Tamoxifen for flutamide/finasteride-induced gynecomastia.
Open accessAbstract
OBJECTIVES: Current therapies for advanced prostate carcinoma lead to a marked decrease in serum testosterone levels, which renders patients impotent. In preliminary studies, combination therapy with flutamide and finasteride has been used as an alternative therapy for the treatment of prostate carcinoma because potency can be preserved. Both of these agents can cause gynecomastia and breast/nipple tenderness. METHODS: Six men being treated for advanced prostate carcinoma with flutamide/finasteride combination therapy developed painful gynecomastia, which was treated with tamoxifen 10 to 30 mg/day for 1 month. Clinical follow-up included breast measurements and determination of prostate-specific antigen (PSA), testosterone, and estradiol levels. RESULTS: While on this combination therapy for prostate carcinoma, 4 of 6 patients experienced a decrease in PSA level to less than 0.5 ng/mL. All patients remained potent. Serum testosterone increased in each patient who had a baseline level drawn. Estradiol levels were noted to be elevated in 4 of 6 patients at the time of evaluation for gynecomastia. After treatment with tamoxifen, circulating estradiol levels increased in 3 patients from 1.3 to 2.2 times the baseline level. Five patients experienced complete resolution of breast and nipple pain on tamoxifen 10 mg/day within the first month. The other patient had to be treated with 30 mg/day for 1 additional month, which subsequently resulted in pain resolution. CONCLUSIONS: These preliminary results suggest that low-dose tamoxifen is useful in treating painful gynecomastia for those patients on flutamide/finasteride combination therapy for advanced prostate carcinoma.
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Suppression of androgens in men is associated with breast growth.
“It is of interest that suppression of androgens in men is associated with breast growth (198).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [198]
Cites
The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Gormley, G. J., Stoner, E., Bruskewitz, R. C., Imperato‐McGinley, J., Walsh, P. C., McConnell, J. D., Andriole, G. L., Geller, J., Bracken, B. R., Tenover, J. L., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210223271701 · Cited by 1,104 · see citing works
Desforges, J. F., & Braunstein, G. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302183280708 · Cited by 395 · see citing works
NERI, R. O., FLORANCE, K., Koziol, P., & CLEAVE, S. V. (1972) · Endocrinology · doi:10.1210/endo-91-2-427 · Cited by 326 · see citing works
Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy
Sogani, P. C., Vagaiwala, M. R., & Whitmore, W. F. (1984) · Cancer · doi:10.1002/1097-0142(1984)54:4 · Cited by 160 · see citing works
Treatment of gynecomastia with tamoxifen: A double-blind crossover study
Parker, L. N., Gray, D. R., Lai, M. K., & Levin, E. R. (1986) · Metabolism · doi:10.1016/0026-0495(86)90237-4 · Cited by 115 · see citing works
Combined finasteride and flutamide therapy in men with advanced prostate cancer
Ornstein, D. K., Rao, G. S., Johnson, B., Charlton, E. T., & Andriole, G. L. (1996) · Urology · doi:10.1016/s0090-4295(96)00315-9 · Cited by 79 · see citing works
HELLMAN, L., Bradlow, H. L., Freed, S. Z., LEVIN, J., Rosenfeld, R. S., Whitmore, W. F., & Zumoff, B. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-6-1224 · Cited by 76 · see citing works
Tamoxifen Therapy for Painful Idiopathic Gynecomastia
McDermott, M. T., Hofeldt, F. D., & Kidd, G. S. (1990) · Southern Medical Journal · doi:10.1097/00007611-199011000-00013 · Cited by 72 · see citing works
Experience with Flutamide in Previously Untreated Patients With Advanced Prostatic Cancer
Sogani, P. C., & Whitmore, W. F. (1979) · The Journal of Urology · doi:10.1016/s0022-5347(17)56539-8 · Cited by 71 · see citing works
New Methods of Endocrine Management of Prostatic Cancer
Smith, J. A. J. (1987) · The Journal of Urology · doi:10.1016/s0022-5347(17)43855-9 · Cited by 67 · see citing works
Prostatic Cancer and Sch-13521: II. Histological Alterations and the Pituitary Gonadal Axis
Prout, G. R., Irwin, R. J., Kliman, B., Daly, J. J., MacLaughlin, R. A., & Griffin, P. P. (1975) · The Journal of Urology · doi:10.1016/s0022-5347(17)59593-2 · Cited by 62 · see citing works
Estradiol Formation from Testosterone by Continuously Cultured Human Breast Cancer Cells*
MacIndoe, J. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-2-272 · Cited by 55 · see citing works
Glass, A. R. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30070-7 · Cited by 50 · see citing works
Idiopathic gynecomastia treated with tamoxifen: a preliminary report.
