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[18] Quantification of β-sheet amyloid fibril structures with thioflavin T
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“Both compounds L1 and L2 contain a 2-phenylbenzothiazole fragment reminiscent of the fluorescent dye ThT used to detect the β-sheet structure of fibrillar Aβ aggregates.45,46”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [46]
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Cited by
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Makhaeva, G., Grishchenko, M. V., Rudakova, E., Kovaleva, N., Boltneva, N., Skornyakova, T. S., Khudina, O. G., Shchegolkov, E., Zhilina, E. F., Astakhova, T., et al. (2025) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2025.118397 · Cited by 4
Are amyloid-based materials conducive to tissue engineering?
Patel, K., & Maji, S. K. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.08.009 · Cited by 5
Kashiyama, R., Watanabe, H., Akasaka, T., Fujimoto, H., Murakami, M., Ooe, K., Toyoshima, A., Nakashima, K., & Ono, M. (2025) · Annals of Nuclear Medicine · doi:10.1007/s12149-025-02095-8 · Cited by 4
Metadata
- Authors
- LeVine, H.
- Corresponding author
- LeVine, Harry
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 1999
- Volume
- 309
- Pages
- 274-284
- ISSN
- 0076-6879 (ISSN-L)
- OpenAlex
- W1588296570
- Cited by
- 1,365
- References
- 25
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 56 · 2023: 42 · 2022: 51 · 2021: 54 · 2020: 60 · 2019: 78 · 2018: 86 · 2017: 69 · 2016: 61 · 2015: 67 · 2014: 78 · 2013: 58 · 2012: 66
- FWCI
- 28.63
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- thioflavin T, amyloid fibrils, beta-sheet, amyloid quantification, Congo red, amyloid staining, amyloid fibril formation, fluorescence spectroscopy, Congo red birefringence
- MeSH terms
- Fluorescence, Hydrogen-Ion Concentration, Protein Binding, Spectrum Analysis, Thiazoles, Amyloid beta-Peptides, Protein Structure, Secondary, Benzothiazoles
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