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Cited by 594Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsMemory Processes and Influences

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

The functional neuroanatomy of PTSD: a critical review

Liberzon, Israel, Sripada, Chandra Sekhar·2007·Progress in Brain Research
DOI 10.1016/s0079-6123(07)67011-3
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Abstract

Neuroimaging provides an opportunity to understand core processes that mediate the experience of emotions in healthy individuals as well as dysregulation of these processes in conditions such as posttraumatic stress disorder (PTSD). The first decade of neuroimaging research produced symptom provocation, cognitive activation, and functional connectivity studies that highlighted the role of the medial prefrontal cortex (mPFC), amygdala, sublenticular extended amygdala (SLEA), and hippocampus, in mediating symptom formation in PTSD. There is a growing realization that a number of other psychological processes are relevant to PTSD, and they are emerging as a new focus of neuroimaging research. These include fear conditioning, habituation, and extinction; cognitive-emotional interactions; and self-related and social emotional processing. Neuroimaging findings are reviewed that suggest that the mPFC is implicated in a number of these processes. It is proposed that the mPFC plays a role in the "contextualization" of stimuli, and dysregulation of contextualization processes might play a key role in the generation of PTSD symptoms.

Overview

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Crossref · 10.1016/s0079-6123(07)67011-3

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71 of 71 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Liberzon, I., & Sripada, C. S.
Affiliations
University of Michigan (US)
Corresponding author
Liberzon, Israel
ORCID
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2007
Volume
167
Pages
151-169
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(07)67011-3
OpenAlex
W1564331199
Cited by
594
References
71
Citations by year
2026: 11 · 2025: 17 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 33 · 2020: 45 · 2019: 24 · 2018: 42 · 2017: 37 · 2016: 46 · 2015: 37 · 2014: 46 · 2013: 42 · 2012: 43
FWCI
91.41
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
post-traumatic stress disorder, functional neuroanatomy, medial prefrontal cortex, amygdala, hippocampus, fear conditioning, habituation, extinction, cognitive-emotional interaction, social-emotional processing, contextualization, emotional dysregulation
MeSH terms
Animals, Cognition, Humans, Magnetic Resonance Imaging, Stress Disorders, Post-Traumatic, Prefrontal Cortex

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