Alagaratnam, T. T. (1987) · PubMed · Cited by 46 · see citing works
Flutamide in the Treatment of Metastatic Carcinoma of the Prostate
NARAYANA, A. S., Loening, S. A., & Culp, D. A. (1981) · British Journal of Urology · doi:10.1111/j.1464-410x.1981.tb03157.x · Cited by 41 · see citing works
Radiotherapeutic prophylaxis of estrogen-induced gynecomastia: A study of late sequela
Fass, D. E., Steinfeld, A., Brown, J. S., & Tessler, A. N. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90359-7 · Cited by 38 · see citing works
Sequential Androgen Blockade: A Biological Study in the Inhibition of Prostatic Growth
Fleshner, N. E., & Trachtenberg, J. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)37086-6 · Cited by 29 · see citing works
Painful gynaecomastia treated with tamoxifen.
Jefferys, D. B. (1979) · BMJ · doi:10.1136/bmj.1.6171.1119-a · Cited by 28 · see citing works
A study of the effects of radiation on prevention of gynaecomastia due to oestrogen therapy.
Waterfall, N., & Glaser, M. G. (1979) · PubMed · Cited by 25 · see citing works
Narayan, P. A., Trachtenberg, J., Lepor, H., Debruyne, E. J., Tewari, A. K., Stone, N. N., Das, S. P., Jimenez-Cruz, J. E., Shearer, R. J., Klimberg, I. W., et al. (1996) · Urology · doi:10.1016/s0090-4295(99)80484-1 · Cited by 24 · see citing works
Fleshner, N. E., & Trachtenberg, J. (1993) · European Urology · doi:10.1159/000474400 · Cited by 24 · see citing works
Artificial pneumothorax can be used to prevent lung toxicity in chest wall radiotherapy
Christie, D., Spry, N. A., Lamb, D. S., & Sadler, H. B. (1993) · Clinical Oncology · doi:10.1016/s0936-6555(05)80242-0 · Cited by 16 · see citing works
Painful gynecomastia treated with tamoxifen
Boo-Chai, K. (1980) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198002000-00067 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Braunstein, G. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmcp070677 · Cited by 426 · see citing works
Anabolic steroid–induced hypogonadism: diagnosis and treatment
Rahnema, C. D., Lipshultz, L. I., Crosnoe-Shipley, L., Kovac, J. R., & Kim, E. D. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.002 · Cited by 255 · see citing works
Zhou, J., Ng, S., Adesanya-Famuiya, O., Anderson, K., & Bondy, C. A. (2000) · The FASEB Journal · doi:10.1096/fj.99-0863com · Cited by 193 · see citing works
A physiologic role for testosterone in limiting estrogenic stimulation of the breast
Dimitrakakis, C., Zhou, J., Wang, J., Bélanger, A., Labrie, F., Cheng, C. M., Powell, D., & Bondy, C. A. (2003) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000055522.67459.89 · Cited by 175 · see citing works
Plourde, P. V., Reiter, E. O., Jou, H.-C., Desrochers, P. E., Rubin, S. D., Bercu, B. B., Diamond, F. B., Backeljauw, P. F., & Study, M. O. T. A. G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0082 · Cited by 128 · see citing works
Widmark, A., Fosså, S. D., Lundmo, P. I., Damber, J. ‐., Vaage, S., Damber, L., Wiklund, F. E., & Klepp, O. (2003) · Urology · doi:10.1016/s0090-4295(02)02107-6 · Cited by 101 · see citing works
Tamoxifen in men: a review of adverse events
Wibowo, E., Pollock, P. A., Hollis, N., & Wassersug, R. J. (2016) · Andrology · doi:10.1111/andr.12197 · Cited by 97 · see citing works
Androgens and mammary growth and neoplasia
Dimitrakakis, C., Zhou, J., & Bondy, C. A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02979-5 · Cited by 94 · see citing works
Villani, D., & Meghi, P. (2014) · Springer eBooks · doi:10.1007/978-3-319-06118-4_6 · Cited by 83 · see citing works
Gynecomastia in patients with prostate cancer: a review of treatment options
McLeod, D. G., & Iversen, P. (2000) · Urology · doi:10.1016/s0090-4295(00)00823-2 · Cited by 82 · see citing works
Wirth, M. P., Tyrrell, C., Wallace, M., Delaere, K. P. J., Sánchez‐Chapado, M., Ramon, J., Jw, H., Pina, F., Heynes, C. F., Borchers, T. M., et al. (2001) · Urology · doi:10.1016/s0090-4295(01)01213-4 · Cited by 82 · see citing works
