PRECLINICAL STUDY: Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

Jerlhag, Elisabet; Egecioglu, Emil; Dickson, Suzanne L.; Douhan, Annika; Svensson, Lennart; Engel, Jörgen A.

doi:10.1111/j.1369-1600.2006.00041.x

Cited by 431Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

PRECLINICAL STUDY: Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

Jerlhag, Elisabet, Egecioglu, Emil, Dickson, Suzanne L., Douhan, Annika, Svensson, Lennart, Engel, Jörgen A.·2007·Addiction Biology

DOI 10.1111/j.1369-1600.2006.00041.x

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Abstract

Ghrelin stimulates appetite, increases food intake and causes adiposity by mechanisms that include direct actions on the brain. Previously, we showed that intracerebroventricular administration of ghrelin has stimulatory and dopamine‐enhancing properties. These effects of ghrelin are mediated via central nicotine receptors, suggesting that ghrelin can activate the acetylcholine–dopamine reward link. This reward link consists of cholinergic input from the laterodorsal tegmental area (LDTg) to the mesolimbic dopamine system that originates in the ventral tegmental area (VTA) and projects to the nucleus accumbens. Given that growth hormone secretagogue receptors (GHSR‐1A) are expressed in the VTA and LDTg, brain areas involved in reward, the present series of experiments were undertaken to examine the hypothesis that these regions may mediate the stimulatory and dopamine‐enhancing effects of ghrelin, by means of locomotor activity and in vivo microdialysis in freely moving mice. We found that local administration of ghrelin into the VTA (1 µg in 1 µl) induced an increase in locomotor activity and in the extracellular concentration of accumbal dopamine. In addition, local administration of ghrelin into the LDTg (1 µg in 1 µl) caused a locomotor stimulation and an increase in the extracellular levels of accumbal dopamine. Taken together, this indicates that ghrelin might, via activation of GHSR‐1A in the VTA and LDTg, stimulate the acetylcholine–dopamine reward link, implicating that ghrelin is a part of the neurochemical overlap between the reward systems and those that regulate energy balance.

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VTA and/or NAc neurons express receptors for GLP-1, ghrelin, leptin, insulin, orexin, and melanocortin.
“neurons in the VTA and/or NAc express GLP-1 (24,25), ghrelin (26,27), leptin (28,29), insulin (30), orexin (31) and melanocortin receptors (32).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [27]
VTA and/or NAc neurons express receptors for GLP-1, ghrelin, leptin, insulin, orexin, and melanocortin.
“Moreover, neurons in VTA and/or nucleus accumbens (NAc) express glucagon-like peptide-1 (11,12), ghrelin (13,14), leptin (15,16), insulin (17), orexin (18), and melanocortin receptors (19).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [14]
Ghrelin action directly within the VTA activates dopamine neurons, increases accumbens dopamine turnover, and increases food intake.
“In contrast, ghrelin action directly within the VTA appears to activate dopamine neurons, increase accumbens dopamine turnover, and increase food intake”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [88]

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Authors: Jerlhag, E., Egecioglu, E., Dickson, S. L., Douhan, A., Svensson, L., & Engel, J. A.
Affiliations: University of Gothenburg (SE)
Corresponding author: Engel, Jörgen A.
ORCID: Jerlhag, Elisabet
Dickson, Suzanne L.
Venue: Addiction Biology
Publisher: Wiley
Published: 2006-12-06
Volume: 12
Issue: 1
Pages: 6-16
ISSN: 1355-6215 (ISSN-L)
1369-1600
DOI: 10.1111/j.1369-1600.2006.00041.x
OpenAlex: W1915088265
Cited by: 431
References: 75
Citations by year: 2026: 9 · 2025: 13 · 2024: 19 · 2023: 14 · 2022: 25 · 2021: 20 · 2020: 25 · 2019: 17 · 2018: 22 · 2017: 24 · 2016: 16 · 2015: 27 · 2014: 24 · 2013: 25 · 2012: 34
FWCI: 6.64
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Addiction Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Vetenskapsrådet
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: ghrelin, growth hormone secretagogue receptor, ventral tegmental area, nucleus accumbens, dopamine, locomotor activity, mesolimbic dopamine system, energy balance, reward systems, intracerebroventricular administration
MeSH terms: Acetylcholine, Animals, Brain Mapping, Dopamine, Male, Mice, Inbred Strains, Motor Activity, Neural Pathways, Nucleus Accumbens, Reward, Tegmentum Mesencephali, Microdialysis, Ventral Tegmental Area, Peptide Hormones, Receptors, G-Protein-Coupled, Extracellular Fluid, Mice, Ghrelin, Receptors, Ghrelin

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PRECLINICAL STUDY: Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

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