Acetylcholine Release in Ventral Tegmental Area by Hypothalamic Self-Stimulation, Eating, and Drinking
Abstract
Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self-stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self-stimulation and ingestive behavior.
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Food or sugar intake can increase acetylcholine release in the VTA.
“Food or sugar intake can increase acetylcholine release in the VTA (Hajnal et al. 1998;Rada et al. 2000)”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Rada et al. 2000
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Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Self-citationWise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881 · see citing works
Jerlhag, E., Egecioglu, E., Dickson, S. L., Douhan, A., Svensson, L., & Engel, J. A. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00041.x · Cited by 431 · see citing works
Mechanisms of Nicotine Addiction
Picciotto, M. R., & Kenny, P. J. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039610 · Cited by 157 · see citing works
You, Z.-B., Wang, B., Zitzman, D., & Wise, R. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0694-08.2008 · Cited by 71 · see citing works
Modulation of cellular activity and synaptic transmission in the ventral tegmental area
Mathon, D. S., Kamal, A., Smidt, M. P., & Ramakers, G. M. J. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.097 · Cited by 41 · see citing works
- Authors
- Rada, P. V., Mark, G. P., Yeomans, J. J., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Oregon Health & Science University (US)
- Corresponding author
- Hoebel, Bartley G
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 65
- Issue
- 3
- Pages
- 375-379
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2010578990
- Cited by
- 106
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 9
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acetylcholine, ventral tegmental area, self-stimulation, hypothalamus, dietary habits, drinking behavior, ingestive behavior, atropine, muscarinic receptors, dietary intake
- MeSH terms
- Animals, Atropine, Drinking, Eating, Hypothalamus, Male, Self Stimulation, Rats, Sprague-Dawley, Microdialysis, Ventral Tegmental Area, Rats
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