Transcranial sonography for the discrimination of idiopathic Parkinson's disease from the atypical parkinsonian syndromes
Abstract
We reviewed eight studies on transcranial sonography (TCS) as a tool for differentiating idiopathic Parkinson's disease (IPD) from atypical parkinsonian syndromes (APS) and included some first data on TCS findings in the subforms of PSP. Changes of specific structures on TCS like the substantia nigra (SN), lenticular nucleus (LN), and the third ventricle are discussed as well as how they can contribute to differentiate between IPD, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), Lewy body disease (LBD), and corticobasal degeneration (CBD). We finish with an algorithm that may be used to employ TCS as a diagnostic instrument delineating IPD from the APS and discerning among the APS themselves. As TCS is at present the most promising tool for this particular diagnostic problem, this algorithm might be a suitable hypothesis to study in future research.
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Transcranial sonography might be a helpful technique in the diagnosis of Parkinson's disease, Friedreich's ataxia, Huntington's disease, and restless leg syndrome and might be useful to differentiate between idiopathic Parkinson's disease and atypical parkinsonian syndromes.
“Transcranial sonography might be a helpful technique in the diagnosis of Parkinson’s disease, Friedreich’s ataxia, Huntington’s disease, and restless leg syndrome and might be useful to differentiate between idiopathic Parkinson’s disease and atypical parkinsonian syndromes.152”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [152]
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
- Authors
- Bouwmans, A. E. P., Vlaar, A. M. M., Srulijes, K., Mess, W. H., & Weber, W. E. J.
- Affiliations
- Maastricht University Medical Centre (NL)
- Sint Lucas Andreas Hospital (NL)
- German Center for Neurodegenerative Diseases (DE)
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2010
- Volume
- 90
- Pages
- 121-146
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W1554520125
- Cited by
- 40
- References
- 55
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 7.37
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- transcranial ultrasound, idiopathic Parkinson's disease, atypical parkinsonism, differential diagnosis, multiple system atrophy, progressive supranuclear palsy, Lewy body disease, corticobasal degeneration, substantia nigra, lentiform nucleus, third ventricle, diagnostic algorithm
- MeSH terms
- Brain, Diagnosis, Differential, Humans, Parkinson Disease, Predictive Value of Tests, Ultrasonography, Doppler, Transcranial, Parkinsonian Disorders
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