Management of gynaecomastia: an update
Gikas, P. D., & Mokbel, K. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01095.x · Cited by 79 · see citing works
Saltzstein, D., Sieber, P., Morris, T., & Gallo, J. (2005) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500782 · Cited by 78 · see citing works
Antiandrogen monotherapy: a new form of treatment for patients with prostate cancer
Kolvenbag, G. J. C. M., Iversen, P., & Newling, D. W. W. (2001) · Urology · doi:10.1016/s0090-4295(01)01237-7 · Cited by 66 · see citing works
Eckman, A., & Dobs, A. S. (2008) · Expert Opinion on Drug Safety · doi:10.1517/14740330802442382 · Cited by 64 · see citing works
Dicker, A. P. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)00958-6 · Cited by 56 · see citing works
INCIDENCE AND MANAGEMENT OF GYNECOMASTIA IN MEN TREATED FOR PROSTATE CANCER
Dobs, A. S., & Darkes, M. J. M. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176461.75794.f8 · Cited by 54 · see citing works
Flavonoids can block PSA production by breast and prostate cancer cell lines
Zand, R. S. R., Jenkins, D. J. A., Brown, T. J., & Diamandis, E. P. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00698-2 · Cited by 51 · see citing works
Management of gynaecomastia in patients with prostate cancer: a systematic review
Lorenzo, G. D., Riccardo Autorino, B., Perdonà, S., & Placido, S. D. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70464-2 · Cited by 50 · see citing works
Boccardo, F., Barichello, M., Battaglia, M., CARMIGNANI, G., Comeri, G., Ferraris, V., Lilliu, S., Montefiore, F., Portoghese, F., Cortellini, P., et al. (2002) · European Urology · doi:10.1016/s0302-2838(02)00435-9 · Cited by 48 · see citing works
Chemoprevention of Prostate Cancer: Current Status and Future Directions
Lieberman, R. (2002) · Cancer and Metastasis Reviews · doi:10.1023/a:1021267128567 · Cited by 47 · see citing works
Androgen receptors as a prognostic and predictive factor in breast cancer.
Agrawal, A. K., Jeleń, M., Grzebieniak, Z., Żukrowski, P., Rudnicki, J., & Nienartowicz, E. (2008) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-008-0039-y · Cited by 45 · see citing works
Li, X., Strauss, L., Mäkelä, S., Streng, T., Huhtaniemi, I. T., Santti, R., & POUTANEN, M. H. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63191-4 · Cited by 39 · see citing works
Kunath, F., Keck, B., Antes, G., Wullich, B., & Meerpohl, J. J. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-96 · Cited by 37 · see citing works
Complications of androgen deprivation therapy in men with prostate cancer
Chen, A. C., & Petrylak, D. P. (2004) · Current Oncology Reports · doi:10.1007/s11912-004-0051-0 · Cited by 34 · see citing works
Lieberman, R. (2001) · Urology · doi:10.1016/s0090-4295(01)01247-x · Cited by 30 · see citing works
Current concepts in gynaecomastia
Devalia, H., & Layer, G. T. (2009) · The Surgeon · doi:10.1016/s1479-666x(09)80026-7 · Cited by 29 · see citing works
Side‐effects of treatments for locally advanced prostate cancer
O’Connor, K. M., & Fitzpatrick, J. M. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.05865.x · Cited by 26 · see citing works
Prezioso, D., Piccirillo, G., Galasso, R., Altieri, V. M., Mirone, V. G., & Lotti, T. (2004) · Tumori Journal · doi:10.1177/030089160409000409 · Cited by 26 · see citing works
Endocrine approaches in the therapy of prostate carcinoma
d’Ancona, F. C. H., & Debruyne, F. M. J. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi004 · Cited by 25 · see citing works
Treatment of bicalutamide-induced breast events
SIEBER, P. R. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.12.1773 · Cited by 25 · see citing works
Complications of androgen-deprivation therapy in men with prostate cancer
Chen, A. C., & Petrylak, D. P. (2005) · Current Urology Reports · doi:10.1007/s11934-005-0009-2 · Cited by 24 · see citing works
Hormone therapy of prostate cancer: is there a role for antiandrogen monotherapy?
