- ORCID
- Duan, Cunming
- Venue
- International Review of Cytology
- Publisher
- Elsevier
- Published
- 2005
- Volume
- 243
- Pages
- 215-285
- ISSN
- 0074-7696 (ISSN-L)
- OpenAlex
- W1563869447
- Cited by
- 657
- References
- 355
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 26 · 2023: 32 · 2022: 45 · 2021: 44 · 2020: 56 · 2019: 37 · 2018: 41 · 2017: 41 · 2016: 35 · 2015: 39 · 2014: 28 · 2013: 24 · 2012: 24
- FWCI
- 75.53
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of cytology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- insulin-like growth factor signaling, fish, teleosts, IGF receptors, IGF binding proteins, growth regulation, neuroendocrine regulation, vertebrate evolution, zebrafish, embryonic development, gene expression
- MeSH terms
- Animals, Fishes, Humans, Ligands, Somatomedins, Zebrafish, Signal Transduction, Receptors, Somatomedin, Insulin-Like Growth Factor Binding Proteins, Evolution, Molecular
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