Boccardo, F. (2000) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00051-2 · Cited by 24 · see citing works
Immunohistochemical Localization of Prostate-Specific Antigen in Ductal Epithelium of Male Breast
Gatalica, Z., Norris, B. A., & Kovatich, A. J. (2000) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200006000-00011 · Cited by 19 · see citing works
Wade, M. S., & Sinclair, R. D. (2000) · Australasian Journal of Dermatology · doi:10.1046/j.1440-0960.2000.00392.x · Cited by 17 · see citing works
Angwafor, F., & Anderson, M. L. (2008) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-5-12 · Cited by 14 · see citing works
Nayebi, A. M., & Rezazadeh, H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.09.009 · Cited by 13 · see citing works
(2000) · Climacteric · doi:10.1080/13697130008500119 · Cited by 12 · see citing works
Karuppusamy, N., Srinithi, S., Chen, S., Veerakumar, P., Lin, K.-Y., & Meenakshi, S. (2023) · New Journal of Chemistry · doi:10.1039/d3nj02800c · Cited by 11 · see citing works
THE ROLE OF TAMOXIFEN IN REDUCING BICALUTAMIDE‐INDUCED GYNAECOMASTIA AND BREAST PAIN
Nuttall, M. C., Harris, J. P., & Dawkins, G. P. C. (2007) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06552.x · Cited by 10 · see citing works
The drugs that mostly frequently induce gynecomastia: A national case – noncase study
Batteux, B., Llopis, B., Muller, C., Khouri, C., Moragny, J., Liabeuf, S., Masmoudi, K., & Gras, V. (2019) · Therapies · doi:10.1016/j.therap.2019.06.001 · Cited by 10 · see citing works
Enzo Devoto, C., Marcia Madariaga, A., Ximena Lioi, C., & Mardones, N. (2007) · Revista médica de Chile · doi:10.4067/s0034-98872007001200009 · Cited by 9 · see citing works
Sun, Y., Xu, T., Zhu, S., & Xu, H. (2023) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2023.2267978 · Cited by 8 · see citing works
[Gynecomastia--pathogenesis, diagnosis and treatment].
Czajka-Oraniec, I., & Zgliczyński, W. (2005) · PubMed · Cited by 6 · see citing works
Pearlman, G., & Carlson, H. E. (2006) · The Endocrinologist · doi:10.1097/01.ten.0000205637.20746.10 · Cited by 6 · see citing works
Lee, S. G., Park, P. J., Lee, S. R., Koo, B. H., Byun, G. Y., Kim, S., Kang, H. J., Kim, S., Oh, B. S., & Lee, Y. H. (2019) · American Journal of Men s Health · doi:10.1177/1557988319871423 · Cited by 5 · see citing works
Menon, S., & Kuhn, J. M. (2009) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(09)51194-8 · Cited by 3 · see citing works
Kishan, A. U., Chen, M., Loffredo, M. J., Kim, D., Beard, C. J., Hurwitz, M., Martin, N. E., Orio, P. F., Kantoff, P. W., D'Amico, A. V., et al. (2011) · Practical Radiation Oncology · doi:10.1016/j.prro.2011.08.002 · Cited by 1 · see citing works
Prostatakarzinom beim geriatrischen Patienten
Wiedemann, A. (2020) · Springer eBooks · doi:10.1007/978-3-662-61494-5_11 · Cited by 1 · see citing works
Santen, R. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00140-4 · Cited by 1 · see citing works
Leibovitch, I., Gillatt, D. A., Hopwood, P., Iversen, P., Mansel, R. E., McLeod, D. G. R., Vela‐Navarrete, R., Richaud, P. M., See, W., Tyrrell, C., et al. (2003) · Clinical Drug Investigation · doi:10.2165/00044011-200323030-00006 · Cited by 1 · see citing works
Kuhn, J. (2006) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(06)70398-1
Kuhn, J.-M. (2006) · EMC - Traité de médecine AKOS · doi:10.1016/s1634-6939(06)41284-9
Androgendeprivative Therapie des Prostatakarzinoms aus geriatrischer Sicht
Wiedemann, A., Becher, K. F., Manseck, A., Stein, J. R., Fröhner, M., Fiebig, C., Piotrowski, A., Kirschner-Hermanns, R. K. M., Bannowsky, A., Wirz, S., et al. (2025) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-025-02454-0
Sears, C. S., Watson, R., Brown, E., Abbas, B., Schellhammer, P. E., & Wassersug, R. J. (2026) · British Journal of Urology · doi:10.1111/bju.70374
Hormonal Manipulation of Prostate Cancer
Kamradt, J. M., & Pienta, K. J. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-223-4_15
- Authors
- Staiman, V. R., & Lowe, F. C.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Venue
- Urology
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 50
- Issue
- 6
- Pages
- 929-933
- ISSN
- 0090-4295 (ISSN-L)
- OpenAlex
- W2078896882
- Cited by
- 58
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2020: 1 · 2019: 2 · 2016: 1 · 2014: 2 · 2012: 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Urology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Male Breast Health Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- tamoxifen, gynecomastia, flutamide, finasteride, testosterone, estradiol, prostate-specific antigen, erectile function, breast pain
- MeSH terms
- Aged, Androgen Antagonists, Drug Evaluation, Drug Therapy, Combination, Enzyme Inhibitors, Estradiol, Estrogen Antagonists, Flutamide, Gynecomastia, Humans, Male, Middle Aged, Prostatic Neoplasms, Tamoxifen, Testosterone, Time Factors, Finasteride
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